Clinical Research Directory
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3 clinical studies listed.
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Tundra lists 3 HSIL, High Grade Squamous Intraepithelial Lesion clinical trials. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.
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NCT06949800
CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial
This study is focused on treatment of anal high-grade squamous intraepithelial lesions (HSIL) in persons with HIV (PWH), with the ultimate goal of applying the approach toward prevention of anal cancer in this population
Gender: All
Ages: 21 Years - Any
Updated: 2026-10-29
2 states
NCT07895641
Predictive Biomarkers for Precision Management of Pre-cancerous Cervical Neoplasia
The goal of this observational study (retrospective cohort study) is to determine whether DNA methylation status in archived cervical cytology samples can predict regression, persistence, or progression of high-grade cervical dysplasia (HSIL/CIN2-3) in women who have previously undergone clinical management and follow-up. The main questions it aims to answer are: Can methylation status in archived cervical cytology samples predict histologic regression of HSIL (CIN2/3)? Does the addition of clinical factors, screening history, smoking status, and HPV genotype improve the predictive ability of methylation markers for disease regression, persistence, or progression? Researchers will compare: Women whose lesions regressed with women whose lesions persisted or progressed. Methylation-positive and methylation-negative samples to assess whether methylation status is associated with subsequent clinical outcomes. Participants will: Be identified retrospectively from women aged 23 to 70 years who were previously diagnosed with HSIL/CIN2-3 and managed according to routine clinical practice. Have archived cervical cytology samples retrieved from biobanks for DNA methylation analysis. Contribute existing clinical, cytological, histological, and HPV data collected during routine care. Contribute existing follow-up data from medical records, including outcomes such as regression, persistence, progression, and treatment results. No additional interventions, testing, or follow-up visits will be performed as part of the study; all analyses will be based on retrospectively collected biological samples and clinical data.
Gender: FEMALE
Ages: 23 Years - 70 Years
Updated: 2026-10-26
NCT07306260
Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical HSIL/CIN2
This study evaluates the efficacy and safety of ALA-PDT versus LEEP in treating cervical HSIL/CIN2, aiming to demonstrate non-inferiority in clinical efficacy.
Gender: FEMALE
Ages: 25 Years - 65 Years
Updated: 2026-10-14
1 state