Clinical Research Directory

Inclusion Criteria: * Healthy volunteers (males and females) aged 18 to 60 years; * Written informed consent to participate in the clinical trial; * Ability to comply with protocol requirements (i.e., to complete the Self-Observation Diary and attend follow-up visits); * Completed poliomyelitis vaccination in accordance with the current National Immunization Schedule; * For women of childbearing potential: negative pregnancy test and agreement to use adequate contraception methods. Hormonal contraceptives, if used, must be discontinued at least 2 months before the start of the study. All women of childbearing potential must have a negative pregnancy test during the baseline data collection period. Throughout the study, women must use contraception methods with a reliability of more than 90%, or be sterile or postmenopausal. Contraception methods with a typical-use reliability of more than 90% include cervical caps with spermicide, diaphragms with spermicide, condoms, and intrauterine devices. Exclusion Criteria: * Poliomyelitis revaccination less than 5 years before enrollment; * Serious post-vaccination reactions/complications associated with previous vaccination; * Allergic reactions to vaccine components or to any previous vaccination; * Receipt of any vaccine within one month before the study; * History of leukemia, malignant neoplasms, or positive test for HIV infection, hepatitis B or hepatitis C; * Receipt of immunoglobulin preparations or blood transfusion within the last 3 months before the study; * Long-term use (more than 14 days) of immunosuppressants or other immunomodulating drugs within 6 months before the study; * Any confirmed or suspected immunosuppressive or immunodeficiency condition; * Chronic diseases of the cardiovascular, bronchopulmonary, gastrointestinal systems, liver, kidneys, or blood in the acute or decompensated stage; * Progressive neurological disease, convulsive syndrome; * History of registration at a tuberculosis, substance abuse, neuropsychiatric, or other specialized dispensary; * Acute infectious disease less than 4 weeks before the study; * Alcohol consumption of more than 10 units per week, or history of alcoholism, drug addiction, or drug abuse; * Smoking more than 10 cigarettes per day; * Participation in any other clinical study within the last 3 months; * Pregnancy or breastfeeding; * Serious concomitant diseases or pathological conditions not listed above that, in the Investigator's opinion, could complicate the evaluation of study results, including abnormal blood and urine test values deviating from age-related or laboratory norms that are clinically significant in the Investigator's opinion; * Any disorder, including laboratory abnormalities, that in the Investigator's opinion exposes the volunteer to unacceptable risk if participating in the study or interferes with the interpretation of study data.