Clinical Research Directory

Real World Evidence of SI-BONE's iFuse TORQ TNT Advancing Treatment of Pelvic Ring Fractures

The purpose of this study is to evaluate outcomes in patients treated with iFuse TORQ TNT for pelvic fragility fractures.

Effects of Pelvic Floor Exercises and Muscle Energy Techniques on Pain and Disability in Sacroiliac Joint Dysfunction

This clinical trial aims to evaluate whether combining pelvic floor exercises with muscle energy techniques provides greater improvement in pain and functional disability in adults with sacroiliac joint dysfunction compared to muscle energy techniques alone. The study examines whether the addition of pelvic floor training enhances pain reduction and functional outcomes beyond the effects of muscle energy techniques applied to the hamstrings, gluteus medius, piriformis, and iliopsoas muscles. Participants will be assigned to either an experimental group receiving both pelvic floor exercises and muscle energy techniques or a control group receiving muscle energy techniques only, and will complete standardized assessments of pain and disability before and after the intervention.

Comparison of High-Intensity and Conventional Physical Therapy in Musculoskeletal Disorders

This pilot randomized controlled trial aims to compare the clinical effectiveness of advanced high-intensity physical therapy modalities with conventional physical therapy in patients suffering from musculoskeletal disorders. The study focuses on three anatomical areas: lower back, shoulder, and knee. Participants will be randomized into two arms and will undergo 5 therapeutic sessions.

Post-Market Clinical Study on a Modular SI Joint Fusion System

A prospective study on the use of the TransLoc 3D SI Joint Fusion System for patients with sacroiliac joint disruptions or degenerative sacroiliitis.

Plantar Fascia Thickness and Pedobarometric Parameters in Sacroiliac Joint Dysfunction

This study aims to compare plantar fascia thickness and pedobarometric parameters between individuals with sacroiliak joint dysfunction and healty individuals.A total of 52 adult volunteers aged 18 to 50 years were included in the study, with 26 pariticipants in the sacroiliac joint dysfunction group and 26 participants in the healty control group.Participants with sacroiliac joint dysfunction were identified based on clinical examination and sacroiliac joint pain provocation tests. Foot posture was evaluated using the Foot Posture Index-6 (FPI-6), and participants with neutral foot posture were included. Plantar fascia thickness of both feet was measured using ultrasound. Static foot pressure measurements were performed during standing with eyes open and closed, and dynamic foot pressure measurements were performed during walking using a pedobarometric system. The study compares plantar fascia thickness and pedobarometric parameters between the sacroiliak joint dysfunction and control groups. It also investigates the relationship between plantar fascia thickness and pedobarometric parameters.

Does Injection Target Matter in Sacroiliac Joint Dysfunction?

This retrospective comparative cohort study aims to compare the short-term clinical outcomes of ultrasound-guided sacroiliac joint (SIJ) injection, combined SIJ and multifidus injection, and multifidus injection alone in patients with sacroiliac joint dysfunction. Medical records of patients who underwent ultrasound-guided injection procedures were retrospectively reviewed and classified into three groups according to the documented injection target: SIJ injection alone, combined SIJ and multifidus injection, and multifidus injection alone. The primary outcome is the change in pain intensity during movement, assessed using the Visual Analog Scale (VAS) from baseline to 30 minutes after injection. Pain outcomes at one week and changes in functional measures, including the Roland-Morris Disability Questionnaire and Oswestry Disability Index, are evaluated as secondary outcomes. The study aims to determine whether short-term pain and functional outcomes differ according to the injection target.

Effects of Modified Clamshell Training Versus Sling System Training on Pain, Functional Disability, and SIJ Nutation Control in Postpartum Women With SIJ Dysfunction

Sacroiliac joint dysfunction (SIJD) is a common musculoskeletal condition that can occur during the postpartum period due to pregnancy-related biomechanical, hormonal, and lumbopelvic changes. It may cause pain around the sacroiliac region, impaired pelvic stability, and functional disability, which can affect daily activities and quality of life. This randomized controlled trial will evaluate the effectiveness of Modified Clamshell Training (MCT) compared with Sling System Training (SST) in postpartum women with SIJ dysfunction. The study will assess the effects of both interventions on pain, functional disability, and SIJ nutation control. A total of 36 postpartum women with SIJ dysfunction will be randomly allocated into two groups, with 18 participants receiving MCT and 18 receiving SST. Both groups will receive the same baseline treatment, and the interventions will be delivered for 6 weeks, 3 sessions per week. Outcomes will be assessed before and after the intervention to determine changes in pain, functional disability, and SIJ nutation control.

Effect of Post-Radiofrequency Corticosteroid Injection on the Incidence of Post-Neurotomy Neuritis

The purpose of this study is to compare the incidence of post-neurotomy neuritis (PNN) in adult patients undergoing radiofrequency neurotomy (RFN) for spine facet and sacroiliac joint pain, comparing those who receive a local corticosteroid injection after the procedure with those who do not. Participants are randomly assigned to receive either local anesthetic with dexamethasone or local anesthetic alone at the treatment sites. Pain scores, functional disability, and adverse events are evaluated before the procedure and at 4 weeks follow-up.

Effects of Core Stability and Pelvic Clock Exercises in Sacroiliac Joint Dysfunction

The study will be a randomized control trial and will be conducted in DHQ and Sadiq Hospital in Sargodha District. This study will be completed in time duration of 10 months after the approval of synopsis. Nonprobability convenience sampling technique will be used and 50 participants will be recruited in study after randomization. The subjects will be divided into two groups. Group A(Experimental) will receive core stability and pelvic clock exercises with baseline treatment while Group B(Control) will receive only core stability exercises after baseline treatment. The tools that will be used are Numeric Pain Rating Scale (NPRS), Oswestry Disability index (ODI) and WHOQOL-BREF. Treatment have duration of 8 weeks with 3 sessions per week and an hour per session is requires. After data collection, data will be analyzed by using SPSS version 26.

Image-Guided Intra-Articular Versus Periarticular Injection in Sacroiliac Joint Pain

Sacroiliac joint (SIJ) pain is a common cause of chronic low back pain that can arise from within the joint itself or from the surrounding ligaments and supporting soft tissues. Image-guided injections using corticosteroids and local anesthetics are widely used to treat SIJ pain when physical therapy or medications fail. However, it remains uncertain whether administering the injection directly inside the joint space (intra-articular) or into the surrounding posterior ligaments (periarticular) provides greater early pain relief and functional recovery. The primary purpose of this clinical trial is to compare the efficacy, safety, and functional outcomes of fluoroscopy-guided intra-articular versus periarticular injections in adult patients with chronic sacroiliac joint pain. Participants are randomly assigned in a 1:1 ratio to receive one of two fluoroscopy-guided procedures: * Intra-Articular Injection Group: Participants receive an injection of methylprednisolone acetate and bupivacaine delivered directly into the synovial space of the sacroiliac joint under fluoroscopic guidance, confirmed with radiographic contrast. * Periarticular Injection Group: Participants receive an injection of methylprednisolone acetate and bupivacaine deposited along the posterior sacroiliac ligament complex and outer capsule under fluoroscopic guidance. All participants are followed for 8 weeks after the procedure. Changes in pain intensity are tracked using the Numeric Rating Scale (NRS) at baseline, 2 weeks, 4 weeks, and 8 weeks. Physical function and daily activity impairment are measured using the Oswestry Disability Index (ODI) at baseline, 4 weeks, and 8 weeks. Patient global improvement, side effects, and rescue pain medication consumption will also be monitored throughout the study period.

Comparative Effects of Pelvic PNF and HVLA Thrust in Sacroiliac Joint Dysfunction

This study, titled "Comparative Effects of Pelvic PNF and HVLA Thrust on Pain, Mobility, and Flexibility in Sacroiliac Joint Dysfunction," is a single-blinded randomized clinical trial (RCT) designed to evaluate and compare the therapeutic efficacy of two widely used but never directly compared manual therapy interventions Pelvic Proprioceptive Neuromuscular Facilitation (PNF) and High-Velocity Low-Amplitude (HVLA) thrust manipulation in individuals diagnosed with sacroiliac joint dysfunction (SIJD), a musculoskeletal condition responsible for a substantial proportion of low back pain cases worldwide yet frequently under-recognized and inconsistently managed in clinical practice. The trial will enroll a total of 62 participants, aged between 18 and 40 years, recruited from the rehabilitation departments of two collaborating institutions in Karachi, Pakistan Creek General Hospital and Dr. Ziauddin Hospital with the sample size derived through G\*Power software at a 95% confidence interval and 80% statistical power, based on a reference study, and inflated by 20% to account for anticipated attrition. Eligible participants will be clinically diagnosed with SIJD by an orthopedic surgeon using a cluster of provocation and motion palpation tests, and must present with a baseline pain intensity greater than 4/10 cm on the Visual Analog Scale (VAS) persisting for more than four weeks, while individuals who are pregnant or postpartum, report pain exceeding 8/10 cm on VAS, have diagnosed disc herniation, spinal stenosis, piriformis syndrome, true leg length discrepancy, recent spinal or lower-limb surgery, recent spinal injections or SIJ manual therapy, or active infection, malignancy, or uncontrolled hypertension will be excluded. Following informed written consent, participants will be randomly allocated through a sealed-envelope simple randomization technique into two equal groups of 31: Group A receiving Pelvic PNF, involving diagonal pelvic patterns such as anterior depression and posterior elevation combined with Rhythmic Stabilization and Contract-Relax Stretch techniques, and Group B receiving HVLA thrust manipulation, a controlled high-velocity, low-amplitude manual force applied directly to the sacroiliac joint. Baseline assessments, including demographic data (age, gender, height, weight, BMI, dominant and affected side) and outcome measures, will be conducted by a blinded, trained physiotherapist-assessor to minimize observer bias, with the three primary outcomespain intensity (via VAS), lumbo-pelvic mobility (via the Modified-Modified Schober Test), and posterior-chain flexibility (via the Sit and Reach Test) evaluated at three time points: baseline, six weeks post-intervention, and a twelve-week follow-up to determine the sustainability of treatment effects. The overall trial duration is set at six months following synopsis approval, and data will be analyzed statistically to test the null hypothesis (that HVLA is superior to Pelvic PNF) against the alternative hypothesis (that Pelvic PNF is superior to HVLA). Ethically, the study will proceed only after formal institutional approval, with all participants providing voluntary informed consent after receiving a Patient Information Sheet and adequate time for consideration, ensuring compliance with standard human-subject research protections. By generating the first direct, objectively measured comparison between these two conservative, non-pharmacological interventions, this trial aims to fill a clearly identified gap in the physiotherapy literature and provide clinicians with evidence-based guidance for selecting the more effective treatment approach in managing sacroiliac joint dysfunction, thereby improving conservative care pathways and clinical decision-making in orthopedic and physiotherapy practice.

Strain Counter-Strain vs Maitland Mobilization for Sacroiliac Joint Pain

This randomized clinical trial compares two manual therapy techniques for treating sacroiliac joint dysfunction, a condition that causes lower back and buttock pain. The two techniques are strain counter-strain, an indirect positional release method, and Maitland mobilization grades II and III, a direct joint oscillation technique. Thirty-four participants aged 20 to 40 years with confirmed sacroiliac joint dysfunction will be randomly assigned to receive either strain counter-strain or Maitland mobilization three times per week for four weeks. Both groups will also receive a 10-minute moist hot pack before each treatment. Pain will be measured using the Numeric Pain Rating Scale and functional limitation using the Modified Oswestry Disability Index at baseline and after four weeks. The study aims to determine which technique is more effective for reducing pain and improving function in this patient population.

Mobilization Versus Myofascial Release in Sacroiliac Joint Dysfunction

Sacroiliac joint dysfunction (SIJD) is a musculoskeletal condition associated with low back and pelvic pain, functional limitations, impaired postural control, and reduced spinal mobility. Although manual therapy techniques are commonly used in the conservative management of SIJD, evidence directly comparing joint-focused and fascial-focused approaches remains limited. This assessor-blinded, parallel-group randomized controlled trial compared sacroiliac joint mobilization and posterior chain-focused myofascial release, each applied in addition to a standardized conventional physiotherapy program, in adults aged 18-65 years with SIJD. Participants were randomly allocated in a 1:1 ratio to the mobilization group or the myofascial release group. Both groups received three supervised treatment sessions per week for six weeks. The primary outcomes were postural control assessed using the Biodex Balance System and spinal posture, mobility, postural endurance, and total Spine Check performance assessed using the Spinal Mouse system. Secondary outcomes were resting, activity-related, and night pain assessed using the Visual Analog Scale and functional disability assessed using the Oswestry Disability Index. Assessments were performed at baseline and immediately after the six-week intervention.

iFuse TORQ for the Treatment of Sacroiliac Joint Dysfunction

iFuse TORQ for the Treatment of Sacroiliac Joint Dysfunction (STACI) is a prospective, multicenter, study of SIJ fusion using the iFuse TORQ implant system.

Effects of Stecco Fascial Manipulation Versus Muscle Energy Technique on Pain Pressure Threshold, Range of Motion and Disability Among Patients With Sacroiliac Joint Dysfunction

This study holds significant importance as it directly addresses the need for effective physiotherapy interventions in patients with sacroiliac joint dysfunction, a condition that contributes substantially to lower back pain and disability. By comparing the effects of Fascial Manipulation and Muscle Energy Technique on pain pressure threshold, disability, and range of motion, the study provides evidence-based guidance for clinicians in selecting the most appropriate treatment. The findings can help physiotherapists develop more targeted rehabilitation plans, improve patient outcomes, and reduce treatment time. Additionally, this research adds to the limited literature available on stecco fascial manipulation and muscle energy technique approaches for SI joint dysfunction and may encourage further studies to refine and expand conservative management strategies. Ultimately, the study benefits both healthcare professionals and patients by promoting more efficient, safe, and effective physiotherapy care.

Comparison of Core Stability and Hip Strengthening Protocols in Sacroiliac Joint Dysfunction

The aim of this research is to compare the effects of core stability exercises and hip strengthening exercises on pain, posture, balance, proprioception, and functional status in patients with sacroiliac joint dysfunction. A randomized controlled trial will be conducted at Benazir Bhutto Hospital. The sample size will be 22 participants. The subjects will be divided into two groups, 11 subjects in the core stability exercise group and 11 subjects in the hip strengthening exercise group. The study duration will be 6 months. The sampling technique applied will be non-probability purposive sampling. Only 25-55 years individuals with unilateral sacroiliac joint dysfunction for more than 3 months and NPRS score ≥5 will be included. Tools used in the study are Numeric Pain Rating Scale (NPRS), Oswestry Disability Index (ODI), Pelvic Inclinometer, Flexicurve Ruler, Gait and Balance App, and Joint Repositioning Error test. Data will be analyzed through SPSS version 25.

Sacroiliac (SI) Joint Transfixing and Fusion: Meaningful Long Term Outcomes With Nevro1

The goal of this observational study is to learn if Nevro1 Sacroiliac Transfixing and Fusion System can treat sacroiliac joint dysfunction in males or females over 21. The main questions it aims to answer is what percentage of patients have clinically important pain relief with no adverse events, and what proportion of patients have fusion of the sacroiliac joint at 1 year and 2 years.

Posterior-Inferior Intra-articular Cortical Piercing Titanium Implant for Sacroiliac Joint Fusion: Evaluation of Safety and Effectiveness Outcomes

The purpose of this study is to evaluate outcomes in patients treated with iFuse INTRA Ti for chronic SI joint pain.

Post-Market Clinical Study Using TRAQ™ for Minimally Invasive Posterior Sacroiliac Joint Fusion

The purpose of this study is to evaluate the real-world performance, safety and efficacy of the TRAQ System.

Combined Effects of Mulligan's Mobilization With Movement and Kinetic Control Training on Pain, Range of Motion, Gait and Functional Disability Among Patients With Sacroiliac Joint Dysfunction

Sacroiliac joint dysfunction (SIJD) is a frequent source of low back and pelvic pain and contributes significantly to movement restriction, altered gait patterns, and functional disability in adults. It is associated with impaired lumbopelvic motor control, weakness of key stabilizing muscles, and faulty load transfer across the pelvis. SIJD is prevalent in both physically active individuals and sedentary populations. In addition to its clinical impact, SIJD imposes a considerable socioeconomic burden due to reduced work productivity and long-term disability. Contemporary management of SIJD emphasises on pain reduction, restoration of movement, functional independence, and participation in daily activities. Manual therapy techniques such as Mulligan's Mobilization with Movement (MWM) are widely used to correct positional faults and restore pain-free movement, while kinetic control training targets deficits in motor control of the lumbopelvic stabilizing muscles. Although both approaches are individually supported in the literature, evidence regarding their combined effectiveness on pain, range of motion, gait parameters, and functional disability remains limited. Therefore, this study aims to compare the effects of combined Mulligan's Mobilization with Movement and kinetic control training versus kinetic control training alone in patients with sacroiliac joint dysfunction using validated outcome measures.

Comparative Effects of Autogenic Inhibition and Reciprocal Inhibition Technique on Pain, Functional Disability and Gait in Sacroiliac Joint Dysfuction.

Sacro-iliac joint act as the shock absorber of the body. It is responsible for transferring vertical load of the whole body to lower limb hence contributing to stability of pelvic girdle. However, SI joint dysfunction is one of the most common causes of low back pain among the patients suffering from non-radicular low back pain. There can be a mechanical source which is due to muscle insufficiency or instability or a non-mechanical source which is osteoarthritis, infection or any trauma. It is thought to affect females more commonly with prevalence of about 46.71% in females and with the prevalence of about 15 to 30% in general. This poses great threat to bio mechanics of the body which can significantly lead to disability that can affect mobility, daily activities and quality of life of the individual. According to a study the pain caused by SIJD caused activity limitation and participation restriction of about 25% of the individuals. Hence making it difficult for them to continue their jobs. increased pain leads to worsening of the ability to perform ADLs which ultimately effects the quality of life. Altered biomechanics also leads to alteration in spatio temporal gait parameters.This study aims to compare the effects of autogenic inhibition technique and reciprocal inhibition technique in addition with conventional therapy in reliving low back pain, improving functional disability and alteration in spatio-temporal gait parameters in patients with sacroiliac joint dysfunction. Patients with SIJD will be recruited and will be randomly divided into two groups 20 in each group. Group 1 will receive autogenic inhibition technique of iliopsas, hamstrings, erector spinae and piriformis muscles along with standard core stabilization exercises and group 2 will receive reciprocal inhibition technique on iliopsas, hamstrings, erector spinae and piriformis muscles along with standard core stabilization exercises. The treatment will be continued for 3 weeks with 4 sessions of 25 minutes per week.

Gong's Mobilization and Jone's Positional Release for SIJ Dysfunction

This study aims to compare the efficacy of Gong's mobilization and Jones's positional release technique in individuals with sacroiliac joint dysfunction.

Kinetic Control Exercises to Reduce Pain and Improve Balance, Walking, and Stamina in Sacroiliac Joint Issues

The goal of this clinical trial is to evaluate the effectiveness of the Kinetic control on pain, endurance, Gait and postural stability in patients suffering from chronic sacroiliac joint dysfunction. The main question it aims to answer is: * Does kinetic control training work on pain in SIJ dysfunction? * Does kinetic control therapy work on functional outcomes, including gait metrics, postural sway, and lumbar endurance? The treatment arm will receive the Kinetic control training, and the comparison arm will undergo standard physical therapy care. Participants will be asked to perform movement control exercises based on the principle of kinetic control training core muscles and hip muscles after routine physical therapy. The participants in the control/comparison group will only receive routine physical therapy that includes a heating pad, TENS, joint mobilizations, and stretching and strengthening exercises.

Innovative Spinopelvic Solutions With Real-World Evidence

INSPIRE is a prospective decentralized study evaluating post-operative health outcomes in patients who undergo a procedure using implants manufactured by SI-BONE.