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Autologous PRP Versus Triamcinolone Acetate in Patients With Oral Submucous Fibrosis
Sponsor: Allama Iqbal Medical College
Summary
Oral submucous fibrosis (OSF) is a chronic condition that causes stiffness of the oral tissues, reduced cheek flexibility, and difficulty opening the mouth. This randomized controlled clinical trial will compare the effects of intralesional autologous platelet-rich plasma (PRP) and triamcinolone acetate in patients with OSF. A total of 40 patients will be divided into two groups of 20. Group A will receive 1 ml of intralesional PRP, and Group B will receive 1 ml of intralesional triamcinolone acetate (40 mg/ml), once weekly for six weeks. Maximum interincisal distance and cheek flexibility will be measured before treatment, at six weeks, and at three months after treatment completion. The study will compare changes in these outcomes between the two groups to evaluate the effects of both treatments.
Official title: Comparison of Effects of Intralesional Injection of Autologous Platelet-Rich Plasma Vs Triamcinolone Acetate on Trismus/Maximum Interincisal Distance and Cheek Flexibility in Patients of Oral Submucous Fibrosis
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-11-01
Completion Date
2029-12-31
Last Updated
2026-11-03
Healthy Volunteers
No
Conditions
Interventions
Autologous Platelet-Rich Plasma
Freshly prepared autologous platelet-rich plasma (1 ml) administered via intralesional injection directly into fibrotic bands along the buccal mucosa and retromolar trigone area bilaterally using a 1 ml insulin syringe once a week for 6 consecutive weeks.
Triamcinolone Acetate
Triamcinolone acetate 1 ml (40 mg/ml) administered via intralesional injection directly into fibrotic bands along the buccal mucosa and retromolar trigone area bilaterally using a 1 ml insulin syringe once a week for 6 consecutive weeks.
Locations (1)
Jinnah Hospital, Lahore / Allama Iqbal Medical College
Lahore, Punjab Province, Pakistan