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Tramadol Versus Morphine for Postoperative Pain Relief Following Laparoscopic Abdominal Surgery
Sponsor: Centre Hospitalier Universitaire, Amiens
Summary
Tramadol is commonly used postoperatively due to its ease of administration, but it carries several risks, including interindividual variability, drug interactions, neuropsychiatric risks in elderly patients, and long-term dependence. Although its analgesic efficacy is comparable to that of strong opioids, its role in a multimodal analgesia strategy remains insufficiently studied. Research tailored to current clinical practices is needed to accurately assess its tolerance profile.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2025-12-22
Completion Date
2028-07
Last Updated
2026-11-03
Healthy Volunteers
No
Interventions
Anesthesia induction
Anesthesia induction with Propofol, Ketamine, Sufentanil, Lidocaine, and Dexamethasone
Anesthesia maintenance
Anesthesia maintenance with Sevoflurane, Sufentanil, and Lidocaine
Multimodal analgesia
Multimodal analgesia with Paracetamol, Ketoprofen, and Nefopam.
Morphine
Morphine titration 2mg/5min if actual weight \<50kg, 3mg/5min if actual weight≥50kg if NRS≥3/10 despite administration of paracetamol, ketoprofen and nefopam in recovery room. Oral intake on return to the surgical ward with morphine 10 mg every 4 hours if actual weight ≥50 kg, 5 mg every 4 hours if weight \<50 kg, if NRS ≥3/10 despite administration of paracetamol, ketoprofen, and nefopam.
Tramadol
Tramadol: 100 mg every 6 hours if actual weight ≥50 kg, 50 mg every 6 hours if weight \<50 kg, if NRS ≥3/10 despite administration of paracetamol, ketoprofen, and nefopam Oral intake on return to the surgical ward at the same doses
Locations (1)
CHU Amiens-Picardie
Amiens, France