Clinical Research Directory

Effectiveness of a Music Therapy Intervention in Cancer Patients Undergoing Active Treatment at the Jaén University Hospital: a Non-randomized Controlled Trial.

A cancer diagnosis and its clinical progression can cause patients physical, psychological, emotional, social, and spiritual distress. This often requires the administration of active treatments, which are sometimes associated with spending long periods of time in the Medical Oncology Unit, resulting in a detrimental impact on their quality of life. A growing number of studies certify the benefits of music therapy, where the application of live music generates a change in the perception of the care management of the oncological process. We aim to create a climate of well-being in the Medical Oncology Day Hospital by hosting live music sessions during treatment administration. The objectives are: to analyze the effectiveness of a music therapy session in reducing stress in patients undergoing active cancer treatment, to analyze the effectiveness of a music therapy session in reducing anxiety symptoms in patients undergoing active cancer treatment, to analyze the effectiveness of a music therapy session in reducing depression symptoms in patients undergoing active cancer treatment, and to analyze the effectiveness of a music therapy session on the feeling of duration of the treatment session and in reducing treatment-related symptoms in patients undergoing active cancer treatment. A non-randomized controlled trial with two parallel arms with pre-post measurement will be conducted in patients with active intravenous cancer treatment received at the day hospital of the University Hospital of Jaén.

Reporting, Evaluating, Preventing and Treating the Cardiotoxicity Induced by Anticancer Drugs During a Specific Cardio-oncology Consult and Follow up in Routine Care

Several Drugs used in routine care in oncology induce rare but often severe or fatal cardiovascular or metabolic side effects. This study will investigate, evaluate, report and treat the cardiovascular side effects of anticancer drugs, through a specific cardiovascular routine checkup and follow-up taking place in several Cardio-oncology programs throughout France. The different including centers will be: Assistance Publique - Hôpitaux de Paris (APHP.6: Pitié-Salpétrière, Saint Antoine and Tenon's hospitals, Paris, France).

Integrative Oncology for Patient Symptoms

The use of complementary and integrative medicine (CIM) among oncology patients is widespread, with a large body of research-based evidence supporting the ability of these therapies to alleviate symptoms related to cancer and its treatment. Organizations such as the American Society for Clinical Oncology and the European Society for Medical Oncology have included CIM modalities in their treatment guidelines, and many of today's leading cancer centers include CIM in their supportive care service. The proposed study will prospectively examine the impact of a CIM treatment program on the symptom burden, quality of life and function of patients undergoing active oncology treatment. A total of 750 patients will undergo an integrative oncologist (IP) consultation followed by a series of 8 CIM treatments consisting of either acupuncture or touch-related therapies (reflexology, Shiatsu, Tuina, etc.) with the goal of relieving their symptoms. Patients will be allocated to one of the two study treatment arms: the "Patient-Preference Arm", for patients who specify their preference for either acupuncture or touch therapy; and the "Randomized Treatment Arm", for those with no preference, to be randomly allocated to either the acupuncture or touch-therapy subgroup. Patients will be asked to complete the following study questionnaires before and after the treatment regimen: the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30); the Edmonton Symptom Assessment System (ESAS); and the Measure Yourself Concerns and Wellbeing (MYCAW) tool. The primary study outcome will be the change in EORTC Global Health-Status / Quality of Life scores, from pre- to post-treatment. Secondary study outcomes will include EORTC QLQ-C30 functional and symptom scales, single items assessing additional symptoms commonly reported by cancer patients, and perceived financial impact of the disease; ESAS severity scores for 10 quality-of life related items; and MYCAW severity scores for the 2 most significant symptoms, as well as post-treatment narratives. Other secondary outcomes to be assessed include the safety of the study treatments (adverse effects); adherence to conventional treatment regimen; and narratives from the patient's informal caregiver (spouse, parent/child, sibling, friend, etc.).

The SaVe Project-Sarcopenia and Vertigo in Aging Patients With Colorectal Cancer

The goal of this clinical trial is to learn about the cause of dizziness and decline in walking ability in in older adults ≥65 years during chemotherapy treatment for colorectal cancer. Another goal is to investigate if a comprehensive geriatric assessment and three months' specialized physical group-based exercise three times/week can counteract muscle weakness, vertigo, instability, impaired walking balance, and neuropathy