Clinical Research Directory

Scavenging of Reactive Carbonyl Species by Blueberries in Humans

This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of blueberry polyphenols in humans after a single dose of dietary flavonoids.

Scavenging of Reactive Carbonyl Species by Soymilk in Humans

This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of soymilk polyphenols in humans after a single dose of dietary flavonoids.

Effects of Polyphenols on Iron Absorption in Iron Overload Disorders.

Dysmetabolic iron overload syndrome and genetic hemochromatosis are frequent causes of iron overload. Polyphenols are efficient iron-chelators. Investigator hypothesize that polyphenol supplementation can reduce iron absorption in iron overload disease. Iron absorption can be studied by the area-under-the-curve of serum iron after iron oral loading. The primary outcome is the decrease of post-prandial serum iron after rich-iron meal, due to polyphenol supplementation.

Scavenging of Reactive Carbonyl Species by Apple Polyphenols in Human

This is an interventional study to investigate formation and pharmacokinetics of reactive carbonyl species adducts of apple polyphenols in human after a single dose of apple consumption.

Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans

This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of dietary polyphenols (soymilk, green tea, and blueberry) in humans after a single dose of dietary flavonoids.

a Polyphenol Whole Tumor Cell Vaccine in Patients With Advanced Malignant Solid Tumors

This project intends to carry out phase I clinical studies on the basis of the previous work, initially exploring the possible effective dose, evaluating its safety and tolerability, with a view to achieving long-term control of the disease, which is expected to provide more options for the treatment of patients with advanced malignant solid tumors. The development of this project will provide new ideas, strategies and theoretical basis for the research and development of whole tumor cell vaccines; at the same time, it is expected to obtain original new drugs with independent intellectual property rights.