Clinical Research Directory

Impact of Optimized White Light on Visual Discomfort, Headache Intensity, and Cognitive Performance Among Those With Migraine

The goal of this research is to study how effective an optimized white light is for improving visual comfort and reducing migraine symptoms. To do so, we will compare the effects of an optimized white light with those of a standard, commercially available white light. The main study objectives are to: 1. Compare the effects of an optimized white light spectrum vs. a conventional white light on visual discomfort levels in people with and without migraine. 2. Evaluate the effects of each lighting condition on headache intensity, cognitive performance, and pupil size. This study will inform the design of more comfortable lighting environments for individuals with migraine. The implementation of optimized white light in healthcare settings, offices, schools, and homes may serve as a practical strategy to improve comfort and reduce symptoms for those with migraine.

Objectively Diagnose and Monitor Treatment of Light Sensitivity

The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.

Use of Tinted Contact Lenses for Concussion-Related Light Sensitivity

The purpose of this study is to gather pilot data on the effectiveness of daily disposable tinted contact lenses in reducing photophobia (light sensitivity) following a concussion, with the goal of facilitating the return to work or school.

Comparison Between Spectacles and Contact Lenses

Many people suffer from migraine headaches, some more so than others and a common trigger/complaint is light sensitivity, or photophobia1. Some will go to great lengths to avoid light: a dark room with sunglasses on and blankets over the windows, often missing work/school/social activities, etc. Several ocular conditions are accompanied by photophobia, ranging from mild to debilitating.

Light Exposure, Migraine Outcomes, and Sleep Quality

The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period.

Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in Veterans with a history of mild traumatic brain injury (mTBI). The study will also complete resting-state MRI scans to assess neurophysiological markers of photosensitivity and changes associated with LIP-tES intervention.