Clinical Research Directory

Effect of a Standardized Moisture-Care Protocol Using Skin Barrier Spray on Prevention of Pressure Injuries in the Perineal-Sacral Area Among Incontinent Inpatients: A 3-month Pilot Study.

This pilot study aims to evaluate whether a standardized proactive moisture-care protocol using a silicone-based skin barrier spray can reduce early-stage pressure injuries (PIs) in the perineal-sacral area among incontinent inpatients. Incontinence leads to prolonged exposure of skin to moisture and irritants, resulting in Incontinence-Associated Dermatitis (IAD) and increased vulnerability to PIs. Currently, barrier products are applied reactively after skin redness appears. The proposed intervention introduces a proactive approach-daily application of barrier spray during routine morning care before visible damage occurs. Forty inpatients aged65 or above will be recruited from an acute medical ward over 12weeks. Participants admitted in weeks1-6 will receive usual care (control), and those in weeks7-12 will receive the proactive protocol (intervention). Each will be observed for up to14days or until discharge or skin breakdown. The primary outcome is the incidence of new Stage1-2PIs in the perineal-sacral area; secondary outcomes include IAD incidence, nursing compliance, workload, and cost comparisons. This minimal-risk study uses only approved hospital products, follows standard hygiene and safety procedures, and emphasizes proactive prevention to enhance patient outcomes, nursing efficiency, and resource sustainability. Results will guide future large-scale implementation of standardized moisture-care practices.

Evaluation of Commercially Available Heel Pads for the Prevention of Pressure Ulcers: An Observational Study of Incidence and Usability in Adult Surgical Patients.

This study will evaluate the incidence of heel pressure ulcers in adult patients undergoing elective surgery while using the Oasis Elite Heel Pad (EL130) as part of routine pressure ulcer prevention. The study will also explore the usability, acceptability, and perceived value of the heel pad among multidisciplinary surgical theatre staff. The study has two phases. Phase 1 is a prospective observational study involving approximately 35 adult surgical patients. The use of the heel pad is part of standard care and participation in the study will not alter participants' routine clinical care. Pressure ulcer development at both heels will be assessed using visual skin assessment (VSA) and subepidermal moisture (SEM) assessment with the Provizio® SEM Scanner. Assessments will be performed before surgery, hourly during surgery, and during postoperative follow-up for up to 72 hours. The primary outcome of Phase 1 is the incidence of heel pressure ulcers detected by SEM assessment and VSA. The study will also examine changes in SEM measurements during surgery and the time to development of a heel pressure ulcer during the study follow-up period. Phase 2 is a qualitative usability study involving approximately 15 multidisciplinary surgical theatre staff who have used the heel pads during the Phase 1 study period. Participants will take part in individual semi-structured interviews exploring the usability, acceptability, and perceived value of the heel pads for intraoperative pressure ulcer prevention.

Effect of a Risk-Based Perioperative Pressure Injury Prevention Bundle in Elective Surgery Patients

This study evaluates whether a risk-based perioperative pressure injury prevention bundle reduces the development of pressure injuries in patients undergoing elective surgery lasting 3 hours or longer. Pressure injuries that develop during and after surgery are a common patient safety problem, especially in older adults and in longer procedures. In this randomized controlled trial, patients will be assigned by chance to either an intervention group or a control group. In the intervention group, each patient's pressure injury risk will be assessed before surgery using the Braden Scale together with additional perioperative risk factors, and patients will then receive one of three prevention bundles matched to their risk level (low, moderate, or high). The high-risk bundle includes prophylactic silicone foam dressings on the sacrum and heels, targeted positioning, and pressure-redistributing support surfaces. The control group will receive standard perioperative care without risk-based bundling, although Braden Scale assessment will still be performed. Skin assessments will be conducted at four time points: before surgery, in the post-anesthesia care unit, at 2-4 hours after surgery, and at 24 hours after surgery. The main outcome is whether patients develop early signs of pressure injury, including non-blanchable erythema, within the first 24 postoperative hours. The study hypothesizes that patients receiving the risk-based prevention bundle will have a lower incidence of postoperative pressure injury and non-blanchable erythema compared with patients receiving standard care.

AI-Supported E-Learning for Pressure Injury Prevention

Brief Summary Pressure injuries are damage to the skin and underlying tissue that may occur in patients who stay in bed for long periods, have limited mobility or use medical devices. These injuries are often preventable. They may cause pain, infection, longer hospital stays and increased care costs. For this reason, it is important that nurses and nursing students have accurate knowledge, confidence and positive attitudes about preventing pressure injuries. The aim of this study is to compare two different methods of teaching pressure injury prevention to nursing students. One group of students received the education in a face-to-face classroom session. The other group completed the same topic through an artificial intelligence-supported modular e-learning programme. The e-learning programme included short videos, clinical examples, question-and-answer activities, short quizzes and feedback. The educational materials prepared with artificial intelligence support were checked by experts before being used with students. Undergraduate nursing students took part in the study. The students were randomly assigned to one of two groups. In both groups, measurements were taken before the education, immediately after the education and four weeks later. The study assessed students' knowledge of pressure injury prevention, their confidence in managing pressure injury prevention and their attitudes towards prevention. This study does not provide a treatment or direct intervention to patients. However, its findings may help improve how nursing students and future healthcare professionals are educated about pressure injury prevention. In the long term, better education may support safer patient care, help prevent pressure injuries and improve the quality of care.

The Effect of Silicone Foam Dressing and Repositioning on the Prevention of Endotracheal Tube-related Pressure Injuries

The endotracheal tube is one of the medical devices most associated with pressure injuries related to medical devices. This study aims to evaluate the effectiveness of applying a silicone foam dressing over the endotracheal tube and repositioning the endotracheal tube in preventing endotracheal tube-related pressure injuries in patients receiving mechanical ventilation support.

Biatain Silicone Sacral for Pressure Injury Prevention in Hospital-admitted Patients at Risk

A post market clinical follow-up study investigating the safety of Biatain Silicone Sacral while used as prevention in hospital admitted patients at risk of developing a pressure injury.

The Effect of a Color-Coded System on Pressure Injury Prevention in the Intensive Care Unit

This study is designed as a randomized controlled trial to examine the effect of using a color-coded classification system that identifies the risks of pressure injuries in the intensive care unit on the development of pressure injuries.

A Trial to Investigate the New Caulis Pro® Low Air Loss (LAL) System

Investigation of biomechanical and physiological functions of laying on a new mattress in healthy volunteers.

The Effect of Artificial Intelligence-assisted Visual Case Analysis on Nursing Students' Knowledge and Attitudes Towards Pressure Injury Prevention: A Single-blind Randomized Controlled Trial

The goal of this clinical trial is to examine the effect of artificial intelligence-assisted visual case analysis on nursing students' knowledge and attitudes towards pressure injury prevention. The main hypotheses it aims to answer are: * AI-assisted visual case analysis affects nursing students' knowledge about pressure injury prevention. * AI-assisted visual case analysis affects nursing students' attitudes toward pressure injury prevention. Researchers will compare AI-assisted case analysis to conventional case analysis to see if it affected nursing students' knowledge and attitudes about pressure injury prevention. Participants, * The case group will shown an AI-supported presentation explaining the pressure injury prevention case. The control group will given a classic case analysis. * At the end of the case, the PUPKAI and APuP scales will administered to the students in written form in the classroom.

The Effect of Web-Based Training and Counseling Given to Caregivers on the Pressure Injury Risk, Level of Dependence-Independence, and Caregivers' Burden of Care in Bedridden Patients

Education and counseling of patients and caregivers, either face-to-face or using various communication technologies, are reported to have significant effects. Nurses are in a key position in the education and counseling of patients and their relatives for the prevention of pressure injury. Although the share of health technologies in the management of pressure injury is important, it is also important for nurses to use these technologies. Web-based education, which is a part of health technologies, is defined as an education and training program created by using the features of internet and computer technologies.