Clinical Research Directory

Effort of Breathing and Dyssynchrony Burden During Assisted Ventilation in Paediatric Patients

The goal of this trial is to learn if one mode of mechanical ventilation (i.e. machine to help with breathing) is better than another in children who need help from a machine to breathe. The main questions it aims to answer are: * How hard do children need to work to breathe when they are using different types of modes of mechanical ventilation? * Evaluate which mode of mechanical ventilation performs better when the patient is clinically awake enough to start breaths

Children's Intensive Care Outcomes and Health Inequities: A Mixed Methods Study of Social Determinants in Paediatric Intensive Care in England

This mixed methods study aims to understand how factors such as ethnicity, deprivation, language, and access to healthcare affect outcomes for children admitted to paediatric intensive care (PICU). The main questions it aims to answer are: * Why are some children more likely to be admitted to paediatric intensive care, or to have worse outcomes once they are there, depending on their ethnicity or background? * At what points in a child's healthcare journey could earlier support or intervention make a difference? The first part of the study will involve interviewing parents and carers of children admitted to intensive care and health care professionals working in or referring children to intensive care. The second part of the study will be an analysis of existing NHS data. Participants will have an interview with a researcher lasting 45 minutes to an hour.