Clinical Research Directory

Oral Immunotherapy for Children With Peanut Allergy

This clinical trial aims to investigate if oral immunotherapy can help children with peanut allergy tolerate peanut. Children aged 6 months to 4 years can take part in the trial. Main question: What percentage of children can tolerate peanut after oral immunotherapy, compared with children who avoid peanut? Children are assigned to these two groups by chance. Children receiving oral immunotherapy will: * Take a small, increasing amount of peanut daily for 1-1.5 years * Attend clinic or online visits each time the dose is increased * Record missed doses All children will: * Provide blood samples to measure allergy-related markers * Undergo an oral food challenge with peanut after 1-1.5 years to assess how much they can tolerate * Report allergic reactions (parent-reported) * Complete questionnaires (parent-reported) * Participate in an end-of-study telephone interview with an allergy nurse (parent-reported)