Clinical Research Directory

A Retrospective Cohort Study on the Non-Surgical Treatment of Periapical Inflammatory Lesions With Vitapex Paste

Background: Periapical inflammation is a common clinical condition, classified into periapical periodontitis, periapical granuloma, and periapical cyst. When the inflammatory mass is too large, root canal therapy alone is often insufficient to control the inflammation, and treatment typically requires a combination of surgical procedures. Studies have shown that delivering Vitapex paste through prepared root canals to the periapical inflammatory site can cause the inflammation to spontaneously subside or even resolve completely; however, there is currently limited research on this treatment approach. Objective: This study aims to treat apical inflammation using Vitapex paste, monitor changes in apical inflammation, determine the efficacy of Vitapex paste in treating periapical periodontitis, and provide a theoretical basis for this treatment method. Methods: This study employed a retrospective cohort design, and plans to enroll patients diagnosed with periapical inflammation and showing a distinct periapical shadow at the Department of Stomatology, Jinggangshan University Affiliated Hospital, between February 2025 and December 2027. Following conventional root canal preparation, Vitapex paste will be delivered to the site of periapical inflammation, and CBCT images will be collected at 6, 12, 18, and 24 months post-treatment to monitor changes in the volume of inflammation. Complete resolution of inflammation or a reduction in inflammation volume of more than 50% will be considered a success; a reduction of less than 50% will be considered a failure. If the success rate exceeds 80%, this will indicate that the use of Vitapex as a non-surgical treatment for controlling periapical inflammation is effective, thereby avoiding surgical intervention, minimizing patient trauma, and reducing treatment costs.

Evaluating The Use of CGF Plugs in Fresh Odontectomy Socket.

This study evaluates the use of Concentrated Growth Factor (CGF) plugs-a third-generation healing material made from the patient's own blood-to improve recovery after simple tooth extractions. CGF contains a dense matrix of growth factors and regenerative cells designed to enhance wound healing and tissue regeneration. Participants requiring a single, non-surgical tooth extraction will have a CGF plug placed into the empty socket immediately following the procedure. The researchers will then monitor two main factors: * Post-operative Pain: Patients will record their pain levels on a scale of 0 to 10 at 1, 3, and 7 days after the extraction. * Bone Density: Using specialized imaging (CBCT), the researchers will measure how well the bone heals and fills the socket immediately after the procedure and again at 3 months. The goal of this research is to determine if CGF plugs can effectively reduce patient discomfort and help preserve bone density, which is critical for future dental treatments like implants.

Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.

Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and antimicrobial characteristics. Because conventional medicaments can be expensive or have potential side effects, researchers are actively exploring natural options like garlic. Some lab studies have already shown that garlic gel can kill the microbes inside the teeth. However, no real-life clinical or X-ray studies have been done on using garlic in permanent teeth. This study may help scientists find a much safer and effective new material for dental treatments in the future.

Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication

Successful endodontic treatment and a predictable outcome can only be achieved by effective root canal debridement, irrigation, and elimination of microorganisms . The outcome of endodontic treatment performed in controlled clinical environment has demonstrated success rate around 90%. In certain cases, endodontic treatment may fail, one of the most common reasons is inability to eliminate microorganisms from the root canal. When non-surgical root canal therapy fails, the treatment options include orthograde re-treatment, periradicular surgery, or extraction. Simvastatin (SIM) is a drug used primarily to treat hyperlipidemia and protect against cardiovascular diseases. It has been shown to possess pleiotropic effects such as antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and bone-forming properties . The side chain of this material has a single methyl group. It inhibits hydroxymethyl glutarylcoenzyme reductase that prevents endogenous cholesterol synthesis