Clinical Research Directory

Clinical Significance of Internal Carotid Artery Dolichoarteriopathy

This observational study aims to investigate the clinical significance of internal carotid artery dolichoarteriopathy, including tortuosity, kinking, and coiling, and to identify factors associated with cerebral dysfunction and adverse cerebrovascular outcomes. The study combines retrospective clinical data with prospective follow-up of patients with verified internal carotid artery dolichoarteriopathy. Anatomical, hemodynamic, neuroimaging, clinical, cognitive, and biomarker characteristics will be evaluated to develop and validate a multimodal approach to risk stratification. Outcomes will also be compared between patients managed surgically and conservatively according to routine clinical indications. Treatment decisions are made independently by the treating physicians and are not assigned by the study protocol.