Clinical Research Directory

Aspirin in Acute Pneumonia in the Elderly: a Multicenter, Double-blind, Randomized, Placebo-controlled Trial.

Acute pneumonia is a very common disease, and one of the leading causes of hospitalization and death in France. Almost a century after the discovery of penicillin, no major breakthrough has significantly reduced pneumonia-related mortality. While the choice of an appropriate antibiotic is decisive in the acute phase of the disease, the longer-term prognosis depends essentially on the worsening of other underlying pathologies, particularly in the elderly. In cured patients, excess mortality persists several months after the episode of pneumonia, due in particular to the onset of cardiovascular complications. Recent scientific literature shows an association between the prescription of cardio-protective drugs and survival after pneumonia. Older patients are usually excluded from interventional studies, so there are no specific recommendations for these patients at high risk of both acute pneumonia and cardiovascular events. The aim of this study is to assess the efficacy of low-dose aspirin therapy after pneumonia in preventing cardiovascular events in the elderly. The main objective is therefore to evaluate the impact of aspirin at a dose of 100mg per day on all-cause mortality at 90 days in patients over 75 years of age hospitalized for pneumonia.

Palliative Care Needs Among Elderly People at Emergency Department

Aim: To assess what proportion of all patients over the age of 75 who seek care at the emergency department have palliative care needs and whether these are documented in the patient's medical record. Data collection and analysis: Patients over 75 years of age who seek care in an emergency department and are classified as triage 2-4 during initial triage are assessed by a researcher. Patients with dementia or other cognitive dysfunction will be excluded. Two types of data collection are included 1) Swedish Palliative care guide (S-PCG) documents that the researcher fills in together with the patient, 2) data from the patient's medical record, this data is collected according to a special assessment template. Data from the medical record will be collected after the patient left the emergency department. Data collection is ongoing until 300 patients have been included in the study. Data will be analyzed using descriptive statistics. Implications: The percentage of previously undetected/documented palliative care needs in emergency departments is relevant for prioritizing general palliative care within e.g. housing for the elderly and primary care S-PCG can be relevant to increase the level of knowledge at these care facilities. If it turns out that many patients have palliative care needs that are not met in the emergency department, health care structures need to ensure that these patients receive help at the right level of care. This would likely mean that the number of emergency visits and hospital admissions (with suffering and reduced quality of life as a result) can be reduced.

Emotional Suppression in Elderly Individuals

The world's population is aging, and the proportion of individuals aged 60 and over is rapidly increasing. With aging, the prevalence of both physical and psychological health problems increases, negatively impacting quality of life. Chronic musculoskeletal pain, one of the most common health problems among older individuals, limits their daily activities and reduces their functional independence. Chronic pain is a complex experience that interacts not only with biological but also with psychological and social factors. In this context, an individual's emotional regulation strategies play a crucial role in understanding the pain experience. Emotional suppression, in particular, is defined as the conscious suppression or inability to express one's emotions. This strategy has been reported to be associated with increased psychological stress, anxiety, depression, and pain sensitivity in the long term. Individuals who suppress their emotions have been shown to perceive pain as more threatening and develop more negative coping strategies. Furthermore, cognitive tendencies such as pain catastrophizing, combined with emotional suppression, appear to increase an individual's psychological response to pain, impacting both pain intensity and psychological pain sensitivity. Such negative emotional regulation strategies can lead to increased pain perception and avoidance of physical activity, resulting in decreased physical performance. Physical performance in older individuals is one of the key indicators determining their level of independence and quality of life. Tests such as the Timed Up and Go Test, the 6-Minute Walk Test, and the 30-Second Sit-to-Stand Test are widely used to assess mobility, balance, lower extremity endurance, and overall physical fitness. Chronic pain and its accompanying emotional factors are known to negatively impact physical performance. However, studies examining the combined effects of emotional suppression on both pain perception and physical performance in older individuals are quite limited. This study contributes to the literature by offering a holistic assessment perspective by considering the physiological consequences of emotional regulation strategies in a multidimensional manner. Addressing the psychological and physical health of older individuals in conjunction is crucial for developing effective intervention programs. In this respect, the aim of the study was to examine the effect of the level of emotional suppression on pain perception (intensity and catastrophizing) and physical performance in elderly individuals.

Finger Food, Pleasure at Your Fingertips: Randomized Pilot Study, Open-label and Parallel Groups

Food is available in easy-to-grip bites that allow residents in care settings to use their fingers for food. This new way of eating can help limit weight loss, increase food intake, gain independence and improve the enjoyment of eating for residents.

Evaluation of the Concordance of Five Times Sit To Stand Results Between a Physical Consultation and a Teleconsultation

This study concerns elderly person aged more than 65 years with autonomous mobility. It is a multicentric randomized trial in two arms : Arm one : remote consultation then physical consultation Arm two : physical consultation then remote consultation Consultations consist to take a Five Times Sit To Stand test, in physical consultation with physiotherapist in the same room and in remote consultation with a physiotherapist in the next room to the patient.