Clinical Research Directory

Anesthetic Sensitivity Assessed by Alpha Band Power and Its Association With Emergence Time From Sevoflurane General Anesthesia in Young Adults.

The goal of this observational study is to determine the relationship between brain activity patterns and recovery time in adult patients (ages 35-50, ASA I-II) undergoing elective general anesthesia. The main question it aims to answer is: \- Does a lower magnitude of intraoperative alpha wave power correlate with a longer time for patients to emerge from general anesthesia? Participants will: * Undergo a standardized general anesthesia (GA) protocol for elective surgery. * Have their EEG activity recorded using a standard clinical BIS™ anesthetic depth monitor during the procedure. * Have their time to awakening precisely measured after the cessation of anesthetic gases.

Controlled Ventilation During Anesthetic Emergence

Absolutely - for a \*\*ClinicalTrials.gov-style Brief Summary\*\*, I'd keep it simple and patient-friendly like your example: The goal of this clinical trial is to learn whether maintaining controlled mechanical ventilation during emergence from general anesthesia can improve the quality and safety of recovery compared with conventional supported weaning in adults undergoing surgery with a breathing tube. The main questions it aims to answer are: * Does controlled mechanical ventilation during emergence reduce coughing and the duration of coughing before removal of the breathing tube? * Does it reduce agitation during emergence from anesthesia? * Does it reduce the need for breathing support, such as continuous positive airway pressure (CPAP), after removal of the breathing tube? * Are there differences in oxygen levels, blood pressure, heart rate, airway complications, or the time required for removal of the breathing tube? Researchers will compare controlled mechanical ventilation with conventional supported weaning during emergence from general anesthesia. Participants will: * Receive general anesthesia with a breathing tube for their planned surgery * Be assigned to either controlled mechanical ventilation or conventional supported weaning during emergence from anesthesia * Have their coughing, agitation, oxygen levels, blood pressure, heart rate, and airway-related events monitored during emergence * Have the time to removal of the breathing tube and any need for additional breathing support recorded This version is deliberately written in \*\*plain language rather than manuscript language\*\*, which is much closer to what ClinicalTrials.gov expects for the brief summary.

Electroencephalographic Trajectories During Emergence From Inhalational and Total Intravenous Anesthesia

General anesthesia emergence is a critical transition during which patients recover from an anesthetic-induced unconscious state to consciousness. This period is associated with various early postoperative complications, including emergence agitation, postoperative nausea and vomiting, delayed recovery, and impaired recovery quality in the Post-Anesthesia Care Unit (PACU). Although total intravenous anesthesia (TIVA) and inhalational anesthesia (IA) are widely used maintenance strategies, differences in their effects on cerebral recovery patterns during emergence remain incompletely understood. Conventional assessments of emergence, such as time to eye opening, extubation time, and clinical sedation assessments, mainly reflect behavioral recovery and cannot directly characterize the dynamic process of cerebral functional recovery. Electroencephalography (EEG) provides continuous and non-invasive measurement of cortical activity and may enable objective characterization of anesthetic emergence. Previous studies suggest that emergence from anesthesia involves dynamic transitions among distinct EEG states rather than a simple reversal of anesthetic induction, and specific EEG trajectories may be associated with abnormal emergence and PACU delirium. Therefore, this single-center prospective observational cohort study aims to continuously collect emergence-phase EEG data from patients receiving TIVA or IA without altering clinical anesthesia management. The study will compare EEG trajectory characteristics, spectral features, and aperiodic parameters between different anesthesia maintenance modalities and explore their associations with emergence quality and early postoperative complications. This study may provide further insights into neurophysiological patterns of anesthetic emergence and support future optimization of emergence monitoring and perioperative management.

Comparison Between Total Intravenous Anesthesia With Magnesium Sulphate Versus Total Intravenous Anesthesia With Dexmedetomidine in Patients Undergoing Lumbar Spine Surgeries

Although total intravenous anesthesia (TIVA) provides advantages such as accelerated recuperation and diminished postoperative nausea, it also has constraints, such as the potential for hemodynamic instability and inadequate analgesia. TIVA is less suitable for major surgeries, particularly those involving the spine, when used alone, due to these limitations, as they necessitate substantial muscle relaxation and pain management. A non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, magnesium sulfate (MgSO4), exhibits antinociceptive properties. The infusion of Magnesium during general anesthesia has been shown to decrease the need for anesthesia and the consumption of postoperative analgesics in numerous clinical studies. MgSO4, when utilized as an adjunct to TIVA, has been demonstrated to decrease the duration of extubation, facilitate earlier emergence from anesthesia, and facilitate intraoperative neurophysiological monitoring (IOM) during spine surgery. Dexmedetomidine is a selective α2-adrenoreceptor agonist whose sedative effects are predominantly mediated by its action on α-2 adrenergic receptors in the brain and spinal cord. It delivers efficient sedation without the pronounced respiratory depression that is frequently observed with other sedatives. Dexmedetomidine induces a profound sense of tranquility and alleviates anxiety by selectively targeting specific receptors in the central nervous system, in addition to offering analgesic advantages. Dexmedetomidine has been employed in the surgical intensive care unit to expedite the extubation process. Dexmedetomidine is now being utilized more frequently as an adjuvant for propofol-based TIVA in procedures that necessitateintraoperative neurophysiological monitoring. There is a paucity of literature comparing TIVA with magnesium sulphate and TIVA with dexmedetomidine in spine surgeries.

Efficacy of Ultrasound-guided Greater Auricular Nerve Block in Preventing Postoperative Emergence Agitation in Pediatric Patients Undergoing Microscopic Middle Ear Surgery.

This study is designed to evaluate the effectiveness of ultrasound-guided greater auricular nerve block (GAN) on the reduction of emergence agitation (EA) occurrence and EA severity in children who are receiving general anesthesia for a microscopic middle ear operation.