Clinical Research Directory

Effect of Resistance Training on Ventilatory Function, Respiratory Muscle Strength, and Quality of Life in Postmenopausal Women

Investigating the effects of adding resistance training to breathing exercises, compared with breathing exercises alone, on ventilatory function as the primary outcome and respiratory muscle strength, functional capacity, and quality of life as secondary outcomes in postmenopausal women.

Exercise Intervention in Preventing Breast Cancer Recurrence in Postmenopausal Breast Cancer Survivors

This randomized pilot trial studies how well an exercise intervention works in preventing breast cancer from coming back in postmenopausal breast cancer survivors. Regular exercise may be able to train the body to repair deoxyribonucleic acid (DNA) more efficiently and to respond to inflammation more proficiently, helping to prevent primary and recurrent breast cancer.

Alisertib With or Without Fulvestrant in Treating Patients With Locally Advanced or Metastatic, Endocrine-Resistant Breast Cancer

This phase II trial studies how well alisertib with or without fulvestrant works in treating patients with endocrine-resistant breast cancer that has spread to other places in the body. Alisertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hormone therapy using fulvestrant may fight breast cancer by blocking the use of estrogen by the tumor cells or reducing the amount of estrogen made by the body. Giving alisertib with or without fulvestrant may be better in treating patients with breast cancer.

Cyclic vs. Constant Estradiol: Regimens' Effects on Brain Health

The purpose of this study is to learn more about how estradiol patch treatment affects brain processes, health, and wellbeing.

Effect of Postural Correction Exercises on Pelvic Floor Dysfunction in Postmenopausal Osteoporotic Women

This study aimed to investigate the effect of postural correction exercises on pelvic floor dysfunction in postmenopausal osteoporotic women

Oxytocin in Postmenopausal Women

The aim of the present study is to assess whether cumulative endogenous neurophysin I secretion over one month differs between premenopausal and postmenopausal women. Using repeated measurements of neurophysin-I (NP-I, equimolar surrogate marker of oxytocin) across defined physiological time points, this study investigates oxytocin system regulation under cyclic and non-cyclic hormonal conditions. The primary hypothesis is that cumulative NP-I release, expressed as the area under the curve (AUC) is lower in the postmenopausal group compared to the premenopausal group.

Tai Chi for Reducing Aromatase Inhibitor-Induced Arthralgia

The objective of the pilot RCT is to evaluate the feasibility and acceptability of a Tai Chi intervention "TaiChi4Joint" vs. an HE AC group for relieving AIIA in women with hormone receptor positive stage I-III BCa. The investigators will pilot test our data collection for mechanism measures via three innovatively integrated biobehavioral pathways.

Short-term Circuit Training on Muscle Mass and Quality of Life in Sedentary Postmenopausal Women

The purpose of this graduate student research study is to provide healthcare professionals with evidence of the potential of circuit strength training in improving the physical and psychosocial well-being of postmenopausal women.

Bupropion Hydrochloride in Improving Sexual Desire in Women With Breast or Gynecologic Cancer

This phase II randomized trial studies how well bupropion hydrochloride works in improving sexual desire in women with breast or gynecological cancer. Bupropion hydrochloride may work by boosting sexual desire, energy, or motivation without causing intolerable or undesirable side effects.

Cardiometabolic Adaptations to Concurrent Training: Effect of Effort Configuration on Postmenopausal Women

The main objectives of this project are to assess the effects of a 20-week concurrent training program on neuromuscular adaptations, body composition, cardiometabolic health, quality of life, mood state, physical self-perception, and menopause-related symptoms in physically active postmenopausal women, and to compare the adaptations resulting from different combinations of endurance and resistance training programs with varying effort configurations. Additionally, this project aims to examine the longitudinal interaction and potential interference effects between endurance and resistance training effort configurations throughout the training program and to determine the optimal combination of effort configurations that maximizes health benefits in concurrent training programs for physically active postmenopausal women.

Structured Combined Exercise Program in Postmenopausal Women: Effects on Heart Rate Variability and Menopausal Symptoms

The goal of this clinical trial is to learn whether a structured combined exercise program can improve heart health, menopausal symptoms, sleep quality, and quality of life in postmenopausal women aged 45 to 65 years. The main questions it aims to answer are: Does the exercise program improve heart rate variability, which shows how well the heart is controlled by the nervous system? Does the exercise program lower menopausal symptoms? Does the exercise program improve sleep quality and quality of life? Researchers will compare women who join the exercise program with women who continue their usual daily activities. Participants in the exercise group will take part in a supervised exercise program for 12 weeks. They will exercise 2 days each week. Each session will last 45 minutes and will include warm-up, balance, strengthening, coordination, flexibility, and cool-down exercises. Participants in the control group will continue their usual daily activities during the study.

Cardiovascular Adaptations to Resistance Exercise: Effect of Set Configuration on Postmenopausal Women

The main purpose of this project is to analyze the effect of set configuration of resistance exercise on cardiovascular responses and adaptations of postmenopausal women. Additionally, since previous studies have shown that individual´s blood pressure level can influence on the impact of resistance training programs on cardiovascular changes, we aim to contrast acute and chronic changes to resistance training programs in normotensive and hypertensive postmenopausal women.

Smart Technology-Based Intervention and Monitoring of Physical and Mental Health in Early Postmenopausal Women

The aim of this study is to compare the short-term and long-term effects of an 8-week home-based multimodal exercise program, delivered through a smartphone app, on quality of life, muscle function, and physical performance in early postmenopausal women.

Exercise, Insulin Resistance, and Chronic Pain in Postmenopausal Women.

This study aims to investigate the effects of a combined exercise program on chronic pain in postmenopausal women, considering insulin resistance as a potential physiological mediator. The intervention will assess changes in pain intensity, metabolic and inflammatory biomarkers, psychosocial factors, and body composition. The findings may contribute to understanding the metabolic mechanisms underlying chronic pain in postmenopausal women and support exercise as a non-pharmacological therapeutic strategy.

Spousal Support and Sexual Quality of Life in Postmenopausal Women

Menopause is a natural transition period in women's lives characterized by concurrent hormonal, psychological, and relational changes. During the postmenopausal period, hormonal alterations are not limited to physical symptoms but also have significant effects on psychological well-being, interpersonal relationships, and particularly sexual quality of life. Common concerns during this period include decreased sexual desire, vaginal dryness, pelvic discomfort, and reduced sexual satisfaction, all of which may negatively affect overall quality of life. Sexual quality of life is influenced not only by biological factors but also by psychological and relational dimensions. The quality of partner relationships and perceived partner support play an important role in women's adaptation to sexual changes during the postmenopausal period. However, partner support during menopause is often reported to be insufficient, which may adversely affect sexual well-being. Despite this, evidence examining the relationship between perceived partner support and sexual quality of life in postmenopausal women remains limited. The aim of this study is to examine the effect of perceived partner support on sexual quality of life in postmenopausal women. Through this investigation, the explanatory role of partner support in postmenopausal sexual well-being is aimed.

Effects of Multiple Intervention on Postmenopausal Women With UI

Study The purpose of this clinical trial was to investigate the effects of a multi-intervention approach, including Kegel and Tai Chi exercises, on quality of life, self-efficacy, and urinary incontinence severity in postmenopausal women. Key Questions the Study Aims to Answer: How does the multi-intervention approach affect quality of life? Does the multi-intervention approach affect women's self-efficacy? How does the multi-intervention approach affect urinary incontinence severity? How does the frequency of exercises (3 days per week vs. 6 days per week) affect these outcomes? Do the effects of the intervention change temporally over the 8-week period? Who is Eligible? Women aged 45 and over who have gone through menopause Those who wish to volunteer for the study Those who have no communication barriers Those who have not previously received treatment for urinary incontinence Those who can use a smartphone or WhatsApp Those who experience urine leakage when coughing or sneezing Study Application: The exercises will be administered for 8 weeks. Participants will be taught how to perform the exercises and will be demonstrated through brochures and videos. Reminders will be provided during the exercises.

Water Based Burpee Exercises on Functional Capacity in Poste-menopausal Women After Thyroidectomy

Skeletal muscle mass plays an important role with both metabolism and functional capacity. It is well established that the aging process leads to a significant decline in both muscle mass and strength which is associated with frailty , an increased risk of falls and decreased physical fitness and function In this context, high-load resistance training has been shown to reduce the risk of falls and increase strength and functional capacity in middle-aged and/or elderly individuals. Aquatic exercise is one method that has previously been shown to improve muscle strength, balance, and coordination in those of advancing age Although the evidence supports the effectiveness of both water-based burpee exercise in middle-aged and elderly individuals, has, to our knowledge, never been investigated. Thus, the objective of this study was to assess the long-term effect of water-based burpee exercises

Protein and Exercise for Postmenopausal Women's Wellbeing

The goal of this clinical trial is to learn if consuming a higher protein diet that includes one serving of beef each day, in combination with resistance exercise, improves wellbeing in postmenopausal women. It will also tell us about how higher protein intake changes body composition and blood values related to health. The main questions it aims to answer are: * Does higher protein intake combined with resistance training improve mood and sleep in postmenopausal women? * What other health benefits to postmenopausal women experience when the follow a higher protein diet and participate in resistance exercise? Researchers will compare three groups 1) postmenopausal women living their daily lives as usual, 2) postmenopausal women consuming a higher protein diet, and 2) postmenopausal women consuming a higher protein diet and participating in resistance training. Participants will: * Consume a higher protein diet for 16 weeks * Participate in an at-home resistance training for 16 weeks * Keep a diary of their food intake, sleep habits, and mood * Have health assessments every 4 weeks

Influence of Iyengar Yoga on the Bio-functional Age of Postmenopausal Women

The purpose of this Study is to find out if Iyengar-Yoga has a rejuvenating effect on women after menopause. The biofunctional status of the study participants will be assessed before and after a 12-week yoga program.

Breathing Exercises on Depression in Postmenopausal Women

Evaluate the effect of breathing exercises on depression and sexual function in postmenopausal women

Comparative Effects Of Dynamic And Static Stretching In Postmenopausal Females With Knee Osteoarthritis

As the aging population continues to grow, there is a pressing need to explore effective interventions to alleviate the symptoms of osteoarthritis, particularly in postmenopausal women who may experience unique challenges. Osteoarthritis (OA) is progressive joint disease characterized by joint inflammation and a reparative bone response and is one of the top five most disabling conditions that affects more than one-third of persons \>65 years of age, commonly affecting hands, feet, spine, hips, and knees. Among the various therapeutic modalities, stretching exercises, both dynamic and static, have gained attention for their potential to enhance joint flexibility, reduce pain, and improve functional outcomes.