Clinical Research Directory

Clinical Research on Deep-Plane Rejuran S Injection for Improvement in the Apperance of Periorbital Hollowing Using a Cannula Technique

The goal of this clinical study is to learn whether DOT PN (Rejuran S), a polynucleotide injectable gel, improves periorbital hollowing (a sunken look around the eyes) in adults aged 25 to 65 years when injected into the deep layer around the eyes with a blunt cannula. Safety will also be assessed. The main question it aims to answer is: \- How much do tear trough depth and brow height change from baseline to Week 16, as measured by 3D imaging? There is no comparison group. All participants receive the study treatment. Participants will: * Receive injections around both eyes (4.0 mL in total per visit) at Weeks 0, 4, 8, and 12 * Have 3D facial photographs taken and report side effects at each visit * Return for follow-up visits at Weeks 16, 20, and 24.