Clinical Research Directory

Efficacy of Thymus Vulgaris Mouthwash in the Management of Biofilm-Induced Gingivitis

The goal of this clinical trial is to determine whether a mouthwash made from thyme (Thymus vulgaris) helps improve gum health in people with plaque-induced gingivitis. The mouthwash will be compared with chlorhexidine mouthwash and a placebo (a mouthwash without the active ingredient being tested). The main questions this study aims to answer are: Does Thymus vulgaris mouthwash improve gum health and reduce plaque accumulation and gingival bleeding? Does it change salivary levels of substances associated with gum inflammation and tissue damage? What side effects do participants experience, and how do they rate their experience with the mouthwash? Participants will be randomly assigned to one of three groups: 0.2% Thymus vulgaris mouthwash, 0.12% chlorhexidine mouthwash, or placebo. They will: Rinse with 10 mL of their assigned mouthwash twice daily for 1 minute per use. Have their gum health assessed at the beginning of the study, after 2 weeks, and after 1 month. Provide saliva samples at each visit for laboratory testing. Report any side effects and share their experience with the assigned mouthwash. To help ensure a fair comparison, the mouthwashes will be provided in identical containers with coded labels. Neither the participants nor the examiner will know which mouthwash each participant receives until the study is completed and the group codes are revealed according to the study's blinding procedures.

Individualized Management of Plaque-Related Gingival Inflammation in Routine Dental Practice

Gingival inflammation is common and can often be reversed with effective daily oral hygiene. However, preventive care is not always delivered consistently in dental practices, and patients may not receive sufficient individualized training in oral self care and follow-up support. This study will evaluate whether a structured preventive care workflow, called iMGi (individualized management of gingival inflammation), can be implemented consistently in routine dental practice. Approximately 100 adults with plaque-related gingival inflammation will participate across multiple clinical centres. All participants will receive structured preventive care, including assessment of gingival health, individualized oral self-care training, professional preventive care, and follow-up appointments over approximately 10 months. The main aim is to understand whether the workflow is practical for dental professionals to deliver, acceptable to patients and practitioners, and consistently applied across different clinical settings. The researchers will also collect information on gingival bleeding, oral hygiene, patient experiences, and oral self-care behaviour to explore changes during the study. The findings may help improve how preventive oral healthcare is organized and delivered in everyday dental practice.

Clinical Outcomes of Different Mouth Rinses During Clear Aligner Orthodontic Therapy

This pilot randomized controlled clinical trial will evaluate the feasibility and preliminary clinical effects of three mouth rinses-alum, Triphala-based herbal mouth rinse, and 0.2% chlorhexidine-in adults undergoing clear aligner orthodontic treatment. Clear aligners and bonded attachments may contribute to plaque accumulation and gingival inflammation. Mouth rinses may provide an additional measure for controlling plaque and gingival inflammation during orthodontic treatment. Chlorhexidine is a commonly used antimicrobial mouth rinse, while alum and Triphala are being evaluated as alternative agents. A total of 30 adults aged 18-35 years undergoing active clear aligner therapy and presenting with mild to moderate plaque-induced gingivitis will be randomly assigned in equal numbers to one of three groups. Participants will use their assigned mouth rinse twice daily for 30 days. Gingival inflammation will be assessed using the Gingival Index, and plaque accumulation will be assessed using the Plaque Index at baseline, 15 days, and 30 days. Salivary Streptococcus mutans levels will also be assessed. Compliance with mouth-rinse use and other feasibility measures, including recruitment and retention, will be recorded. The study is intended as a pilot trial to assess feasibility, estimate variability and preliminary treatment effects, and provide information for the design of a future adequately powered clinical trial.

Pain Perception After Manual and Ultrasonic Periodontal Debridement in Patients With Gingivitis

This study compared immediate pain perception following manual and ultrasonic supragingival periodontal debridement in patients with plaque-induced gingivitis. It also evaluated whether dental anxiety, pain catastrophizing, and general pain sensitivity were associated with pain experienced during periodontal instrumentation. Participants underwent either manual supragingival debridement using hand instruments or ultrasonic supragingival debridement. Before treatment, dental anxiety, pain catastrophizing, and pain sensitivity were assessed using validated questionnaires. Immediately after the procedure, participants rated their pain intensity using a visual analog scale (VAS). The study aimed to determine whether immediate pain perception differed between the two instrumentation methods and to examine the contribution of individual psychological and pain-related characteristics to perceived pain.

Impact of Oral Hygiene Instruction in Gingivitis Patients

The aim of this study is to comparatively evaluate the effectiveness of two different oral hygiene instruction methods given in addition to Phase 1 periodontal treatment in patients diagnosed with gingivitis, on periodontal clinical parameters and patient awareness scores, and to examine the relationship between the change in awareness score and clinical improvement. The main question it aims to answer is: Is video-based visual oral hygiene training as memorable and motivating as hands-on training using a model? A total of 80 patients who were diagnosed with gingivitis were included in the study. The oral health of the patients was assessed by a researcher using periodontal indices, and patients were asked to complete a 10-question questionnaire to assess their own periodontal health and oral hygiene status (T0). Following baseline measurements, all patients received standard Phase 1 periodontal treatment by another clinician. At the end of treatment, patients were randomly assigned to two different oral hygiene instruction (OHI) groups of 40 each: Group 1 (Video Group): Oral hygiene instruction in this group was provided through standard video content; Group 2 (Model Group): Oral hygiene instruction was given through practical demonstration using three-dimensional dental models. Patients were called for a follow-up appointment one month after the Phase 1 periodontal treatment (T1). All initial clinical indices were measured and recorded, and patients were asked to complete the same awareness questionnaire again.

Innovative Mouthwash in School-Aged Children With Fixed Orthodontic Appliances

Fixed metal orthodontic appliances create additional plaque-retentive areas around brackets, archwires and ligatures, making mechanical plaque control more difficult in children and adolescents. Increased plaque accumulation may contribute to gingival inflammation, bleeding, halitosis and early enamel changes. Therefore, adjunctive preventive agents, including mouthwashes, may be clinically useful as part of a comprehensive oral hygiene program during fixed orthodontic treatment. The aim of the study is to evaluate the clinical effectiveness and tolerability of a test mouthwash in children and adolescents with fixed orthodontic appliances by monitoring plaque accumulation, gingival inflammation, gingival bleeding and halitosis.