Clinical Research Directory

AI-Assisted Coronary Syndrome Subtyping From Admission History of Present Illness: A Clinician Reader Study

This study will evaluate whether an OCR-LLM-based clinical decision support framework improves clinicians' accuracy in classifying coronary syndrome subtypes from admission history of present illness. Participating clinicians will classify a set of cases first without AI assistance and then with assistance from the OCR-LLM framework. The primary outcome is the change in classification accuracy between unaided and AI-assisted assessments.

Optimal Timing of Microaxial Flow Pump(Impella CP) in AMI-related Cardiogenic Shock

PRIME-SHOCK is a prospective, single-center, open-label, randomized, superiority trial. Eligible participants with AMICS and a clinical decision to use Impella CP will be randomized in a 1:1 ratio before culprit-lesion PCI. The routine pre-PCI group will undergo Impella CP insertion immediately after allocation and before culprit-lesion PCI. The selective post-PCI group will undergo culprit-lesion PCI first; Impella CP will be inserted only if prespecified intra-procedural rescue criteria are met or shock persists or worsens after successful PCI. If all post-PCI recovery criteria are met, PCI will be concluded without Impella CP.

The Influence of Modifying Highly Calcified Coronary Lesions on Coronary Microcirculation

This is a prospective, single-center, three-arm study to evaluate the impact of severely calcified coronary lesions treatment on microvascular circulation. We will enroll 30 conveniently sampled subjects assigned to one of three therapeutical methods lithotripsy, super-high pressure balloon, and orbital atherectomy prior to implantation of drug-eluting stents (DES).