Clinical Research Directory

Immunotherapy in Neuroendocrine Carcinoma of the Cervix

This retrospective study reviews existing medical records. No new treatments or tests are given. The study asks how well immunotherapy worked for people with a rare cancer called neuroendocrine carcinoma of the cervix. Immunotherapy is a treatment that helps the body's immune system fight cancer. The investigators will review the records of approximately 150 participants treated with immunotherapy for this cancer. The study will evaluate: (1) how long participants lived without the cancer getting worse; (2) how long participants lived overall; (3) whether the cancer shrank or stopped growing; (4) what side effects occurred, especially immune-related side effects; and (5) whether certain tumor markers or different treatment plans made a difference. Participants will not be contacted or asked to complete any procedures. Only information already contained in medical records will be used. Names and other personal details will be removed to protect privacy. The study has been approved by the ethics committee at Peking Union Medical College Hospital. The results may help doctors choose the best treatment for patients with this rare cancer. Results will be shared in medical journals and at medical meetings. For patients and families: This study does not enroll new participants. Questions about this cancer or immunotherapy should be directed to a physician.

Multi-omics Study of Cervical Neuroendocrine Carcinoma

This is a retrospective study using archived tumor tissue and medical records from patients with cervical neuroendocrine carcinoma treated at Peking Union Medical College Hospital since January 1, 2015. Cervical neuroendocrine carcinoma is a rare and highly aggressive cervical cancer with no standard treatment. The study will analyze the tumor's genes, RNA, proteins, and immune environment to better understand its molecular features, identify molecular subtypes, find markers related to survival and immunotherapy, and build a prognostic prediction model. No new patients will be enrolled, and no additional tests or treatments will be given. About 80-120 patients are expected to be included. Results may help improve future diagnosis and personalized treatment for this rare cancer.

Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

The purpose of this study is to evaluate the safety, tolerability, dosimetry and preliminary efficacy of \[225Ac\]Ac-ETN029 and the safety and imaging properties of \[111In\]In-ETN029 in patients aged ≥ 18 years with locally advanced or metastatic DLL3 positive cancers.

Establishing a Tumor Registry for Patients With Neuroendocrine Carcinoma of the Cervix

This study collects information and data on patients with neuroendocrine cervical cancer. Information from this study may be used to better understand the correlation between clinical data, such as patient characteristics, treatment, and disease outcomes, and overall patient outcomes.