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Tundra lists 2 Auricular Vagus Nerve Stimulation clinical trials. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.
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NCT07904949
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction
Background: Arthroscopic anterior cruciate ligament reconstruction (ACLR) is a common orthopedic surgery. Postoperative pain, inflammatory response and opioid-related adverse events impair early recovery quality. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neuromodulation technique with potential analgesic and anti-inflammatory effects. Participants: A total of 144 eligible participants undergoing ACLR under spinal anesthesia combined with an adductor canal block will be enrolled. Methods: This prospective, randomized, double-blind, sham-controlled trial will evaluate the effects of perioperative taVNS on early postoperative recovery. Participants will be randomly assigned in a 1:1 ratio to receive active taVNS or sham stimulation. Each participant will receive three 30-minute stimulation sessions, scheduled 30-45 minutes before surgery, 6 ± 1 hours after surgery, and 18 ± 1 hours after surgery. All participants will receive standardized multimodal postoperative analgesia. The primary outcome will be the score on the 15-item Quality of Recovery (QoR-15) questionnaire at 24 hours after surgery. Secondary outcomes will include rescue opioid consumption expressed as oral morphine equivalents, pain scores measured using the Numeric Rating Scale (NRS), functional recovery, and adverse events. Conclusion: The investigators hypothesize that perioperative taVNS will improve early postoperative recovery quality after ACLR.
Gender: All
Ages: 18 Years - Any
Updated: 2026-10-29
NCT07093034
Sustained Auricular Nerve Stimulation for PVC Suppression
Non-invasive vagus nerve stimulation has been clinically tested for the treatment cardiac arrhythmias. However, prior studies have shown mixed results-possibly in part due to inadequate stimulation duration. Therefore, we have designed an investigator-initiated early feasibility study to evaluate safety, tolerability, and compliance with prolonged, nocturnal auricular nerve stimulation using the Parasym device.
Gender: All
Ages: 18 Years - Any
Updated: 2026-08-07
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