Clinical Research Directory

Inhaled Lexofloxacin vs Usual Care for Treatment of Community-Acquired Pneumonia

This trial aims to determine whether treatment with inhaled levofloxacin (an antibiotic) is equal to systemic antibiotic treatment (usual care) for patients admitted to a hospital with community-acquired pneumonia in regards to treatment-effect and safety parameters. Additionally, this study will assess if treatment with inhaled antibiotics leads to fewer antibiotic side-effects and a more preserved gastro-intestinal microbial environment. The main question this study aims to answer is: Does inhaled levofloxacin 240mg twice daily result in comparable days alive and out of hospital at 14 days compared to standard-of-care (usual care) antibiotic treatment for community-acquired pneumonia in admitted patients? Secondary questions this study aims to answer are: 1. Does treatment with inhaled levofloxacin reduce proportion of patients with antibiotic side-effects? 2. Does treatment with inhaled levofloxacin lead to preserved diversity in the gut microbiome? 3. Is treatment with inhaled levofloxacin comparable with usual care in regards to patient reported outcomes? The above list is not the complete list of questions this study aims to answer, but serves as highlights.

Gut Microbiome Response to Long-Haul Travel in Elite Football Players

The goal of this randomised control trial is to measure the gut microbiome response to long-haul travel alongside the demands of pre-season amongst elite football players. The efficacy of a probiotic in modulating the gut microbiome to mitigate the detrimental impacts of long-haul travel as well as training in the heat will also be explored. The main questions this study aims to answer are: * How is the gut microbiome of the professional football player impacted by long-haul travel during the pre-season period? * How is immune function impacted by the demands of pre-season? * Can a probiotic dietary maintain gut microbial stability in response to long-haul travel? Researchers will compare the effects of the probiotic supplement with a placebo. Participants will be required to: * Provide a faecal sample at multiple points throughout the pre-season * Provide a saliva sample at multiple points throughout the season * Consume a daily supplement which will either be a placebo or probiotic capsule