Clinical Research Directory

Intermittent Fasting Versus Carbohydrate Drinks Before Surgery

The purpose of this study is to investigate whether time-restricted feeding, a form of intermittent fasting, before surgery improves insulin resistance around the time of surgery, compared to carbohydrate drinks and standard fasting before surgery.

Preoperative Fasting and Perioperative Outcomes in Children Undergoing Elective Circumcision

This prospective observational study aims to evaluate adherence to preoperative fasting guidelines and investigate the relationship between actual fasting durations, anxiety levels, and blood glucose levels in children aged 1-10 years undergoing elective circumcision under general anesthesia. The main questions this study aims to answer are: Are the actual preoperative fasting durations in children longer than the recommended fasting durations? Are prolonged fasting durations associated with increased preoperative anxiety levels in children? Is there a relationship between fasting durations and parental anxiety levels? Are prolonged fasting durations associated with preoperative blood glucose levels in children? Do parental educational levels influence adherence to preoperative fasting recommendations? The study will include children aged 1-10 years who are scheduled to undergo elective circumcision under general anesthesia at Yahyali State Hospital, Kayseri, Türkiye. Parents will be asked to report the last time their children consumed solid foods and clear liquids, and actual fasting durations will be calculated. Before surgery, children's anxiety levels will be assessed using the Modified Yale Preoperative Anxiety Scale (m-YPAS), while parental anxiety levels will be evaluated using the State-Trait Anxiety Inventory-State (STAI-State). Preoperative blood glucose levels will also be measured. No experimental treatments or interventions will be performed, and participation in the study will not result in any changes to routine anesthesia, surgical procedures, or perioperative care.

Impact of Different Fasting Strategies on Gastric Ultrasound and Anxiety Levels in Children

Children who undergo surgery are usually asked to stop eating and drinking for several hours before anesthesia to reduce the risk of stomach contents entering the lungs. However, long fasting times may cause discomfort, dehydration, low blood sugar, and increased anxiety in children. Recent guidelines suggest that clear liquids can safely be allowed closer to the time of surgery, and some enhanced recovery protocols even recommend giving carbohydrate-containing drinks before anesthesia. This study will compare three different preoperative fasting approaches in children undergoing elective inguinoscrotal surgery: traditional fasting, preoperative carbohydrate drinks, and the "Sip-Til-Send" approach, which allows clear fluids until the child is called to the operating room. The children's anxiety levels will be evaluated before surgery using a validated anxiety scale and assess stomach content and volume using gastric ultrasound. including gastric ultrasound findings (antral cross-sectional area, estimated gastric residual volume, and gastric fullness grade), gastric pH, blood glucose levels, and time to discharge readiness assessed using Ped-PADSS, will be evaluated. Additional clinical outcomes, including postoperative nausea, vomiting, pain, and delirium, time to first oral intake, and lengths of stay in the post-anesthesia care unit and hospital, will also be evaluated. The results may help determine safer and more comfortable fasting strategies for children undergoing surgery.

Gastric Emptying After a Yoghurt Breakfast in Children: a Pilot Study

Children are asked to fast before anaesthesia to reduce the amount of material remaining in the stomach. Prolonged fasting can cause hunger, thirst and discomfort. Although shorter fasting intervals have been introduced for clear fluids and breast milk, less is known about how quickly a light yoghurt breakfast leaves the stomach. Yoghurt differs from clear fluids in its nutrient content and semi-solid consistency. The primary aim of this study is to compare gastric emptying after three versus four hours of fasting following yoghurt intake in 24 children aged 1 to 10 years undergoing elective upper gastrointestinal endoscopy under anaesthesia at Baskent University Faculty of Medicine Ankara Hospital. Children will be randomly allocated to two equal groups. They may eat yoghurt freely up to a maximum of 150 g; there is no prescribed fixed or weight-based dose, and the amount actually eaten will be recorded. Ultrasound will assess stomach contents at the assigned fasting interval. If the stomach has not emptied according to the study criterion, the assessment will be repeated at 10-minute intervals before proceeding with anaesthesia. Gastric contents will also be assessed directly during endoscopy. The clinicians performing ultrasound and endoscopy will not know the assigned group; the anaesthetist will know it. The primary outcome is the proportion of children with an empty stomach at the first ultrasound assessment, compared between the three-hour and four-hour groups. The primary hypothesis is that a three-hour interval after yoghurt intake will yield a similar proportion of empty stomachs to a four-hour interval. Secondary outcomes include estimated gastric volume, endoscopic findings, hunger, and agreement between ultrasound and endoscopic assessment.

Change of Gastric Fluid Volume After Oral Hydration in Fasted Objects

This study aims to evaluate the permissive amount and time limit of clear fluid intake for preoperative fasting.

Preoperative Fasting Duration and Gastric Residue in Pediatric Upper Gastrointestinal Endoscopy

This retrospective observational study aims to evaluate the relationship between preoperative fasting duration and gastric residue in pediatric patients undergoing upper gastrointestinal endoscopy for gastrointestinal symptoms or pathology. The study will assess the associations between gastric residue, gastrointestinal symptoms, underlying gastrointestinal diseases, and endoscopic findings. Data will be retrospectively collected from hospital records, anesthesia records, and endoscopy reports to investigate whether prolonged fasting duration reliably predicts an empty stomach in pediatric gastrointestinal patients.

Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures

This single-center quality improvement project evaluates preoperative fasting times before elective procedures requiring anesthesiology care. The project aims to reduce prolonged fasting for clear fluids by implementing a local standard operating procedure (SOP) allowing patients to drink clear liquids until being called to the operating room ("drink until called"), supported by staff education and fasting instruction cards. Fasting times and selected perioperative outcomes will be assessed before and after implementation.

Baseline Gastric Volume in Diabetic vs Non-Diabetic Patients

During the preoperative preparation process, the fasting period for anesthesia is planned according to guidelines. According to standard guidelines, a fasting period of at least 2 hours is recommended for clear liquids, at least 6 hours for light meals, and at least 8 hours for a full meal. However, it has been reported that these guidelines are valid for healthy patients. It is thought that the planned fasting periods may vary in diabetic patients due to delayed gastric emptying. This study aims to calculate gastric volume under ultrasonography guidance and compare it with fasting time.

Effect of Preoperative Oral Carbohydrate Drink on ObsQoR-10 Score After Elective Cesarean Under Neuraxial Anesthesia

The goal of this clinical trial is to determine whether a preoperative oral carbohydrate-rich clear drink can improve recovery in women undergoing elective cesarean section under neuraxial anesthesia. The main outcomes it aims to answer are: Primary Outcome: Does the carbohydrate drink improve ObsQoR-10 scores at 24 and 48 hours postoperatively? Secondary Outcomes: Does it reduce patients' hunger, thirst, and anxiety levels? Researchers will compare patients receiving a 400 ml oral carbohydrate-rich clear drink 2 hours before surgery (Group A) to those receiving 400 ml distilled water (Group B), to assess differences in recovery and comfort. Participants will: Be randomized into two equal groups (n=50 each) using a computer-generated randomization table Receive standardized anesthesia and postoperative analgesia