Clinical Research Directory

Food Supplement for Longevity

As we age, the cells in our body gradually lose their ability to produce energy efficiently and repair damage. This process, known as cellular ageing, is linked to lower levels of a molecule called Nicotinamide Adenine Dinucleotide (NAD⁺), which is essential for energy production and maintaining healthy cell function. Other factors, such as reduced antioxidant capacity and mitochondrial decline, also contribute to ageing. This study will explore whether a daily food supplement, taken for one month, can improve markers of cellular health in adults aged 35 and over. Thrive⁺ contains ingredients that may support energy metabolism and antioxidant defences, including compounds that boost NAD⁺ levels and Coenzyme Q10 (CoQ10), which helps cells produce energy. It also includes resveratrol, a plant compound thought to promote healthy ageing. The research will take place at The Functional Gut Clinic in Manchester and will involve 15 healthy volunteers. Participants will attend two clinic visits: one at the start and one after 30 days of supplementation. At each visit, participants will have blood tests, blood pressure and heart rhythm checks, a simple grip strength test, and complete short questionnaires on mood and wellbeing. Women of childbearing potential will also have a pregnancy test. The supplement will be taken as one capsule per day for 30 days. The main question is whether the supplement increases NAD⁺ levels in the blood. The investigators will also look at other markers, such as antioxidant status, inflammation, and physical measures like grip strength. The study aims to provide insight into whether supplementation can support healthy ageing in everyday life.

Oura Ring OA15 Validation

The current study intends to collect data from Oura Ring time-locked to ground truth medical sleep diagnostic gold-standard polysomnography (PSG) for product research and development, investigational algorithm validation, and scientific dissemination.

Magnetic Field Maps With NV Application Kit MCG

This prospective, single-center, exploratory feasibility study investigates the use of diamond-based nitrogen-vacancy (NV) magnetometers for non-invasive magnetocardiography (MCG). The goal is to assess whether highly sensitive NV sensors can reliably detect and reconstruct the weak magnetic fields generated by the human heart and evaluate their potential for future cardiac diagnostics.

ACUTE EFFECTS OF HIGH-INTENSITY LASER THERAPY ON PAIN, MUSCLE STIFFNESS, AND GRIP STRENGTH IN HEALTHY ADULTS

The goal of this clinical trial is to learn whether high-intensity laser therapy applied before exercise reduces the loss of handgrip strength, muscle stiffness, and pain after a tiring forearm exercise in healthy adults. This therapy delivers laser light through the skin to the underlying tissues. The main questions this study aims to answer are: Does laser therapy reduce the loss of handgrip strength after exercise compared with placebo treatment? Does laser therapy reduce the increase in forearm muscle stiffness after exercise? Does laser therapy reduce pain after exercise? Researchers will compare active laser therapy with placebo laser treatment to assess whether the active treatment affects the muscles' response to exercise. Each participant will receive both treatments on separate visits. The order of treatments will be assigned by chance. Participants will attend two laboratory visits at the Faculty of Health Sciences, University of Primorska, Slovenia. At one visit, they will receive active laser therapy over the muscles that bend the wrist in their dominant forearm. At the other visit, they will receive placebo treatment over the same area. At each visit, participants will: Rest before the initial measurements. Have their handgrip strength, forearm muscle stiffness, and pain measured before treatment. Receive active laser therapy or placebo treatment. Wait five minutes before starting the exercise procedure. Complete a wrist-strength test, then hold a muscle contraction at half of their maximum wrist-bending strength until they can no longer maintain the required force. Have their handgrip strength, muscle stiffness, and pain measured again immediately after exercise and five and fifteen minutes later. Handgrip strength will be measured by squeezing a handheld device. Muscle stiffness will be measured using a device that applies a brief, gentle mechanical tap to the skin over the muscle. Participants will rate their pain using a visual scale. Participants will be asked to avoid strenuous physical activity for at least 24 hours before each visit and to keep their diet and regular supplement use similar before both visits. The main outcome is the change in handgrip strength from before treatment to after exercise. Changes in muscle stiffness and pain will also be compared between the two treatments. Researchers expect active laser therapy to result in a smaller decrease in handgrip strength and smaller increases in muscle stiffness and pain than placebo treatment.

Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism

The goal of this clinical trial is to learn how nicotinamide riboside (NR), a form of vitamin B3, affects brain energy metabolism in healthy adults. Researchers want to find out if taking NR by mouth for 2 weeks can raise the balance of two related brain chemicals called NAD+ and NADH, which play a key role in how cells make and use energy. The main questions are: Does short term NR treatment increase the NAD+ to NADH ratio in the brain, and does it change other brain energy measures that we can see with a special type of MRI scan called phosphorus 31 MR spectroscopy. Adults between 18 and 65 years old who are generally healthy and do not have a personal or close family history of mood or psychotic disorders may be able to take part. People who join the study will first have a screening visit with a psychiatric interview and safety checks to confirm they are eligible and to review the risks and procedures. Eligible participants will then have a baseline visit that includes a blood draw, vital signs, urine drug and pregnancy tests when needed, and a 7 Tesla MRI/MRS scan focused on brain chemistry and structure. After the baseline visit, participants will take NR capsules by mouth at home, 1500 milligrams in the morning and 1500 milligrams in the early afternoon each day, for about 2 weeks, for a total daily dose of 3000 milligrams. They will be asked to avoid alcohol and other drugs during the study and to complete a short food diary near the end of the dosing period so that researchers can track diet. On the last day of taking NR, participants will return for repeat MRI/MRS scans, blood tests, and vital signs so that researchers can compare brain and blood measures before and after NR treatment. Researchers will compare each participant's brain NAD+ to NADH ratio and other bioenergetic markers before and after NR to see if NR changes these measures in a consistent way. If NR raises brain NAD+ and improves measures of energy metabolism in healthy adults, this may provide important background information for future studies that test whether NR can help people with psychiatric or neurological disorders linked to mitochondrial dysfunction and oxidative stress. There is no expected direct health benefit for participants, but their involvement may help improve understanding of how NR affects human brain metabolism.

ALDH2 Genetic Testing in East Asian Community

The goal of this clinical trial is to learn whether education plus genetic testing for ALDH2\*2 and ADH1B\*2 is feasible and acceptable and whether it influences modifiable health behaviors in East Asian American adults who experience alcohol flushing when they drink alcohol or have a family history of flushing. The main questions it aims to answer are: 1. Is providing education plus ALDH2\*2/ADH1B\*2 genetic testing feasible and acceptable in a clinical care context? 2. Does receiving genetic testing results plus education lead to changes in modifiable health behaviors compared with education alone? Researchers will compare education plus genetic testing (intervention arm) to education only (control arm) to see if adding genetic testing improves feasibility/acceptability and supports health behavior change. Participants will: 1. Complete an education module about alcohol flushing and ALDH2/ADH1B 2. Be randomized to either: (A) Receive genetic testing for ALDH2\*2 and ADH1B\*2 with results disclosure, or (B) Receive education only. 3. Complete follow-up measures about feasibility, acceptability, and modifiable health behaviors

Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 3

In Study 3, all tasks and models from Aim 1 will be evaluated in a large community sample of online participants recruited through Prolific. Aim 3 will establish 1) requirements for testing computational algorithms in population-based samples, 2) whether task length is optimal, and 3) whether computational parameters help predict psychopathology (hallucinations and delusions in particular) in the general population, and how these predictors may be impacted by demographic variables, such as race, ethnicity, gender, age and other social determinants of health. Participant demographics will be matched to the U.S. Census 2023 American Community Survey (ACS) data release (updated as available). MPI MacDonald has successfully recruited large online samples for over a decade. Specifically, researchers will recruit two samples of n=2,000 to preregister hypotheses and then n=3,000 to independently confirm those hypotheses. Multiple methods will affirm the highest quality human self-report and behavioral data for online samples. Researchers use Prolific, which is known for high quality research participation, maintaining low levels of bots through strategies such as requiring a photo ID and a waiting period. Second, inclusion criteria will require an approval rating of 90-100% from previous researchers. Participants will complete three sessions, each limited to \~60 min to avoid burnout.

Comparison Between Eccentric Hamstring Training and Sprint-Specific Training

The purpose of this study is to compare the effects of an intensity-, volume-, and time under tension-matched eccentric hamstring exercise intervention with the Romanian deadlift (RDL) and the Nordic hamstring exercise (NHE) to a sprint-specific training program on hamstring muscle architecture, volume, sprint performance, strength, and power. Participants will be assigned to complete one of the 3 hamstring interventions for 10 weeks.

A Single Ascending Dose Study of DTI-117 Given Intramuscularly in Healthy Participants.

This is a single ascending dose, double-blind, placebo-controlled, randomized evaluation of the safety, tolerability, and pharmacokinetics of DTI-117 in healthy volunteers. There will be up to five cohorts of 8 healthy participants each cohort.

Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2

In Study 2, investigators will recruit individuals with schizophrenia (SZ) and or schizoaffective disorder (SZA) and healthy controls (HC) using optimized behavioral tasks to replicate the behavioral findings from Study 1 and to assess additional psychometric properties such as test re-test reliability and practice effects. Investigators will obtain data on: A) clinical symptoms, with detailed assessment of hallucinations and delusions; B) community functioning; and C) functional capacity, allowing us to examine clinical validity. To generate a sample with sufficient variation in hallucinations and delusions, investigators will recruit the following groups that balance feasibility with clinical relevance: A) healthy controls \[HC, N=125\]; B) schizophrenia and schizoaffective disorder \[SZ/SZA, N=200\]). Investigators anticipate a \~20% screen fail/drop-out rate based upon prior studies. Thus, investigators will run an additional 40 SZ/SZA and 15 HC. Investigators will administer tasks optimized in Aim 1 without electroencephalogram (EEG), to this new sample of individuals with SZ/SZA and HC. All participants will be retested after approximately 28 days and repeat clinical assessments. Although the investigators' goal is to shorten task length using the Study 1 analyses, they will administer longer tasks than optimal for public dissemination in Study 2 to determine the minimum number of trials required for acceptable reliability. Study 2 will use the same clinical and functional measures as Study 1.

Modulation of Appetite Signaling Through Enterohormone Stimulation by DNF-10

This is a pilot, proof-of-concept, exploratory, randomized, double-blind, placebo-controlled crossover study. The study will be conducted in 50 healthy volunteers with a body mass index (BMI) between 18.5 and 29.9 kg/m². The objective is to comprehensively evaluate the potential of DNF-10 to modulate appetite through the regulation of enteroendocrine hormones and to determine its relevance in human physiology.

Cerebrospinal Fluid Kinetics of Urolithin A

The purpose of this study is to determine the impact of Mitopure® consumption on urolithin A (UA) kinetics in cerebral spinal fluid (CSF).

Trial in Healthy Volunteers to Evaluate 150 mg Subcutaneous CIT-013

This is a phase 1, double-blind, randomized, placebo-controlled, single center, repeat-dose trial for the assessment of safety, tolerability, bioavailability and pharmacokinetic profiles of 150 mg CIT-013 in healthy adult volunteers

Comparative Evaluation of the Anti-Plaque and Anti-Gingivitis Effects of Nanobiofusion Gingival Gel (NBF), Placebo Gel, and Commercial Toothpaste

The goal of this clinical trial is to learn if Nanibiofusion Gingival Gel (NBF) is able to reduce dental plaque and gum inflammation in adults. The trial will also check whether daily use of NBF Gingival Gel causes tooth staining over time. The main questions it aims to answer are: * Does NBF Gingival Gel reduce dental plaque (a sticky film of bacteria on teeth)? * Does NBF Gingival Gel reduce gum inflammation? * Does NBF Gingival Gel cause tooth staining? * Are participants satisfied with the product's taste, texture, and ease of use? Researchers will compare NBF gel to a placebo gel (a look-alike gel that contains no active ingredients), and Colgate toothpaste (a standard fluoride toothpaste). This will show if NBF gel is able to reduce plaque and gum inflammation. Participants will: * Be assigned to one of three groups and use their assigned product twice daily for 3 months. * Receive a professional teeth cleaning at the start of the study, before using any product. * Visit the clinic at baseline and at 1, 2, and 3 months for plaque, gum health, and staining checks. * Receive a complimentary professional cleaning at the final visit to remove any staining. * Rate the product's taste, texture, and ease of use.

Foam Roller Compared to Massage on Reducing Calf Muscle Tone in Healthy Subjects

Objective: This study aims to compare the effects of two techniques-foam rolling (FR) and therapeutic massage-on reducing the muscle tone in the calf muscles (gastrocnemius and soleus) of healthy individuals. Methods: A randomized, controlled crossover design was used with 40 healthy participants (aged 18-45). Participants were randomly assigned to either a foam roller or a therapeutic massage group. The interventions were applied to the dominant leg, and muscle tone was measured pre- and post-intervention using a MyotonPro device. The primary outcome was muscle tone (Hz), and secondary outcomes included muscle stiffness (N/m) and elasticity (D \[log\]). Results: The study will assess the effectiveness of each intervention on muscle tone, stiffness, and elasticity. It aims to determine whether foam rolling is as effective or superior to traditional massage in reducing calf muscle tone. Conclusion: This research will contribute to understanding the efficacy of foam rolling as a self-administered technique for muscle tone reduction and its potential application in clinical and athletic settings

AdHuman - Impact of Food Additives in Humans

Food additives, in particular hydrocolloids (thickening, gelling and stabilising agents), are widely used in the food supply. Concerns about carrageenan have led the food industry to replace it with alternative hydrocolloids, yet no one has compared these different commercial additives with respect to their effects on health. Experimental studies indicate that hydrocolloids can interact with the intestinal barrier, gut microbiota and immune signalling, with possible implications for both the gut-liver and gut-brain axes, but how they compare in humans is unknown. This study investigates how different food additives affect health in healthy adults. In an initial run-in period, all participants follow a standardised diet low in food additives to establish a common background diet. Participants are then randomised to receive foods containing different hydrocolloids - carrageenan and its commercial replacements - or a reference dietary fibre as comparator, on top of the shared background diet. The study examines effects on the liver, gut microbiota and short-chain fatty acid production, as well as measures relevant to the gut-brain axis such as mood, gastrointestinal symptoms and sleep. By providing the first controlled human comparison of carrageenan and its replacements, the study addresses a timely public health and regulatory question: whether the reformulation already adopted by the food industry has any measurable consequences for gut, liver and brain health.

Development of a Coffee Pulp Infusion as a Strategy for Recovery After Moderate Physical Exercise in a Healthy Population.

The goal of this clinical trial is to learn if a coffee pulp infusion works to improve muscle recovery after moderate physical exercise in a healthy adult population. It will also learn about its effects on oxidative stress and inflammation caused by exercise according to sex. The main questions it aims to answer are: * Does the coffee pulp infusion reduce the levels of oxidative stress, inflammation, and muscle damage markers after physical activity? * Are there differences between men and women regarding the response to the exercise and the benefits of the infusion? Researchers will compare the coffee pulp infusion to a placebo (a wheat bran infusion equalized in appearance and flavor but with low bioactive potential) to see if the coffee pulp infusion works to improve muscle recovery. Participants will: * Take the coffee pulp infusion or the placebo twice every day for 45 consecutive days. * Complete a total of 6 clinic and sports center appointments for physical tests, anthropometric records, and hemodynamic monitoring. * Perform a leg extension exercise protocol specifically calibrated to induce muscle stress and fatigue. * Provide capillary blood and morning urine samples at specific time points to measure biomarkers and metabolomic responses. * Complete several questionnaires regarding their sociodemographics, physical activity, dietary index, and perceived muscle soreness or effort.

Data-driven Rural Interventions for Vitality and Endurance Pilot Study

The study aims to explore whether data driven, personalized wellness interventions-based on integrated genomic, clinical, behavioral, and functional data- are feasible in a rural facing setting and can produce measurable improvements in cardiometabolic, cognitive, mental health, and functional wellness outcomes within four months. This study has three primary goals. 1. Identify scientific, behavioral, operational, and institutional learnings to inform future, larger-scale precision health research. 2. Explore how data from diverse rural populations can contribute to understanding diseases and resilience factors across environments. 3. Build frameworks for scalable community engagement, data collection, and feedback models.

Bioequivalence Study of Ferric Carboxymaltose Injection in Healthy Chinese Participants Under Fasting Conditions

The goal of this clinical trial is to compare the pharmacokinetic profile of the developed drug product and reference product in healthy participants under fasting condition. The main questions it aims to answer are: * \[Question 1\] Is there significant difference in the pharmacokinetic profile between the ferric carboxymaltose injection 750 mg iron/15 mL provided by Sichuan Huiyu Pharmaceutical Co., Ltd. and the ferric carboxymaltose injection licensed by American Regent, Inc. (trade name: Injectafer®, strength:750 mg iron/15 mL )? * \[Question 2\] Is it safe for healthy participants to take ferric carboxymaltose injection (750 mg iron/15 mL \[calculated by iron\]) provided by Sichuan Huiyu Pharmaceutical Co., Ltd. under fasting condition? Participants will be randomly divided into two groups by stratified blocked randomization, with equal number of healthy participants in each group, to receive test product or reference product according to the protocol below. * Dosing on D1: Group T (Test product) Group R (Reference product) * PK blood sample collection * Safety evaluation

Ivabradine for Heart Rate Reduction During Exercise in Healthy Adults

During exercise, working muscles require more oxygen. The heart meets this demand in two ways: by beating faster (heart rate) and by pumping more blood with each beat (stroke volume). Heart rate increases steadily with exercise intensity until exhaustion, but the amount of blood pumped with each beat tends to plateau at moderate intensities. Why the amount of blood pumped with each beat becomes limited before heart rate, however, is not well understood. Studying these mechanisms is difficult because most drugs that lower heart rate also affect how strongly the heart pumps, making it hard to separate the two effects. One medication that can help with this is ivabradine, which is used to treat people with heart disease who have high resting heart rates. It slows the heart rate without changing how strongly the heart pumps. This study will investigate whether ivabradine lowers heart rate during exercise in healthy younger and older adults, and whether a higher dose lowers heart rate more. The results will help us better understand how heart rate influences the heart's ability to supply oxygen to the body during exercise, and what limits the ability to exercise as people age. Participants will: * Attend three visits at SportsCardiologyBC in Vancouver * Complete a cycling exercise test at each visit to measure heart rate and how hard they can exercise * Take ivabradine (a heart-rate-lowering medication) before the exercise test at Visits 2 and 3 (a lower dose at Visit 2 and a higher dose at Visit 3) * Be monitored for side effects including slow heart rate, visual symptoms, and headache.

Effect of Systematic and Sequential Leg Elevation on Cardiac Output in Healthy Volunteers

Passive leg raising (PLR) transiently increases venous return and cardiac preload and is commonly used to predict fluid responsiveness in critically ill patients. Repeated fluid boluses contribute to fluid overload in septic shock, whereas PLR may provide similar hemodynamic effects without fluid administration. Before evaluating repeated PLR in septic shock patients, it is necessary to determine whether the cardiac output response to PLR remains present during repeated PLR maneuvers. SYSLE-1 is a prospective interventional physiological crossover study conducted in healthy volunteers. Participants will undergo six consecutive passive leg raising sessions performed either during spontaneous breathing or non-invasive ventilation, in randomized order. The study aims to determine whether the increase in cardiac output induced by the first PLR maneuver persists during repeated PLR sessions.

Dysfunction of Respiratory Enzymes in Adults With Mental Illness (DREAM)

This study tested whether intravenous methylene blue changes brain activity during a working-memory task differently in adults with schizophrenia taking stable antipsychotic medication and healthy volunteers. Each participant received methylene blue and a placebo solution with no methylene blue at separate visits and completed the task during functional magnetic resonance imaging (fMRI)

Testing of Personal Protective Equipment (PPE) for First Responders

The purpose of this pilot study is to improve protection of first responders in case of biological disasters (e.g., pandemics, biotoxin incidents). For this goal we will compare two different kinds of personal protective equipment (PPE) to be used for a variety of exercises simulating activities of first responders in the field at two different environmental temperature profiles in a randomized cross-over study design. The goal is to find the best possible compromise between protection and ergonomics as well as to determine potential factors that might limit the performance of first responders while wearing PPE. This should provide guidance for future improvement of PPE and how biosensors for monitoring heart rate and body temperature in combination with AI models may reduce risk for first responders in the field.

Pharmacokinetics and Safety of GH001 Delivered Via a GH001 Aerosol Delivery System in Healthy Subjects

The primary objectives of this trial are to determine the pharmacokinetic (PK) profile and the safety and tolerability of GH001 delivered via a proprietary aerosol delivery device in healthy subjects after single-dose administration.