Clinical Research Directory

Flap Assessment With Regional Oximetry for Early Detection of Compromise in Free Flap Reconstructive Surgery - FLARE Study

After some operations in which tissue is removed, it is necessary to repair the defect with a piece of tissue from another location in the body. This is called a microsurgically transplanted tissue flap (or tissue flap, for short). It is important that, after an operation, enough blood flows to the relocated tissue. In this study, we want to investigate whether, after the operation, measuring oxygen in the tissue flap with the INVOS 7100c device helps detect blood flow problems earlier. In the future, this could help doctors intervene more quickly, thereby reducing the risk of complications.

Effect of Dexmedetomidine on Microsurgery Reconstruction in Cancer Patient

This double-blinded randomized controlled trial aims to investigate the effect of intraoperative dexmedetomidine administration on early flap viability and microvascular integrity in cancer patients undergoing elective microvascular reconstructive surgery. The primary outcome is clinical flap viability within 48 hours postoperatively, assessed using a standardized scoring system based on flap color, temperature, capillary refill time, and tissue turgor. Secondary outcomes include the evaluation of biomarkers related to endothelial glycocalyx degradation (syndecan-1), oxidative stress (SOD-1), inflammation (IL-6, IL-10), thrombosis (PAI-1), and angiogenesis (VEGF), as well as microcirculatory assessment using Sidestream Dark Field (SDF) imaging. The study is designed to determine whether dexmedetomidine improves early surgical outcomes by modulating pathophysiological processes involved in microvascular flap success.