Clinical Research Directory

Intraperitoneal Lidocaine and Bupivacaine for Postoperative Pain After Laparoscopic Surgery

The goal of this clinical trial is to determine the safety and efficacy of combined intraperitoneal local anesthetic instillation and port-site infiltration using lidocaine and bupivacaine in adults aged 18 to 60 undergoing elective laparoscopic abdominal surgeries (such as laparoscopic cholecystectomy, appendectomy, or hernia repair). The main questions it aims to answer are: Does combined intraperitoneal local anesthetic instillation and port-site infiltration reduce immediate and early (up to 4 hours) postoperative pain scores? Does this intervention reduce the early need for additional postoperative analgesics and shorten the length of hospital stay? Researchers will compare the treatment group receiving lidocaine (2%) and bupivacaine (0.5%) by intraperitoneal instillation and port-site infiltration with a control group receiving normal saline by the corresponding routes to determine whether the local anesthetic intervention reduces postoperative pain and analgesic requirements. Participants will undergo scheduled elective laparoscopic abdominal surgery and receive either the local anesthetic intervention or normal saline during the surgical procedure. Pain will be assessed using the Visual Analog Scale (VAS) immediately after surgery in the recovery room and again at 2 and 4 hours after surgery. Analgesic needs will be monitored and documented, and total hospital stay will be recorded.

This Study Evaluate the Patient Response to Jet Injection, Pain and Satisfaction Compared to Conventional Method of Local Anasthesia Especially in Maxillary Teeth

Pain during administration of local anesthesia remains one of the major concerns in dental practice, often leading to anxiety and treatment avoidance. Conventional syringe infiltration, while effective, is associated with discomfort during needle insertion and injection. This study aimed to evaluate the effectiveness, patient comfort, and clinical applicability of jet injection as a needle-free alternative for maxillary tooth extractions. A total of 80 adult patients were enrolled from the College of Dentistry, University of Baghdad, and Al-Amiriya Specialized Center for Dentistry between December 2024 and March 2025. Jet injection with 2% lidocaine and 1:100,000 epinephrine was delivered buccally and palatally using the Comfort-In system, and patient responses were assessed through a visual analog scale and Likert-based subjective feedback.