Clinical Research Directory

IC ECG Combined With Ultrasound Bubble Test for PICC Tip Positioning Among Oncology Adults: A Three Arm Randomized Controlled Trial

The goal of this clinical trial is to learn if using IC-ECG together with ultrasound works better than either method alone to identify the tip position of a PICC in adults with cancer. It will also learn about the safety and efficiency of the combined method. The main questions it aims to answer are: Does the combined method confirm the correct PICC tip position more often than IC-ECG alone or ultrasound alone? Does the combined method find PICC malposition more accurately? Does the combined method take less time to complete tip positioning? What medical problems do participants have during or after the procedure? Researchers will compare three groups: IC-ECG alone, ultrasound alone, and IC-ECG plus ultrasound. A chest X-ray will be used as the standard check to see if the PICC tip is in the correct place. Participants will: Be adults with cancer who need a PICC. Be assigned by chance to one of the three groups. Have their PICC placed using the assigned tip-positioning method. Have a chest X-ray as the usual standard check. Allow the research team to record the procedure time, success, malposition, and any problems. Not pay for the IC-ECG or ultrasound tip-positioning tests used in the study. Chest X-ray is part of usual care and will be charged as usual. This study may help hospitals reduce routine X-ray use after PICC placement, lower radiation exposure, and make PICC placement safer and faster

Image-Guided Central Catheter Insertion With Concurrent Assessment of Vascular Wall Integrity

The insertion of peripherally inserted central catheters (PICCs) represents a minimally invasive and safe method for establishing long-term central venous access in patients requiring prolonged intravenous therapy, including chemotherapy, parenteral nutrition, and long-term antibiotic treatment. Ultrasound-guided cannulation of peripheral arm veins improves procedural success, reduces complications, and increases patient comfort compared with centrally inserted central catheters.Accurate positioning of the catheter tip at the cavo-atrial junction is essential for optimal catheter function and safety. The Sherlock 3CG Tip Confirmation System combines electromagnetic tracking with intracavitary electrocardiography (ECG) to enable real-time catheter tip navigation and positioning.The aim of this prospective clinical study is to evaluate the accuracy and safety of ultrasound-guided PICC insertion using the Sherlock 3CG system, as well as to assess the impact of PICC placement on venous wall integrity. Ultrasound examination of the target vein will be performed before catheter insertion and after catheter removal to evaluate potential vascular wall changes associated with catheter use. A chest X-ray examination will be performed after each catheter insertion to confirm final catheter tip position and to assess the accuracy of the navigation system.Fluoroscopic guidance will be used only in selected cases, such as patients with anatomical anomalies, previously known difficult vascular access, or unsuccessful standard catheter advancement.A total of 80 adult patients with a clinical indication for PICC placement will be enrolled over a three-year study period.

Effects of Different Tunnel Methods in PICC Catheterization

This prospective randomized controlled trial compares the effectiveness and safety of one-needle and two-needle tunneling techniques for peripherally inserted central catheter (PICC) placement, aiming to identify the optimal tunneling method to reduce catheter-related complications.

PICC Inserted by a Nurse-led Vascular Access Team in Poland

Implantation of PICCs by a trained, dedicated nursing team can be effective and safe, and allows for intravenous therapy that requires medium- to long-term central venous access.