Clinical Research Directory

ACUTE EFFECTS OF HIGH-INTENSITY LASER THERAPY ON PAIN, MUSCLE STIFFNESS, AND GRIP STRENGTH IN HEALTHY ADULTS

The goal of this clinical trial is to learn whether high-intensity laser therapy applied before exercise reduces the loss of handgrip strength, muscle stiffness, and pain after a tiring forearm exercise in healthy adults. This therapy delivers laser light through the skin to the underlying tissues. The main questions this study aims to answer are: Does laser therapy reduce the loss of handgrip strength after exercise compared with placebo treatment? Does laser therapy reduce the increase in forearm muscle stiffness after exercise? Does laser therapy reduce pain after exercise? Researchers will compare active laser therapy with placebo laser treatment to assess whether the active treatment affects the muscles' response to exercise. Each participant will receive both treatments on separate visits. The order of treatments will be assigned by chance. Participants will attend two laboratory visits at the Faculty of Health Sciences, University of Primorska, Slovenia. At one visit, they will receive active laser therapy over the muscles that bend the wrist in their dominant forearm. At the other visit, they will receive placebo treatment over the same area. At each visit, participants will: Rest before the initial measurements. Have their handgrip strength, forearm muscle stiffness, and pain measured before treatment. Receive active laser therapy or placebo treatment. Wait five minutes before starting the exercise procedure. Complete a wrist-strength test, then hold a muscle contraction at half of their maximum wrist-bending strength until they can no longer maintain the required force. Have their handgrip strength, muscle stiffness, and pain measured again immediately after exercise and five and fifteen minutes later. Handgrip strength will be measured by squeezing a handheld device. Muscle stiffness will be measured using a device that applies a brief, gentle mechanical tap to the skin over the muscle. Participants will rate their pain using a visual scale. Participants will be asked to avoid strenuous physical activity for at least 24 hours before each visit and to keep their diet and regular supplement use similar before both visits. The main outcome is the change in handgrip strength from before treatment to after exercise. Changes in muscle stiffness and pain will also be compared between the two treatments. Researchers expect active laser therapy to result in a smaller decrease in handgrip strength and smaller increases in muscle stiffness and pain than placebo treatment.

Pharmacokinetic Characteristics, Safety, and Immunogenicity of HLX29 Compared With HLX11

This is a randomized, double-blind, parallel-controlled study to compare the PK profile of HLX29 and HLX11 and evaluate their safety, tolerability, and immunogenicity after a single intravenous dose in healthy male adult participants.

Circadian Rhythm and Cardiovascular Recovery After Submaximal Exercise

This cross-sectional, observational, and analytical study aims to investigate the relationship between morningness-eveningness characteristics and cardiovascular recovery after a submaximal exercise test in healthy individuals aged 18-45 years. Circadian preference will be assessed using the Morningness-Eveningness Questionnaire, sleep quality will be assessed using the Pittsburgh Sleep Quality Index, and cardiovascular recovery will be evaluated following the 6-Minute Walk Test

Mindfulness Intervention for Maltreatment-Related Cognitive Decline

The goal of this clinical trial is to examine whether an online mindfulness-based training program can help improve cognitive function including attention, emotional regulation, and mental health (such as depression and anxiety) in young adults (ages 19 to 40) who have experienced maltreatment. The main questions it aims to answer are: * Can a 4-week online mindfulness program improve cognitive function including attention in adults with a history of maltreatment? * Does the program reduce symptoms of depression and anxiety compared to a control group? Researchers will compare a mindfulness training group with a waiting-list control group to see if the intervention leads to improvements in psychological and cognitive functioning. Participants will: * Complete psychological and cognitive assessments before and after the 4-week period * Watch weekly online educational and mindfulness practice videos (e.g., breathing, body scan, walking meditation) * Perform weekly mindfulness-based assignments through a study website * Engage in optional interaction via a chat channel

Sleep Quality, Adiposity and Diet Quality

The aim of this study is to evaluate the effects of sleep quality on cardiovascular disease risk and food and nutrient intakes. Within the scope of this study, several parameters associated with cardiovascular disease risk will be assessed, including waist circumference, hip circumference, waist-to-hip ratio, waist-to-height ratio, triceps skinfold thickness, mid-upper arm circumference, and serum levels of glucose, HbA1c, insulin, LDL cholesterol, HDL cholesterol, total cholesterol, homocysteine, and lipoprotein(a). Cardiovascular disease risk will be evaluated using the Framingham Risk Score, SCORE2, and A Body Shape Index (ABSI). To assess visceral adiposity, a formula incorporating waist circumference and serum triglyceride and HDL cholesterol levels will be used. In addition, participants' body fat and muscle percentages will be determined. Carbohydrate, fat, protein, vitamin, mineral, and fluid intakes will also be compared between individuals with poor and good sleep quality, and the effects of sleep quality on nutrient intake will be evaluated. Previous studies investigating the effects of sleep quality on diabetes or cardiovascular diseases have predominantly been conducted among middle-aged adults aged 50 years and older, a population with a higher prevalence of dysglycemia, dyslipidemia, and hypertension. In the present project, all eligible adults aged 18 years and older will be evaluated. Furthermore, to our knowledge, no previous study has comprehensively evaluated the effects of sleep quality on cardiovascular disease risk together with nutrient intakes among individuals with type 2 diabetes. This study is expected to contribute to the literature by evaluating the effects of sleep quality on cardiovascular disease risk among individuals with type 2 diabetes. In addition, the extent to which sleep quality is associated with dietary habits will be examined at the level of nutrient intake. The findings of this study may provide a basis for educational interventions aimed at emphasizing the importance of sleep quality and improving sleep quality, as well as for future public health initiatives. Improving sleep quality may also contribute to strategies aimed at preventing the development of type 2 diabetes and improving the management of its complications.

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Orally Administered TIX100 in Healthy Subjects

Randomized, Placebo-controlled Study to determine the safety and tolerability of multiple oral doses of TIX100 administered daily for 28 days to otherwise healthy overweight/obese subjects.

Balance Performance and Quality of Life in Parkinson's Disease

This observational study aims to examine the relationship between performance-based balance test results and quality of life in individuals with Parkinson's disease. It also seeks to determine which balance test best explains quality of life in this population. Balance and functional performance will be assessed using the Six Spot Step Test, 30-Second Chair Stand Test, Timed Up and Go Test, Four Square Step Test, Berg Balance Scale, and 3-Meter Backward Walk Test. Quality of life will be evaluated using the 39-item Parkinson's Disease Questionnaire (PDQ-39). The findings may help clinicians select appropriate assessment methods and develop rehabilitation programs that address the factors associated with quality of life in individuals with Parkinson's disease.

Effect of Different Currents for Transcranial Modulation of the Sensorimotor Corticospinal Pathway in Healthy Subjects

Transcranial modulation of the corticospinal sensorimotor pathway is a promising approach in neuroscientic functions. Among the techniques used, transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS) and the application of random noise current stand out. Objective: To compare the e stimulus, in the EEG frequency bands, on Motor Evoked Potentials (MEP) and on the functional activation of the motor cortex, assessed by Functional Near Infrared Spectroscopy (fNIRS) and pain measurements in healthy subjects subjected to a standardized algogenic stimulus. Subjects and Method: This is a randomized, double-blind, controlled and crossover clinical trial, involving the inclusion of 14 healthy male subjects, with complete secondary education, aged between 18 and 40. years. Participants will be randomized to receive Transcranial Direct Current Stimulation (tDCS), (2) Transcranial Alternating Current Stimulation (tACs), (3) Random Noise Current, (4) Simulated Stimulation Session and (5) Rest Session. Experimental conditions will take place in a standard, quiet and bright room. Assessments will include Motor Evoked Potential, Heat Pain Threshold, Motor Area Activation through metabolic activation measured by fNIRS and analysis of EEG frequency waves. After the baseline assessment, participants will undergo a session of transcranial stimulation, followed by an algogenic stimulus with water at zero degrees, immersion of the dominant hand for 1 minute, with rest intervals of 3 minutes between each of the four serial stimuli. After this stimulus session, outcome measurements will be carried out. Expected results: This clinical trial is expected to provide insights into how tDCS, tACs and random stimulation in to an algogenic stimulus. The results may contribute to the development of therapeutic or neuromodulation strategies in clinical conditions where the regulation of the cortico-spinal sensorimotor pathway is relevant.

A Phase I Study of HXN5003 in Healthy Participants and Patients With Moderate-to-Severe Atopic Dermatitis

This is a Phase I, multicenter, randomized, double-blind, placebo-controlled study evaluating HXN5003 in healthy participants and patients with moderate-to-severe atopic dermatitis (AD). The study consists of two parts: Part A (single ascending dose in healthy participants) and Part B (multiple ascending dose in AD patients). The primary objectives are to assess the safety, tolerability, pharmacokinetics (PK), immunogenicity, and preliminary efficacy of HXN5003.

French Military Firefighters to Assess Relationships Between Exposome and Health.

The aim of the study is to describe professional exposures and health events among French military firefighters (both active-duty personnel and veterans) and identify potential relationships between the exposome (the total history of occupational and personal exposures) and health status in these populations. The study is based on a self-administered questionnaire that collects retrospective and present information about exposures and health conditions.

Thrower's Ten Versus Conventional Conditioning in Amateur Discus Throwers

This retrospective observational study compares the association of Thrower's Ten training and conventional conditioning with throwing performance and shoulder muscle strength in amateur male discus throwers. The study uses previously completed training and performance records from athletes who participated in one of two conditioning programmes. Throwing distance and shoulder muscle strength were assessed at baseline, during the training period, and at the end of the training period. The primary outcome is change in discus-throwing distance. Secondary outcomes include changes in shoulder muscle strength. The study aims to determine whether athletes who participated in the Thrower's Ten programme showed different changes in throwing performance and shoulder strength compared with athletes who participated in conventional conditioning.

Study of HXN6005 in Healthy Participants and Patients With Moderate-to-Severe Atopic Dermatitis

This is a Phase I/II, multicenter, randomized, double-blind, placebo-controlled study evaluating HXN6005 in healthy participants and patients with moderate-to-severe atopic dermatitis (AD). The study consists of three parts: Part A (single ascending dose in healthy participants), Part B (multiple ascending dose in AD patients), and Part C (multiple-dose efficacy and safety assessment in AD patients). The primary objectives are to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of HXN6005.

Eight-week Sports Injury Prevention Program

This study aims to find out whether an 8-week sports injury prevention program can improve lower-body performance-such as power, agility, and balance-among female college athletes in Saudi Arabia. Sports participation has increased among women in Saudi Arabia, but many injury-prevention programs were originally designed for male athletes and may not meet the specific needs of females. This study will help determine whether a tailored program can reduce injury risks and improve athletic performance. Female athletes aged 18-35 years who have been training and competing for at least one year can participate. Athletes with recent injuries, pregnancy, or chronic medical conditions that could affect performance will not be included. Participants will complete tests before and after the program, including jumping, balance, and agility assessments. The prevention program includes warm-up exercises, stretching, strengthening, jumping drills, balance work, and agility training. By comparing results before and after the program, the study will show whether this type of training can help female athletes stay safer and perform better.

Effect of Magnesium Supplementation on Sleep Quality and Cognitive Function in Saudi Adults

The goal of this clinical trial was to evaluate whether magnesium citrate supplementation improved sleep quality and cognitive function in healthy Saudi adults. It also assessed the effects of magnesium on selected blood markers. The main questions it aimed to answer were: Did magnesium supplementation improve sleep quality? Did magnesium supplementation improve cognitive function? Researchers compared participants who received magnesium citrate to a control group that did not receive any intervention to evaluate its effects. Participants: Took magnesium citrate (400 mg daily) for 90 days (two capsules: one in the afternoon and one 1-2 hours before bedtime) Visited Umm Al-Qura University twice (before and after the intervention) for: Sleep quality assessment Cognitive function assessment Blood sample collection to measure serum magnesium and HbA1c The control group did not receive any supplementation during the study period.

Does Style Matter: Comparison of Moderate- to Low-intensity Styles of Yoga

The goal of this clinical trial is to learn if yoga works to improve sleep and heart health in adults with and without insomnia disorder. The main questions it aims to answer are: * Does the style of yoga impact participants heart health overnight? * Does the style of yoga improve participants sleep following a single session? Researchers will compare adults with insomnia disorder to adults with healthy sleep . Participants will: * Complete a moderate-intensity yoga practice, a low-intensity intensity yoga practice, and a quiet rest period while watching a nature documentary in the evening on three separate evenings * Participants will have their sleep and heart health measured using a watch and heart rate monitor overnight following each visit

A Study of JPH034 in Healthy Adult Participants

This study is designed to evaluate the safety, tolerability, and PK of JPH034 and identify side effects that occur in healthy participants between the ages of 18 and 50 years. Participants enrolling in the trial will be randomly assigned to receive JPH034 or placebo. Participants in the in single-ascending dose (SAD) cohorts will receive treatment once, and one group of participants will receive treatment a second time to study the effects of food. Health measurements including physical examinations, vital signs, ECGs, and safety laboratory tests will be performed to monitor safety. Blood tests will be performed to measure how much JPH034 and its major metabolite (M1) gets into the bloodstream and how long it stays in the body.

Acute Changes in Gastrocnemius Muscle Stiffness

This study evaluated how different exercise and rest schedules during calf-raise exercise affected the stiffness of the calf muscle in trained volleyball athletes. It also examined how muscle stiffness changed during a five-minute recovery period in which percussive therapy was applied. Thirty volleyball athletes, including 15 women and 15 men, completed three exercise sessions in a randomized order. During each session, participants performed repeated calf raises for a total period of five minutes using one of three work-to-rest schedules: 30 seconds of exercise followed by 30 seconds of rest, 15 seconds of exercise followed by 45 seconds of rest, or 45 seconds of exercise followed by 15 seconds of rest. The stiffness of the medial gastrocnemius, one of the main calf muscles, was measured using shear-wave elastography. Measurements were taken before exercise, immediately after exercise, and after the five-minute percussive therapy recovery period.

Dose-response Effects of Dietary Nitrate on Running Time-to-exhaustion and Neuromuscular Fatigue: a Randomized Crossover Exploratory Pilot Study

Background: Dietary nitrate is a natural compound found in vegetables such as beetroot and leafy greens. Previous research suggests that consuming nitrate before exercise may improve endurance and physical performance. However, it is still unclear whether higher doses provide greater benefits, particularly in recreationally trained individuals. Purpose: This study aimed to investigate whether different doses of dietary nitrate taken before exercise influence endurance performance and muscle fatigue during a running test in recreationally trained men. Methods: This randomized, double-blind, placebo-controlled crossover pilot study compared the effects of a placebo and three different doses of dietary nitrate consumed before exercise. On separate occasions, participants completed the same treadmill running test to exhaustion after ingesting the assigned supplement. Measures of muscle performance, blood lactate concentration, and perceived exertion were collected before and after exercise to evaluate the effects of dietary nitrate supplementation.

Movement Quality and Mechanical Properties of the Muscle

Movement quality is considered a comprehensive indicator of neuromuscular control, segmental stability, and efficient force transmission, and is recognized as an important determinant of musculoskeletal health and functional performance. Optimal movement patterns help distribute joint loading appropriately, whereas suboptimal movement strategies may contribute to increased biomechanical stress and the development of overuse injuries over time. In recent years, the passive mechanical properties of muscle (stiffness, tone, and elasticity) have been suggested to influence segmental stability and movement control; however, the relationship between these variables has not been sufficiently investigated in healthy populations. The aim of this study is to examine the association between movement quality and the passive mechanical properties of skeletal muscle in healthy adults. Healthy adult individuals will be included in the study. The sample size was determined based on a priori power analysis, and a total of 42 participants will be recruited. Movement quality will be assessed using the Functional Movement Screen (FMS). The FMS is a standardized screening tool consisting of seven fundamental movement tasks designed to evaluate basic movement patterns. Each task will be scored on a scale from 0 to 3, and the total score (0-21 points) will be used as an indicator of overall movement quality. The passive mechanical properties of muscle (stiffness, tone, and elasticity) will be measured using a portable and non-invasive device, the MyotonPRO 5, from the quadriceps, hamstring, gastrocnemius, tibialis anterior, and erector spinae muscles. Measurements will be performed at standardized anatomical reference points with the muscle in a relaxed position. The device probe will be placed perpendicular to the skin surface over the muscle, and the passive viscoelastic response of the tissue will be recorded. The relationship between variables will be analyzed using Pearson or Spearman correlation analysis, depending on data distribution characteristics.

Factors Affecting Physical Activity Levels and Preferences

Physical inactivity is a major public health challenge and is associated with an increased risk of chronic diseases, reduced quality of life, and increased healthcare costs. Although the benefits of regular physical activity are well established, physical inactivity remains highly prevalent worldwide. Understanding the factors associated with physical activity participation is essential for developing effective public health strategies. This study investigated the factors associated with physical activity levels and preferences among adults in Türkiye. The findings provide evidence regarding demographic, behavioral, and psychosocial factors associated with physical activity participation and may contribute to the development of targeted interventions to promote physically active lifestyles.

An Early-stage Clinical Trial to Evaluate the Safety, Absorption, and Disposition of YR001 Ointment Following Topical Application on the Skin of Healthy Chinese Subjects

The goal of this clinical trial is to evaluate the safety, local tolerability, and pharmacokinetic (PK) profile of YR001 Topical Ointment in healthy Chinese participants. This is a first-in-China, Phase I study designed to assess the drug's systemic absorption and disposition following single and multiple topical applications. The main questions it aims to answer are: What is the safety and local tolerability profile of YR001 Topical Ointment after single-dose and multiple-dose administration in healthy Chinese participants? What are the pharmacokinetic characteristics (e.g., plasma drug concentrations) of YR001 Topical Ointment after single and multiple topical applications? Researchers will compare participants receiving YR001 Topical Ointment with participants receiving vehicle (placebo) to determine whether the safety profile and local tolerability of YR001 are comparable to placebo. Participants will: Receive topical application of either YR001 Topical Ointment or matching placebo (vehicle) on approximately 10% or 20% of their body surface area, depending on the assigned group Undergo serial blood sampling for pharmacokinetic assessments at specified time points before and after drug administration Complete safety evaluations including physical examinations, vital signs, laboratory tests (hematology, biochemistry, coagulation, thyroid function, urinalysis), 12-lead ECGs, and local tolerability assessments at the application site Remain in the clinical unit for specified periods during the dosing and follow-up phases, with total study participation duration up to approximately 30 days per participant

Prefrontal Neuroplasticity and Coping Strategies in Healthy Population

The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS) induces immediate changes in prefrontal excitability in healthy individuals, compared to sham stimulation. In this randomized, sham-controlled trial, investigators will assess several psychological measures-including the Perceived Stress Scale and the Coping Inventory for Stressful Situations-to explore how stress levels and coping strategies relate to immediate prefrontal cortex (PFC) activity changes following TBS.

Assessment of Pressure Pain Threshold (PPT) and Conditioned Pain Modulation (CPM) After Effect in Patients With and Without Tennis Elbow (TE)

This study at Hashemite University looks at how people with and without tennis elbow (AKA lateral elbow tendinopathy) feel pressure pain and how their bodies briefly "turn down" pain after a cold stimulus. Participants complete brief questionnaires (basic demographics without names, a tennis-elbow symptom form, and a physical-activity form) and then have their pressure-pain threshold (PPT) tested with a handheld device that slowly increases pressure on standard spots near the elbow and wrist; they say when it first becomes painful. To test the body's built-in anti-pain system (conditioned pain modulation, CPM), one hand is placed in ice water (the cold-pressor task) and PPT is measured again at set times (before, during, and after the cold stimulus) to see how much pain sensitivity changes and how long that change lasts. Both PPT reliability and CPM after effect are measured in this study. The study findings may help improve future assessment and treatment of musculoskeletal pain conditions.

A Study to Evaluate ENERGI-F705 Tablets in Healthy Volunteers

To evaluate the safety, the tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) of ENERGI-F705 Tablets in healthy subjects.