Clinical Research Directory

The Efficacy of an IADL-based Non-immersive Virtual Reality Training Program to Enhance ADL Performance and Cognitive Function for Persons at Risk of Dementia

The goal of this clinical trial is to learn if a touchscreen-based virtual reality (VR) training program that simulates everyday life tasks works to improve daily living skills and thinking abilities in adults aged 50 and older, including those at risk of dementia (individuals with Subjective Cognitive Decline or Mild Cognitive Impairment). It will also explore what personal factors influence the training results. The main questions it aims to answer are: * Does the daily life VR training program improve participants' ability to perform complex everyday activities and adapt flexibly to daily life challenges? * Does the training improve overall thinking skills (such as memory, attention, and problem-solving), brain activity, and mood (depression and anxiety)? Researchers will compare the daily-life VR training program (IADL-VR) to a non-situational game VR program (Game-VR) and a traditional in-person tabletop cognitive training program (Cog-Entity) to see if realistic daily-life VR simulation works better to enhance everyday functioning and brain health. Participants will: * Be randomly assigned to one of the three training groups (daily-life VR tasks, digital brain-training mini-games, or traditional tabletop board games). * Attend a 2-hour group session once a week for 12 weeks, which includes 1 hour of assigned cognitive training and 1 hour of physical fitness exercise. * Complete assessments of their daily living skills, thinking abilities, mood, and brain activity (using functional magnetic resonance imaging, or fMRI) within 2 weeks before and after the 12-week program.

Clinical Cohort of Memory Disorders

This observational study is designed as a multicenter clinical cohort to collect and bank blood specimens linked to clinical and brain imaging data for biomarker discovery and validation in memory disorders. The protocol lists Severance Hospital, Gangnam Severance Hospital, and Yongin Severance Hospital as study sites. Planned enrollment is 1,550 participants: 1,500 adults aged 50 years or older and 50 healthy young adult controls aged 19-30 years. Participants are enrolled according to eligibility criteria and consent, irrespective of the specific medication received. Clinical information, cognitive assessments, and available brain magnetic resonance imaging (MRI) and positron emission tomography (PET) data will be collected to investigate diagnosis, disease severity, and clinical course. A total of 6 mL of research blood will be collected for banking, separated into plasma and buffy coat, and stored at -70°C. Young adult controls will provide a comparison for age-related and disease-related biomarker differences. The target follow-up duration for the memory disorder cohort is 5 years; young adult controls attend a single study visit. The overall study period is 120 months from IRB approval.