Clinical Research Directory

The Effects of Manual Acupuncture on Superoxide Dismutase Enzyme Activity and Questionnaire of Smoking Urges-Brief Scores in Active Smokers: A Randomized Controlled Trial

The goal of this randomized, double-blind clinical trial is to evaluate the effects of a single session of manual acupuncture on superoxide dismutase (SOD) enzyme activity and smoking cravings in active smokers aged 21-40 years. The study will also examine the correlation between changes in SOD enzyme activity and changes in smoking cravings, as measured by the Questionnaire of Smoking Urges-Brief (QSU-Brief). The main questions it aims to answer are: 1. Does a single session of manual acupuncture increase SOD enzyme activity, an indicator of antioxidant defense, 90 minutes after the intervention? 2. Does a single session of manual acupuncture reduce smoking cravings as measured by the Questionnaire of Smoking Urges-Brief (QSU-Brief)? 3. Is there a correlation between changes in SOD enzyme activity and changes in QSU-Brief scores? Researchers will compare a manual acupuncture group with a sham acupuncture group to determine whether manual acupuncture produces greater changes in SOD enzyme activity and smoking cravings. Participants will: 1. Be randomly assigned to receive either one 30-minute session of manual acupuncture or sham acupuncture. 2. Refrain from smoking for two hours before the intervention until the final blood sample is collected. 3. Undergo venous blood sampling before the intervention and 90 minutes after the intervention to measure SOD enzyme activity. 4. Complete the QSU-Brief questionnaire before and immediately after the intervention to assess changes in smoking cravings.

The Relationship Between Total Sialic Acid and Superoxide Dismutase and the Diagnosis and Prognosis of Lipoid Pneumonia

The goal of this observational study is to explore the correlation between total sialic acid combined with superoxide dismutase and the diagnosis and prognosis of lipid pneumonia in the patient with lipid pneumonia, cough, bacterial and fungal pneumonia, cryptogenic organizing pneumonia, pulmonary alveolar proteinosis, lung mucinous adenocarcinoma and pulmonary edema. The main question it aims to answer is: Whether superoxide dismutase (SOD) and total sialic acid (TSA) could be used as diagnostic markers to distinguish lipid pneumonia from patient with cough, and bacterial and fungal pneumonia, cryptogenic organizing pneumonia, pulmonary alveolar proteinosis, lung mucinous adenocarcinoma and pulmonary edema, whether SOD and TSA be associated with the prognosis of patients with lipid pneumonia? Participants will answer online survey questions about their symptoms, changes in oxygen status, and changes in the most recent CT image of the lung for up to 10 years after treatment. We will count participants' baseline data including: gender, age, smoking history, comorbidities, lung function, imaging findings, hormone use or not, ICU treatment, death or not, the type of cause of lipid pneumonia, how it is diagnosed, and their baseline SOD and TSA.