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A Case-Control Study Revealing Intraocular Microenvironment Characteristics in Patients With Ocular Diseases Based on Multi-Omics Analysis
Sponsor: First Affiliated Hospital of Zhejiang University
Summary
This project systematically investigates the role of the intraocular microbiome in various ocular diseases, including age-related macular degeneration, diabetic retinopathy, and cataracts. By establishing a comprehensive biobank comprising aqueous humor, ocular surface, peripheral blood, and fecal samples, the study aims to: 1. Characterize the disease-specific composition, distribution, and abundance of the intraocular microbiome. 2. Identify the potential origins of intraocular microorganisms by analyzing correlations between the intraocular microecology and microbiomes at the aforementioned external sites. 3. Elucidate the regulatory mechanisms of the intraocular microbiome in disease pathogenesis utilizing multi-omics sequencing and analysis. Ultimately, this research provides novel insights into the pathological mechanisms of intraocular microecology, establishing a scientific foundation for future precision interventions and therapeutic target development.
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2026-10
Completion Date
2030-08
Last Updated
2026-10-27
Healthy Volunteers
No
Conditions
Interventions
Not applicable- observational study
Since this is an obeservational study, intenvention is not applicable. We only collect sample through natural surgical steps, without doing harm to the patients.