Clinical Research Directory

Hyaluronic Acid Gel After Impacted Mandibular Third Molar Surgery

Surgical removal of impacted lower wisdom teeth can cause pain, facial swelling, difficulty opening the mouth, and discomfort during wound healing. This study evaluates whether placing a gel containing 0.2% hyaluronic acid into the tooth socket immediately after removal improves recovery compared with standard care alone. Adults requiring removal of similarly impacted lower wisdom teeth on both sides of the mouth undergo two separate operations at least 28 days apart. Each participant receives hyaluronic acid gel in one socket, while the other socket receives no additional material. Both sockets are closed with stitches. The order of surgery and the side receiving the gel are randomly assigned. Participants are not told which side receives the gel. Recovery is compared between the two sides of each participant. Pain and perceived swelling are recorded on days 1, 3, and 7 after each operation. Facial measurements and mouth opening are assessed before surgery and on days 3 and 7. Gum healing is assessed on days 3 and 7, and any complications are recorded. Participants receive the same routine postoperative care after both operations.

Preoperative Versus Postoperative Amoxicillin in Impacted Third Molar Surgery

This prospective observational cohort study evaluated the effects of the timing of amoxicillin use on postoperative recovery and oral health-related quality of life following impacted mandibular third molar surgery. A total of 52 healthy adults aged 18-50 years were included. Participants were classified into two cohorts according to the amoxicillin regimen selected by the treating clinician based on clinical assessment: preoperative amoxicillin, initiated 3 days before surgery and continued for a total of 5 days, or postoperative amoxicillin, initiated on the day of surgery and continued for 5 days. In both cohorts, amoxicillin was administered at a dose of 1000 mg twice daily. Postoperative pain, facial swelling, maximum mouth opening, and oral health-related quality of life were assessed. Pain, swelling, and mouth opening were evaluated on postoperative days 1, 3, and 7, and quality of life was assessed using the Oral Health Impact Profile-14 (OHIP-14) on postoperative day 7. The study aimed to compare postoperative recovery between the two antibiotic-timing approaches.

Effect of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Morbidity After Mandibular Third Molar Surgery

This randomized double-blind clinical trial aims to evaluate the effects of titanium-prepared platelet-rich fibrin (T-PRF), low-level laser therapy (LLLT), and their combination on postoperative outcomes following surgical extraction of impacted mandibular third molars. Sixty patients will be randomly allocated to one of four parallel groups: T-PRF, LLLT, T-PRF plus LLLT, or control. The primary outcomes include postoperative pain assessed using a visual analogue scale (VAS), analgesic consumption, postoperative swelling and trismus. The findings may help identify effective approaches for improving postoperative recovery after mandibular third molar surgery.

Comparison of PRF and Corticosteroids in Impacted Third Molar Surgery

This prospective, randomized interventional study aims to compare the postoperative effects of standard treatment (control), platelet-rich fibrin (PRF), and PRF combined with corticosteroid treatment in patients undergoing impacted mandibular third molar surgery. A total of 60 participants will be randomly assigned to one of three treatment groups according to the study protocol. Postoperative pain, facial swelling, and trismus will be evaluated on postoperative days 1, 2, 3, and 7. The findings of this study are expected to provide evidence regarding the effectiveness of PRF alone and PRF combined with corticosteroid treatment in reducing postoperative complications following impacted mandibular third molar surgery.

Effects of Preoperative Information Formats in Third Molar Surgery

This study evaluates whether physician-guided visual information provided before impacted mandibular third molar surgery can improve hemodynamic stability during the perioperative period. Participants are assigned to one of three preoperative information methods: standard verbal information, real surgical video information, or 3D animation video information. Changes in systolic blood pressure, diastolic blood pressure, heart rate, and oxygen saturation are assessed at multiple perioperative time points to determine whether visual information reduces stress-related physiologic responses. The study also examines whether these information methods influence preoperative dental fear.

Efficacy of Ozone Therapy in Reducing Complications Following Impacted Mandibular Third-molar Surgery

The goal of this clinical trial is to learn if use of ozone works to treat complications after impacted mandibular third molar surgery. It will also learn does ozone has positive effect on wound healing and quality of life. The main questions it aims to answer are: * Does ozone reduce incidence of postoperative compliactions such as pain, swelling or reduced mouth opening after impacted mandibular third molar surgery? * Does ozone improve wound healing after impacted mandibular third molar surgery? * Does ozone have positive effect on quality of life after impacted mandibular third molar surgery? Participants will: * Receive ozone after impacted mandibular third molar surgery. * Visit the clinic 1st, 3rd, and 7th days after the intervention for checkups and tests. * Keep a diary of their symptoms.

Evaluation of Corticosteroid Administration Following Impacted Third Molar Surgery Using 3-Dimensional Facial Analysis

The purpose of this prospective, randomized, controlled, single-blind clinical trial is to compare the efficacy of local submucosal administration of dexamethasone versus methylprednisolone on postoperative morbidity following impacted lower third molar surgery. The study evaluates postoperative pain using the Visual Analog Scale (VAS) and quantifies three-dimensional facial edema using a mobile smartphone-based scanning workflow (Qlone aligned in CloudCompare). Patients requiring unilateral extraction of fully bone-impacted mandibular third molars are randomly allocated into three parallel groups: Control (no injection), Methylprednisolone (40 mg), and Dexamethasone (8 mg).

Autologous Dentine Graft Compared to Xenograft in Managing Periodontally Compromised Second Molar After Third Molar Removal

The goal of this study is to evaluate the efficacy of autologous dentin graft (ADG) in treating periodontal defects on the distal aspect of mandibular 2nd molar (M2) after surgical removal of impacted mandibular 3rd molar (M3) by improving periodontal and radiological outcomes when compared with a xenograft, which is commercially available. The main questions it aims to answer are: 1. How does the clinical efficacy of ADG compare to xenografts, regarding wound healing and periodontal parameters at the distal aspect of periodontally compromised mandibular M2 following impacted M3 extraction? 2. How does the radiological bone regeneration at ADG-grafted sites differ from that at xenograft-grafted sites? 3. How do the post-operative patient-reported outcomes at sites receiving ADG differ from those at sites receiving xenografts? Researchers will compare ADG to xenograft to see if ADG is more efficacious in managing periodontal defects on distal aspect of M2 after surgical removal of M3. Participants will 1. Undergo bilateral surgical removal of M3 under general anaesthesia 2. Receive ADG on test site and xenograft on contralateral control site 3. Come back for clinical assessments, wound healing assessments and radiographic assessments for 5 times after the surgery (2 weeks, 1 month, 3 months, 6 months and 12 months)