Clinical Research Directory

Early Healing of Apical Periodontitis After Root Canal Treatment With Bioceramic and Calcium Hydroxide Medicaments: Evaluation Using PAI and ImageJ

This study aims to evaluate and compare early radiographic healing of apical periodontitis following root canal treatment using bioceramic and calcium hydroxide intracanal medicaments. Participants with apical periodontitis who meet the eligibility criteria will be assigned to one of two treatment groups. The first group will receive a bioceramic intracanal medicament (Bio-C Temp, Angelus), while the second group will receive calcium hydroxide (Ultracal, Ultradent). The assigned medicament will be placed inside the root canal for two weeks as part of the root canal treatment procedure. Periapical dental radiographs will be obtained at baseline and at the three-month follow-up using the paralleling technique. Radiographic images will be evaluated to assess changes in periapical healing over time. Periapical healing will be assessed using the Periapical Index (PAI) and quantitative image analysis with ImageJ software. The PAI will be used to evaluate the radiographic status of the periapical tissues. ImageJ will be used to measure the area and density of periapical lesions and their fractal dimension on periapical radiographs. The findings from the baseline and three-month follow-up assessments will be compared to evaluate changes in periapical lesions and to compare early radiographic healing between the bioceramic and calcium hydroxide groups. The study is expected to provide information on the effectiveness of bioceramic and calcium hydroxide intracanal medicaments in promoting early radiographic healing of apical periodontitis following root canal treatment.

Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments

This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis. Intracanal bacterial load is assessed before and after root canal preparation, after intracanal medicament removal, and after final irrigation using droplet digital PCR.

Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis

The objective of this study is to investigate "clinically" the effectiveness of Oleanolic acid based intracanal medicament compared to the commonly used intracanal medicaments (Calcium hydroxide and Ledermix) on the levels of bacteria in root canals and inflammatory cytokines in the periradicular tissues of teeth with apical periodontitis.