Clinical Research Directory

Effect of Apical Patency on Periapical Lesion Healing

This non-randomized clinical study aims to evaluate the effect of apical patency during root canal treatment on the healing of periapical lesions in maxillary anterior teeth. Participants will be assigned to either an apical patency group or a non-patency group. Changes in periapical lesion volume will be assessed using cone-beam computed tomography (CBCT) one year after treatment. The study aims to provide an objective volumetric assessment of the potential contribution of apical patency to periapical healing.

Antimicrobial Photodynamic Therapy in the Endodontic Treatment of Anterior Primary Teeth With Pulp Necrosis

This randomized controlled clinical trial evaluated the immediate reduction in intracanal microbial load and the short-term clinical and radiographic progression of anterior primary teeth with pulp necrosis after conventional endodontic treatment or antimicrobial photodynamic therapy (aPDT). Seven children aged 2 to 5 years contributed 20 eligible single-rooted anterior primary teeth. Teeth were randomized to conventional endodontic treatment (10 teeth) or aPDT (10 teeth). The primary outcome was intracanal microbial load before and immediately after the assigned first-session intervention. Clinical outcomes were assessed at 7 days, 1 month, and 3 months, and radiographic outcomes were assessed at 1 and 3 months.

Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals

The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.