Clinical Research Directory

Timing, Trajectories and Prediction in Severe Dental Crowding: The Create SPACE (cSPACE)

Dental crowding is the most common malocclusion affecting up to 45% of the population and represents one of the leading reasons for seeking orthodontic treatment. Severe crowding may have a negatively impact on oral health related quality of life particularly psychosocial well-being and self-perceived dental appearance. In cases of severe crowding, extraction of four permanent teeth may be required to create sufficient space for proper alignment. Several treatment strategies are currently used, but there is a lack of scientific evidence regarding the optimal timing of tooth extraction and orthodontic treatment to achieve the best outcomes. The trial compare 1) late first premolar extraction with fixed orthodontic treatment, (2) early first premolar extraction with planned fixed orthodontic treatment, and (3) early first premolar extraction followed by observation, with fixed treatment provided only if indicated. The study will evaluate treatment need, occlusal outcomes, spontaneous dental development, patient-reported outcomes, adverse effects, treatment efficiency, and cost-effectiveness.

Self-ligating vs Conventional Brackets and Labial Bone Thickness During Crowding Correction in Adults

This randomized clinical trial compares two types of orthodontic brackets, self-ligating and conventional, in adults aged 18 to 25 with moderate crowding of the lower front teeth (4 to 8 mm). The main question is whether the type of bracket affects the thickness of the thin bone covering the front surface of the lower incisor roots (labial alveolar bone) during the leveling and alignment phase of treatment. Some clinicians claim that self-ligating brackets with light-force copper-nickel-titanium wires let the bone adapt and follow the teeth, while others report bone thinning with both systems. Twenty participants will be randomly assigned to self-ligating or conventional brackets. Bone thickness will be measured on cone beam computed tomography (CBCT) scans taken before treatment and at the end of leveling and alignment. The study will also compare the speed of alignment, changes in tooth inclination (torque and tip), pain, root resorption, and periodontal health between the two groups.

Effect of Different Adhesive Systems on White Spot Lesions During Fixed Orthodontic Treatment

The primary goal of this study is to compare the number of white spot lesions during fixed appliance therapy between self-etch and one-step bonding systems.