Clinical Research Directory

Mobile-Based Microlearning for Improving ICU Nurses' Adherence to Ventilator-Associated Pneumonia Prevention Protocols

Ventilator-associated pneumonia (VAP) is one of the most common healthcare-associated infections among mechanically ventilated patients and is associated with increased morbidity, mortality, length of intensive care unit stay, and healthcare costs. Adherence of intensive care unit (ICU) nurses to evidence-based VAP prevention protocols is essential for reducing the incidence of VAP; however, maintaining consistent adherence remains challenging. This randomized controlled trial aims to evaluate the effectiveness of a mobile-based microlearning educational program in improving ICU nurses' adherence to VAP prevention protocols. Eligible ICU nurses will be randomly assigned to either an intervention group receiving a mobile-based microlearning program or a control group receiving routine educational resources. The microlearning program will deliver short, focused learning modules through mobile devices using multimedia content, interactive activities, reminders, and reinforcement strategies. The primary outcome is nurses' adherence to VAP prevention practices. Secondary outcomes include nurses' knowledge regarding VAP prevention and knowledge retention over time. Findings from this study may support the integration of mobile-based microlearning approaches into continuing nursing education programs to enhance evidence-based practice in critical care settings.

Inhaled Amikacin Versus Placebo in Patients With Ventilator-associated Tracheobronchitis

The primary objective of the AMIVAT trial is to assess whether a 5-day course of inhaled amikacin, compared to placebo, reduces the incidence of progression to ventilator-associated pneumonia (VAP) at day 28 in intensive care unit (ICU) patients with ventilator-associated tracheobronchitis (VAT). Transition from VAT to VAP will be defined as the occurrence of a first VAP episode due to the same pathogens than those responsible for VAT.

Oropharyngeal Care With Colostrum, Chlorohexidine and Sodium Bicarbonate in Preventing Ventilator-associated Pneumonia in Preterm Neonates

comparing the effect of oral care with colostrum, chlorohexidine and sodium bicarbonate in prevention of ventilator-associated pneumonia in preterm neonates.

Diagnostic and Prognostic Value of Reticulated Platelet Fraction in Ventilator-Associated Pneumonia (REPLAY-VAP)

Ventilator-associated pneumonia (VAP) is a serious infection that occurs in patients who have been on mechanical ventilation for more than 48 hours in the intensive care unit (ICU). Early and accurate diagnosis is critical to reduce complications and improve outcomes. This prospective observational study aims to evaluate the diagnostic and prognostic value of reticulated platelet fraction (RP%) in patients diagnosed with VAP. Blood samples will be taken as part of routine care, and RP% levels will be analyzed using a standard hematology analyzer. The study will investigate whether RP% can help identify VAP earlier and predict outcomes such as mortality and response to antibiotics.