Clinical Research Directory

Lavender Inhalation for Anxiety in Patients Undergoing Coronary Angiography

This study evaluated the effects of lavender essential oil inhalation on anxiety, pulse rate, and blood pressure in patients undergoing coronary angiography. Participants were assigned to either the lavender inhalation group or the routine care control group in a 1:1 ratio by drawing lots. In the intervention group, three drops of lavender essential oil were applied to cotton placed in a small container approximately 30-40 cm from the patient. Inhalation continued during the waiting period before coronary angiography. The control group received routine care without aromatherapy. Anxiety was measured using the State Anxiety Inventory, and pulse rate and systolic and diastolic blood pressure were measured before the intervention and immediately after patients returned to the unit following coronary angiography.

CCTA-Based vs CAG-Based CABG: A Multicenter Pragmatic Non-Inferiority Trial

The goal of this clinical trial is to find out if using a non-invasive heart scan (called coronary computed tomography angiography, or CCTA) to plan coronary artery bypass grafting (CABG) works as well as the standard invasive approach (called coronary angiography, or CAG) for people with blocked heart arteries. The main questions it aims to answer are: Do people who have surgery planned with the non-invasive heart scan have similar health outcomes at 1 year as those who have surgery planned with the standard invasive approach? How does the non-invasive approach compare in terms of heart attacks, strokes, unplanned repeat procedures, and longer hospital stays? Researchers will compare two groups of participants. One group will have their surgery planned using only the CCTA . The other group will have their surgery planned using only the CAG. Both groups will undergo the CABG per local protocol. Participants will: Be randomly assigned (like flipping a coin) to one of the two planning approaches Undergo CABG as scheduled Return for follow-up visits at sugery days, 7 days, 1 month, 6 months, and 1 year after surgery Have a follow-up CCTA scan at 7 days and 1 year to check if the new bypass grafts are working well

The Effect of Virtual Reality Glasses on Vital Signs and State Anxiety in Patients Undergoing Coronary Angiography

Virtual reality (VR) is an effective, safe, and non-pharmacological intervention for reducing anxiety, with strong scientific evidence and no known adverse effects. By providing relaxation and distraction, VR suppresses sympathetic nervous system activity while enhancing parasympathetic activity, thereby promoting a relaxation response. VR immerses patients in a virtual environment, diverting attention from stressful clinical settings and reducing anxiety, fear, and worry. This psychological effect is accompanied by favorable physiological responses, including reductions in blood pressure (BP), heart rate (HR), and respiratory rate (RR), as well as improvements in peripheral oxygen saturation (SpO₂). Previous studies have demonstrated the effectiveness of VR in reducing preoperative anxiety across various clinical settings. For example, VR has been shown to decrease anxiety in adult patients undergoing sternotomy, reduce anxiety before maxillofacial surgery, and provide anxiety relief comparable to progressive muscle relaxation during arthroscopic knee surgery. These findings support the use of VR as an accessible and cost-effective intervention for anxiety management. In recent years, artificial intelligence (AI) has emerged as a valuable tool for analyzing complex clinical data and identifying patterns that may not be detected using conventional statistical methods. AI-supported analyses can integrate physiological measurements with patient-reported outcomes to provide a more comprehensive evaluation of intervention effectiveness. Despite growing evidence supporting VR interventions, no previous study has evaluated the effectiveness of VR in patients undergoing coronary angiography using both conventional outcome measures and AI-supported analytical approaches. Therefore, this randomized controlled study aims to investigate the effects of a VR intervention on state anxiety and vital signs in patients undergoing coronary angiography while applying AI-supported analyses to improve the evaluation of intervention effectiveness.

Virtual Reality During Coronary Angiography

This randomized controlled study was conducted to evaluate the effects of virtual reality application on pain, anxiety, vital signs, and comfort during coronary angiography. The findings provided evidence on non-pharmacological methods to improve patient comfort and reduce anxiety during invasive cardiac procedures.

Serpentine vs Traditional Hydrophilic Guidewire Tracking in Complex Radial Anatomy

Coronary angiography and angioplasty are commonly performed through the radial artery. In some patients, anatomical variations of the radial and brachial arteries, such as loops, increased tortuosity or sharp angulations may pose challenges to equipment advancement. Both the hydrophilic guidewire 0,035'' approach and the "Serpentine" technique have been described in the literature as techniques for overcoming radial anatomical challenges, with the hydrophilic guidewire approach being the more commonly used method. In practical terms, both techniques involve the use of the same standard materials, with differences relating mainly to operator handling and technical manipulation. This study does not introduce any experimental device, material, or treatment; instead, it aims to compare the established approach using a 0.035'' hydrophilic guidewire with the emerging " Serpentine" technique with respect to effectiveness, procedural time, and safety.

The Effect Of Paın And Anxıety Durıng Coronary Angıography

This research is a randomized controlled experimental study conducted to determine the effects of stress ball application and music playback during coronary angiography on patients' pain and anxiety levels and vital signs (systolic/diastolic blood pressure, pulse).

Effect of Virtual Reality Glasses on Stress, Muscle Tension, and Physiological Parameters Before Angiography

Today, cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Coronary angiography (CAG), a commonly used invasive procedure for diagnosing coronary artery disease, may trigger fear, stress, and anxiety in patients due to its invasive nature, lack of information, uncertainty, and the possibility of receiving a life-threatening diagnosis.These emotional responses activate stress mechanisms, leading to catecholamine release, increased heart rate, blood pressure, respiration, sweating, and muscle tension. Elevated stress can also cause lactic acid accumulation, increased oxygen demand, and muscular contraction, potentially resulting in coronary artery spasms or arrhythmias, and increasing procedural risks. Therefore, reducing stress before CAG is crucial to improving procedural outcomes and patient recovery. To address preoperative anxiety and stress, both pharmacologic and non-pharmacologic interventions are used. Among the non-pharmacologic options, virtual reality (VR) has emerged as an effective method to distract and calm patients, reducing anxiety, stress, and pain. Studies in various patient populations suggest VR glasses can be beneficial in managing psychological distress. However, no study has been found in the literature evaluating the effect of VR on stress-induced muscle tension in patients undergoing CAG. This gap highlights the potential contribution of this study to current knowledge. This study aims to investigate the effect of using VR glasses before coronary angiography on patients' stress levels, muscle tension, and selected physiological parameters.

Effect of Foot Massage After Coronary Angıography on Back Paın and Vıtal Sıgns

The aim of the study was to evaluate the effect of foot massage on patients' back pain and vital signs after coronary angiography. It is important for the transfer of nonpharmacological methods to clinical applications

Effects of White Noise and Earplugs on Patients' Physiological Parameters, Pain, Comfort and Procedure Satisfaction

Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Angiography (CAG) is an invasive method used in the diagnosis and treatment of CAD. Invasive methods such as coronary angiography cause pain. The sympathetic nervous system is stimulated and vital functions can be affected by the increased stress level of the pain experienced. In the angiography laboratory, patients are awake, aware of everything, and can easily hear the sounds of the monitor and the comments and conversations of the healthcare team. This auditory exposure can further trigger the patient's fear and anxiety and increase their pain. Increased anxiety can lead to an increase in the intensity of perceived pain and a decrease in pain tolerance. In addition to anxiety, catastrophizing such as fear of death can also be a means for disability and complications. In the literature, it is recommended to use nonpharmacological methods together with pharmacological treatment to increase pain tolerance and improve patient comfort and satisfaction in patients affected by invasive procedures. Nonpharmacological methods, unlike pharmacological agents, do not cause any harm to patients. It can help to keep physiological parameters such as blood pressure, respiration and pulse rate at normal levels and to increase comfort and satisfaction with the procedure. Sound therapy, which is a non-pharmacological method, turns the person's attention from negative stimuli to positive and hopeful feelings and can reduce stress, anxiety and pain. Non-pharmacological methods such as white noise therapy and using earplugs that prevent sound permeability can be used to distract the patient's attention from the source of stress and focus on other thoughts. It is suggested that patients exposed to 50 to 55 dB white noise experience pain relief and have an effect on heart rate and oxygen saturation (12). As a result of our literature review, no studies were found where white noise was applied during coronary angiography. This situation reveals the originality of our study. With white noise, the patient can be isolated from ambient sounds during the procedure and the stress experienced can be controlled, the increase in pain intensity and decrease in tolerance that may occur due to stress can be controlled, and the patient's comfort and satisfaction level during the procedure can be increased. We think that the patient's compliance during the procedure can be increased. The noise in the units affects the anxiety levels of the patients. The literature supports that the use of earplugs increases the comfort of the patient. In the study investigating the effect of auditory interventions on pain and comfort, it was determined that the pain level and heart rate were lower and the comfort level was higher in patients using earplugs compared to the control group. More evidence is needed on the effect of earplugs on physiological parameters, pain, comfort and procedure satisfaction of the patients by applying them to different patient groups. As a result of our literature review, no study was found where earplugs were applied during the coronary angiography procedure. This situation reveals another originality of our study. The nurse involved in every step of coronary angiography aims to ensure that the patient benefits from the procedure to a high extent and to increase the quality of the procedure by integrating innovative methods. Nursing practices that increase the quality of the procedure are included in national and international nursing care guidelines. Therefore, in order to implement quality nursing care, it is necessary to increase the number of randomized controlled experimental studies and to increase the level of evidence. The fact that our study was a pre-test post-test randomized controlled double-blind study will increase the level of evidence in this regard. This situation reveals another originality of our study. This study will use a randomized pre-test and post-test control group experimental design. It is planned that a total of 150 patients will participate in the study; 50 in the white noise group, 50 in the earplug group, and 50 in the control group. Data of the study will be collected via ''Personal information form, Numeric Pain Scale (NPS), Numeric Satisfaction Scale (NMS), Numeric Comfort Scale (NKS)''. A web-based randomization system will be used to determine the groups in the study. Pulse rate, respiratory rate, systolic blood pressure (SBP), diastolic blood pressure (DBP) and oxygen saturation values (SpO2) will be evaluated before, during, and after the procedure. Pain, satisfaction, and comfort levels will be evaluated at the end of the procedure. Interventions will be performed by the researcher and the patients will be observed throughout the intervention.