Clinical Research Directory

Comparison of the Need Of Mechanical Ventilation Between Less Invasive Surfactant Administration (LISA) and Conventional INSURE (Intubation-Surfactant Administration-Extubation) Methods in Spontaneously Breathing Preterm Infants With Respiratory Distress Syndrome

\*\*Brief Summary of the Study\*\* This randomized controlled trial aims to compare the need for mechanical ventilation between Less Invasive Surfactant Administration (LISA) and the conventional INSURE (Intubation, Surfactant Administration, and Extubation) method in spontaneously breathing preterm infants with respiratory distress syndrome. The study will be conducted in the Department of Neonatology, Sir Ganga Ram Hospital, Lahore, Pakistan, with a total sample size of 90 preterm infants born before 35 weeks of gestation. Participants will be allocated to either the LISA group or the INSURE group, with 45 infants in each group. The primary outcome will be the need for mechanical ventilation following surfactant administration, assessed within three hours of treatment. Data will be analyzed using SPSS version 25.0, with the chi-square test used to compare the need for mechanical ventilation between the two groups. The findings are expected to help identify the more effective surfactant administration method in reducing the need for mechanical ventilation in preterm infants with respiratory distress syndrome.