Clinical Research Directory

The Effect of Virtual Reality Headsets on Pain, Anxiety, Patient Satisfaction, and Physiological Parameters in Patients Undergoing Open-Heart Surgery

This randomized controlled trial aims to investigate the effects of virtual reality headset use on pain, anxiety, patient satisfaction, and physiological parameters in patients undergoing open-heart surgery. Participants will be randomly assigned to two groups: the virtual reality group and the control group. Pain levels, anxiety levels, satisfaction levels, and physiological parameters will be assessed both before and after the procedure. The study aims to determine whether this non-pharmacological method improves postoperative pain, anxiety, patient satisfaction, and physiological parameters.

A Comparison of Heart Rate Variability Biofeedback, Mindfulness, and Psychoeducation-based Interventions on Clinical Recovery Outcomes in Patients Undergoing Total Knee Arthroplasty

The goal of this clinical trial is to compare the effects of heart rate variability biofeedback (HRVB), mindfulness meditation, and psychological education in patients undergoing total knee arthroplasty (TKA). Patients waiting for TKA often experience anxiety, pain, and sleep problems before surgery. These factors may affect recovery after surgery. HRVB and mindfulness have been used to reduce stress and anxiety in different patient groups, but few studies have directly compared these approaches in patients undergoing TKA. The main questions this study aims to answer are: * Does HRVB improve postoperative recovery, including pain, sleep quality, quality of life, and knee function, compared with mindfulness meditation and psychological education? * Do HRVB and mindfulness meditation reduce preoperative anxiety more effectively than psychological education? * Are changes in heart rate variability and EEG measures related to recovery outcomes after surgery? Researchers will compare HRVB, mindfulness meditation, and psychological education to evaluate their effects on anxiety reduction and postoperative recovery. Participants will: * Be randomly assigned to one of three groups: HRVB, mindfulness meditation, or psychological education. * Receive one 15-minute intervention session before surgery. * Continue home-based practice during the first 2 weeks after surgery while following routine rehabilitation exercises. * Complete assessments before surgery and at 2, 6, and 12 weeks after surgery. The assessments will include measures of anxiety, pain, sleep quality, quality of life, knee function, heart rate variability, and EEG activity.

The Effect of Chewing Gum on Pain and State Anxiety During Intravenous Blood Sampling

This study was conducted to investigate the effect of chewing gum during intravenous blood sampling on pain and anxiety levels in individuals.

Efficacy of Pre-cooling and Sweet-tasting Solution on Pain Related to Local Anesthesia Injection in Children

The study aims to determine whether pre-cooling and sweet-tasting solutions, alone or combined with topical anesthesia, provide better pain control during dental local anesthesia in children. It has two phases: Phase 1: Identify the children's preferred sweet-tasting solution among xylitol, monk fruit, erythritol, and honey. Phase 2: A randomized controlled trial comparing 7 groups involving pre-cooling, sweet solution, topical anesthesia, and their combinations. The primary outcome is pain measured by VAS, while secondary outcomes include SEM behavioral response, heart rate, and oxygen saturation. The planned sample is 220 children.

the Objective of This Research is to Compare the Clinical Effectiveness of the Conventional Lingual Arch Space Maintainers With Three-dimensional Printed Space Maintainers.

the objective of this research is to compare the clinical effectiveness of the conventional lingual arch space maintainers with three-dimensional printed space maintainers.

Medical Effects of Proximal (In-person) Intercessory (PIP) and Virtual Intercessory Prayer (VIP) on Pain and Anxiety

This study examines whether proximal (in-person) intercessory prayer (PIP) and virtual intercessory prayer (VIP) can reduce pain and anxiety in adults seeking care at a family medicine clinic. Participants who report moderate or higher levels of pain or anxiety will be randomly assigned to receive either brief Christian prayer (in person or virtually) or a control condition of 5 minutes of relaxing music. Prayer sessions last approximately 5 to 15 minutes and are led by trained prayer practitioners. All participants complete surveys about their pain and anxiety levels before and after the session, and again at 2 to 4 weeks and 6 to 8 weeks. The goal is to determine whether prayer leads to greater improvement in pain and anxiety symptoms compared to the control condition, whether effects differ between in-person and virtual prayer, and how participants perceive the experience.

VR AI Meditation for Pain

This study aims to assess changes in pain and anxiety as reported by the Pain Numeric Rating Scale (PNRS) and the State-Trait Anxiety Inventory 6 (STAI-6), pre and post a guided meditation in Virtual reality. Objectives of the study are also to determine the feasibility, and patient acceptance of utilizing a LLM-generated guided meditation in VR. Our goal is to learn about any limitations of our approach and provide a pathway for future improvements in creating a VR AI therapist that is optimally aligned with the needs of users.

Virtual Reality in the Management of Painful or Anxiety-provoking Procedures in Emergency Departments

Study and evaluate the effectiveness of virtual reality in pain management.