Clinical Research Directory

Oral Bromelain After Bilateral Mandibular Third Molar Surgery

The goal of this clinical trial is to learn whether oral bromelain, a pineapple-derived enzyme supplement, reduces facial swelling, limited mouth opening (trismus), and pain after surgical removal of impacted lower wisdom teeth in healthy young adults. The main questions it aims to answer are: * Does adding bromelain to standard postoperative medication reduce facial swelling and trismus? * Does it reduce postoperative pain and the number of painkillers taken? Researchers compared each patient's recovery after two separate operations: one followed by standard medication alone and one followed by standard medication plus bromelain. Participants: * Had both impacted lower wisdom teeth removed in two separate sessions about two weeks apart * Took bromelain (500 mg twice daily for 5 days) after one randomly selected session * Had facial swelling and mouth opening measured before surgery and on days 2 and 7 * Rated their pain at set times during the first week and recorded the painkillers they took

COMFORT Trial: Complex Obstetric Management With Focused Regional Transversus Abdominis Plane Block

To assess the effect of intraoperative transversus abdominis plane (TAP) blocks on the amount of opioid pain medications expressed as morphine milliequivalents (MME) used postoperatively in patients who have undergone cesarean delivery (CD) in the setting of complex obstetric surgery (COS).

Intertransverse Process Block Versus Erector Spinae Plane Block for Pain Relief in Lumbar Spine Surgery

The goal of this clinical trial is to learn whether two types of ultrasound-guided nerve block, the intertransverse process block and the erector spinae plane block, reduce pain and the need for opioid pain medicines during and after lumbar spine surgery in adults. It also compares the two blocks with each other. The main questions it aims to answer are: Do patients who receive either nerve block need less morphine in the first 24 hours after surgery than patients who receive only local anesthetic injected at the skin incision? Is there a difference between the two nerve blocks in pain scores, the amount of opioid medicine needed during and after surgery, the time until patients first ask for pain medicine, and side effects? Researchers will compare three groups: an erector spinae plane block group, an intertransverse process block group, and a control group that receives local anesthetic infiltration at the incision site. Participants will: Be randomly assigned to one of the three groups before surgery Receive the nerve block on both sides of the spine with ropivacaine before general anesthesia (block groups), or local anesthetic infiltration along the planned incision after induction of anesthesia (control group) Undergo general anesthesia and lumbar spine surgery following the same standard protocol Use a patient-controlled analgesia pump that delivers morphine on demand for 24 hours after surgery Rate their pain at rest and during movement at set times over the first 24 hours, and be monitored for side effects such as nausea and vomiting

Serratus Anterior Plane Block for Recovery After Minimally Invasive CABG

Coronary artery bypass surgery is an important treatment method for severe coronary heart disease. Among them, minimally invasive bypass surgery, although having less trauma, requires a small incision on the left chest. During the operation, the ribs need to be opened and the muscles of the chest wall pulled, which is prone to causing intercostal nerve damage. Therefore, many patients still experience severe incision pain and chest wall pain after the surgery. This study adopted the "Serratus Anterior Plane Block", which is a regional anesthesia technique. The doctor will inject the anesthetic drug into the gap near the pectoralis major muscle (a muscle located on the side of the chest) under ultrasound guidance. This technique can effectively block the nerves that transmit pain signals, thereby providing good analgesic effects for the anterior lateral chest wall and helping patients alleviate postoperative pain.

Ultrasound-guided TAP Block Vs Local Wound Infiltration for Analgesia After Cesarean Section.

Adequate pain control after cesarean delivery is a major concern for both parturients and obstetrician, and it usually comprise a combination of systemic and regional techniques. The transversus abdominis plane (TAP) block, affecting the nerves supplying the anterior abdominal wall, is a recently introduced, promising regional analgesic technique for a variety of abdominal and pelvic surgeries including cesarean delivery . Infiltration of local anesthetic into the surgical wound (either as a single shot or using indwelling catheters) has long been used for postoperative analgesia, Both the TAP block and wound infiltration, are superior to placebo, however, it is unknown which of them provides better analgesia after cesarean delivery because of a scarcity of randomized clinical trials. This study aimed to compare bilateral US guidedTAP block with single-shot local anesthetic wound infiltration for analgesia after cesarean delivery performed under general anesthesia. The investigators hypothesized that the TAP block would decrease postoperative cumulative opioid consumption at 24 hours.

Evaluation of Corticosteroid Administration Following Impacted Third Molar Surgery Using 3-Dimensional Facial Analysis

The purpose of this prospective, randomized, controlled, single-blind clinical trial is to compare the efficacy of local submucosal administration of dexamethasone versus methylprednisolone on postoperative morbidity following impacted lower third molar surgery. The study evaluates postoperative pain using the Visual Analog Scale (VAS) and quantifies three-dimensional facial edema using a mobile smartphone-based scanning workflow (Qlone aligned in CloudCompare). Patients requiring unilateral extraction of fully bone-impacted mandibular third molars are randomly allocated into three parallel groups: Control (no injection), Methylprednisolone (40 mg), and Dexamethasone (8 mg).

An Efficacy and Safety Study of LTG-001 Following Abdominoplasty

The goal of this clinical trial is to learn if LTG-001 works to treat post-operative / acute pain after an abdominoplasty procedure. It will also learn more information on the safety of LTG-001. The main questions it aims to answer are: Does drug LTG-001 treat the acute pain after surgical abdominoplasty over 48 hours? How tolerable is LTG-001 over 48 hours? What dose of LTG-001 is better for treating post-operative / acute pain? Participants will: Take LTG-001 bid after the surgical abdominoplasty. Remain at the clinic for approximately 48 hours during study dosing and return after two weeks for a safety check up. Report the pain relief during the 48 hours to record changes in the post-operative pain.