Clinical Research Directory

A Multilevel Intervention to Improve Adherence to Childhood Cancer Survivorship

More than 80% of childhood cancer survivors develop serious or life-threatening late effects after cancer therapy, but \<20% receive recommended survivorship care offered at cancer center survivorship clinics. In a shared care model, the investigators propose to investigate an innovative multi-level intervention consisting of: 1) patient survivorship education via telehealth with the cancer center, 2) ongoing patient-tailored education program within the electronic health record patient portal, 3) a structured interactive phone communication between the cancer center and the primary care clinic, and 4) an in-person visit with the primary care clinic for survivorship care with the goal of achieving high rates of adherence to recommended surveillance for late effects, as well as improving patient and physician knowledge and self-efficacy. If this scalable intervention demonstrates patient completion of recommended care comparable to cancer center survivorship clinics, this innovative study has the enormous potential to deliver recommended care to a larger proportion of childhood cancer survivors and reduce survivorship care disparities, while engaging p to integrate survivorship care as part of overall, lifelong health maintenance.

Effects of Immersive VR, Non-Immersive VR, and 3D-Printed Models on Anatomy Learning and Cognitive Load

Interactions with virtual content can enhance the creation and retention of knowledge. While some studies have found that learning methods involving the body-such as tactile manipulation-can lead to deeper understanding and higher achievement scores, other studies suggest that highly embodied tasks may limit the effectiveness of education by placing excessive cognitive or physical demands on learners. This study aims to compare the effects of different forms of visual representation and interaction (2D, digital 3D, physical 3D) on learning performance, presence, embodiment, and cognitive load among college students.

Developing and Validating Health Education Module for Prostate Cancer Prevention Behavior in Iraqi Male University Staff

Research Objectives To compare the effectiveness of the education modules on the knowledge, attitude, and practice of male university staffs towards prostate cancer prevention behaviors by comparing the pre- and post-test of Iraqi male university staffs' knowledge, attitude, and practice. Study population The research will proceed to be performed in the country of Iraq. Participants in the research will be male university staff members who are employed at Middle Technical University (MTU). This university contains 17 colleges and institutes, divided into five colleges and twelve institutes that are spread across four cities in Iraq. Inclusion criteria 1. Males at risk are 40 years of age and over. 2. The male who educational level primary school and above. 3. The male who gives informed consent and is willing to participate in the study. 4. Men who did not receive any health education program about prostate cancer. Exclusion criteria 1. The male staff outside middle technical university. 2. The male who has prostate cancer. 3. The male who is critically illness. 4. Withdrawal criteria include males who are unable or unwilling to comply with the study requirements, failure to attend the meeting schedules, and have substantial changes in health conditions, such as developing new medical conditions, having serious adverse events, or any other conditions that could impact the study results. Study Design The study will be a Cluster Randomized Controlled Trial (Cluster RCT) study design among male university staff with a pre-test and post-test to evaluate the effectiveness of the intervention modules that will be used for the study in this phase. A control group will be chosen that has similar characteristics and functioning as the intervention group. Sampling method The study will consist of selecting one college or institute out of 8 using a simple random sampling method, which will involve the classification of one college or institute for the intervention group and one for the control group. This will be done by utilizing a randomization process. The participants will be volunteers to participate in the study, and then the final selection of study participants will be determined by the specific inclusion criteria established for each group. The selection of participants will be contingent upon adherence to the predetermined sample size.

Doulas as Environmental Educators and Partners Study

The aims of this project are: Aim 1: Determine the extent to which an environmental health literacy educational intervention designed for doulas improves their environmental health literacy of endocrine disrupting chemicals (EDCs) in personal care products. Hypothesis 1a. Doulas who participate in an environmental health literacy course will have a higher environmental health literacy score based on quantitative questionnaire evaluation post-course compared to pre-course. Hypothesis 1b. Doulas who participate in the environmental health literacy course will have a higher environmental health literacy scores post-course compared to doulas who do not take the environmental health literacy course. Aim 2: Determine the extent to which pregnant people counseled by doulas with training in environmental health literacy have higher environmental health literacy scores and lower usage of personal care products containing EDCs following doula counseling. Hypothesis 2a. Compared to pregnant people not counseled by doulas on EDCs in personal care products, pregnant individuals counseled by doulas on these EDCs will have improved scores in environmental health literacy. Hypothesis 2b. Compared to pregnant people not counseled by doulas on EDCs in personal care products, pregnant individuals receiving counseling will use fewer personal care products associated with containing EDCs based on a validated questionnaire. Aim 3: Determine whether concentrations of EDC biomarkers decreased after the intervention for the intervention group. Hypothesis 3: Urinary phthalate metabolite concentrations will be lower post-course compared to pre-course for the intervention group.

Evaluating the Effects of Reproductive Health Training on Provider Behavior

The goal of this randomized, controlled, single blinded trial is to evaluate the medium to long-term effects of an Afrocentric sexual health curriculum on health professional students' knowledge, attitudes, and clinical skills in providing sexual health in Tanzania.

Physiotherapy and Rehabilitation Students' Incontinence Knowledge Level

The aim of the study is to examine the urinary incontinence knowledge level and attitudes towards treatment in Physiotherapy and Rehabilitation students. With this study, students' knowledge levels about urinary incontinence and treatment parameters will be determined, and it will be possible to show whether there is a difference between genders in terms of knowledge levels.

Effects of Testicular Self-Examination Training Methods on Students' Behaviors and Health Beliefs

The goal of this cluster randomized controlled trial is to evaluate and compare the effects of different testicular self-examination (TSE) training methods on university students' health beliefs and self-examination behaviors regarding testicular cancer (TC) and TSE. The main questions it aims to answer are: * Does receiving brochure-based education or brochure plus audio recordings of TC patient experiences improve students' health beliefs (perceived susceptibility, seriousness, benefits, self-efficacy, and reduced barriers)? * Which educational method is more effective in increasing the frequency and performance of testicular self-examination behaviors compared to a control group? Researchers will compare three groups: * Intervention Group 1: Receives an educational brochure on TC and TSE. * Intervention Group 2: Receives an educational brochure combined with audio recordings of testicular cancer survivor/patient experiences. * Control Group: Receives no specific educational intervention during the study period. Participants will: * Complete baseline questionnaires regarding demographic information, TC/TSE knowledge, health beliefs, and baseline examination practices. * Receive the assigned educational material/session according to their randomized cluster. * Complete follow-up evaluations at 3 months post-intervention to assess changes in health beliefs, knowledge, and TSE behaviors.

Addressing Pregnant Women's First Trimester Worries and Information Needs With mHealth Solutions

The first 12 weeks of pregnancy, known as the first trimester, can be one of the most worrying times for women. (Where this lay summary refers to women, it should be taken to include people who do not identify as women but who have the capacity to become pregnant). Many experience nausea, bleeding, or anxiety about whether the pregnancy is progressing normally. Despite this, most women do not see a midwife or doctor until around 10 weeks into the pregnancy. This leaves a gap where they may have important questions but little professional support. As a result, many turn to mobile phone applications or the internet to find answers - but the quality of information online is mixed, and it can be confusing or even unsafe. This research aims to understand what support women really need in early pregnancy, what concerns they have, and whether a mobile health application (mHealth app) could help fill this gap in current pregnancy care in a safe and personalised way. The study will also ask healthcare professionals and digital health experts what such an application should include, and how it can be made accessible, and easy to understand for all women - including those with different levels of health knowledge and digital skills. To carry out the research, we will use a combination of online surveys and interviews. Women who are currently pregnant or have had a baby in the last two years will be invited to take part, along with healthcare professionals such as midwives and doctors, and experts in digital health. The survey will ask about their experiences in early pregnancy, how they have used digital tools or apps, and whether they felt their questions were answered before their first NHS appointment. The interview stage will allow participants to talk in more depth about what support they wanted and what would have helped them most. All participants will receive information about support services because we realise that discussing unmet information needs or worries in early pregnancy may be upsetting for some women. The views collected will inform the design of a new mobile application to support women during early pregnancy. The application will use artificial intelligence (AI) to personalise information based on each woman's needs and background, and to explain things clearly and simply. The content and design of the application will be reviewed by doctors and digital health specialists to make sure it is safe, accurate, and easy to use. Public and patient involvement is central to this project. A diverse group of women and representatives from grassroots organisations will be invited to shape the questions we ask, review the design of the application, and help us make it inclusive for people from different backgrounds. This research will help us create a practical, trustworthy, and inclusive tool to support women during one of the most vulnerable times in pregnancy when women don't usually see a doctor. If successful, it could be used widely across the NHS to help reduce anxiety, improve understanding, and ensure women get the right support earlier in their pregnancy with the long-term aim of improving outcomes for women, babies, and families across the UK.

Evaluation of a Disability-Focused Sexual and Reproductive Health Curriculum for Health Students in Tanzania

This randomized controlled trial will evaluate the efficacy of a three-day sexual and reproductive health curriculum focused on persons with disabilities and tailored to the Tanzanian context. The intervention will be delivered to medical, nursing, and midwifery students at Muhimbili University of Health and Allied Sciences in Dar es Salaam, Tanzania. Participants will be randomized to either receive the curriculum during the initial intervention period or to a waitlist control group that will receive the curriculum approximately 12 months later. Participants will complete surveys at baseline and at 3-month follow-up to assess changes in knowledge, attitudes, skills, comfort, and advocacy related to sexual and reproductive health care for persons with disabilities. Participants in the intervention group will also complete an immediate post-intervention survey after the three-day curriculum.

Evaluating the Effects of Reproductive Health Training on Provider Behavior - Aim 3

This study will evaluate the real-world effectiveness of a four-day Afrocentric sexual and reproductive health curriculum for health professional students in Tanzania. Medical, nursing, and midwifery students from the State University of Zanzibar, Kilimanjaro Christian University, and the University of Dodoma will receive the curriculum. The curriculum covers sexual health across the lifespan, sexual dysfunctions, key populations, sexual violence, clinical skills training, ethics, policy writing, community resources, and cultural considerations. Student outcomes will be assessed using surveys at baseline, immediately after the curriculum, and at 3-month and 12-month follow-up to examine changes in sexual health knowledge, attitudes, and sexual history and counseling skills.

WomenFocused Education in CArdiac REhabilitation (WECARE) Pilot RCT

The goal of this pilot clinical trial is to learn if a women-focused education program can improve knowledge, health, and well-being in women with heart disease who are attending cardiac rehabilitation. It will also help researchers understand if this program can be delivered successfully in different rehabilitation programs. The main questions it aims to answer are: * Is it feasible to deliver this women-focused education program within routine cardiac rehabilitation programs? * Do women who receive this program show improvements in heart health knowledge, quality of life, and healthy behaviours? Researchers will compare women who receive the Cardiac College for Women program plus usual cardiac rehabilitation to those who receive usual cardiac rehabilitation alone to see if the program leads to better outcomes. Participants will: * Be randomly assigned to receive either the women-focused education program or usual care * Attend cardiac rehabilitation as part of their regular care * Complete questionnaires at the start and end of the program * (If in the intervention group) attend online education sessions and use supporting materials * (Optional) take part in a group discussion about their experience after completing the program

The Validity and Reliability of the Turkish Version of the BBAQ

The Barriers to Being Active Quiz (BBAQ) was originally developed in English to identify barriers to physical activity. This study aims to translate and cross-culturally adapt the BBAQ into Turkish (BBAQ-T) and evaluate its psychometric properties.

Healthcare Provider Human Papillomavirus Education and Professional Skills Intervention

Healthcare providers (HCP) serving the El Paso U.S.-Mexico Border Region will be recruited to compare educational and professional skills interventions focused on the human papillomavirus (HPV). Our hypothesis is that improving provider knowledge and communication strategies about HPV and its vaccine will reduce hesitancy and increase uptake and completion among the populations they serve.

Culturally Tailored HPV Psychoeducational Multimedia Intervention

Community members ages 18 - 45 years old from the El Paso, Texas, U.S.-Mexico Border Region will be recruited to compare psychoeducational multimedia interventions focused on the human papillomavirus (HPV). Our hypothesis is that adults who view culturally tailored multimedia stories encouraging HPV vaccination will report higher vaccine uptake rates.

Improving Health Awareness Using Social Network Interventions

The overarching hypothesis of our study is that social network interventions using artificial intelligence and social media can be used to increase population awareness about health issues. The overarching objective is to improve population awareness on multiple relevant health issues using social network interventions (SNI) and estimate the effect by conducting randomized control trials. Increase population awareness about organ donation in California, especially among minorities

Mobile Mental Health Stigma Reduction Intervention Among Black Adults

Major depressive and anxiety disorders are highly prevalent in the general population and are a leading cause of disability. Black adults have a high burden of depression and anxiety. This study aims to assess a self- administered video-based intervention to reduce mental illness stigma and medical mistrust among Black adults with moderate to severe depression or anxiety.

Improving Parent Sign-Up for a Children's Stroke Awareness Program

Many families do not sign up for a school-based stroke awareness program (FAST Heroes) that teaches children and parents to recognize stroke symptoms and act quickly. This study compared four different ways of encouraging parents to complete online registration for the program: a printed letter sent home, an email, an email combined with follow-up reminders from teachers, and an email combined with teacher reminders plus an automated chatbot. Thirty-seven schools that had not previously had any parents register were assigned to one of these four approaches, and the study measured how many parents in each group registered within eight weeks. The goal was to identify practical, low-cost communication strategies that schools and public health programs can use to increase parent engagement with health education initiatives.

PALS for Pap Smear Follow up

In this study, the researchers will utilize information gained from patient interviews about their knowledge of the cervical cancer screening and treatment process, and perceived barriers surrounding appropriate follow up, to create content for the intervention.

Arogya Sangama: 3 Way Partnership of People, Providers, and Panchayat for Health

This is a two-year pilot project in the Raichur and Chamarajanagar districts of Karnataka, India aiming to enhance the overall performance of primary health systems, including service utilization, quality, and responsive care, specifically within the recently developed facilities called the Health and Wellness Centres (HWCs). It will leverage rural local government structures known as Gram Panchayat Task Forces (GPTFs) created during the Covid-19 pandemic to strengthen the services delivered by HWCs. The aim is to build capacities and empower these GPTFs to function as a collaborative platform involving people, panchayats, and healthcare providers. This approach seeks to promote-community ownership, grassroots synergy, and social accountability to strengthen HWC service delivery in rural Karnataka (India).

PCORI-CER-1306-03385 Lung Cancer Screening Decision Aid Development and Testing

Objectives: This protocol addresses the first phase of a larger project funded by the Patient-Centered Outcomes Research Institute to help heavy smokers make informed decisions about lung cancer screening with low-dose computed tomography (CT). A separate IRB protocol will be submitted for the larger, comparative study. In this initial development phase, our prototype patient decision aid will be updated to reflect current guidelines about lung cancer screening. The updated aid will then be pilot-tested in a new sample of patients. In addition, several of the study measures will be refined and further developed in preparation for the larger study. The specific aims of the measures and decision aid development phase of this project are as follows: Update the aid to reflect current screening guidelines and refine the aid via cognitive testing with patients/smokers; and pilot test the updated aid for acceptability with patients/smokers. Modify our current measure of lung cancer knowledge, conduct cognitive testing of the new measure with patients/smokers, and evaluate the reliability of the new measure in a sample patients/smokers.

Adapting Enhanced Recovery Programs for Low Health Literacy Patients

Low health literacy patients are a vulnerable population at high-risk for surgical disparities including longer hospital stays, more complications, and more readmissions. This study will adapt enhanced recovery programs (ERPs) to low health literacy patients with a multilevel, health literacy-based implementation strategy (called VISACT - VISuAl aids, Coach providers in communication, and Train organizations in health literacy) to improve ERP fidelity and thereby outcomes. In the final aim of this project (Specific Aim 3), the VISACT intervention will be tested in a pilot trial. Findings from this study will lay the foundation for a multi-institutional stepped-wedge trial and establish key principles for adapting interventions to eliminate disparities.

The Effect of Healthy Environment Education on Primary School Students' Attitudes Towards Environment

It is important to explain environmental literacy to every age group and segment of society and to raise awareness. Environmental education provided to younger age groups in particular teaches children to live in harmony with nature and not to become disconnected from it. Educational interventions in younger age groups can lead to them growing up with an awareness that, when they reach adulthood, enables them to behave consciously towards both their own lives and their environment. This is, in a sense, an important investment in the future. For this reason, the aim is to investigate the effect of Environmental Education on the Environmental Attitudes of Primary School Students and to examine the impact of the environmental education program titled "I Love and Protect My Environment" on the environmental attitudes and awareness levels of third-grade primary school students. The study predicts that the experimental group students will achieve a significant increase in their environmental attitudes and awareness scores compared to the control group. Furthermore, this effect is expected to be sustainable in follow-up measurements. The research results are expected to emphasize the importance of environmental education at the elementary school level and contribute to its integration into educational curricula.The purpose of this study is to examine the effect of Healthy Environment Education on the environmental attitudes of elementary school students. This study was designed as a three-month follow-up randomized controlled experimental design with pre-test and post-test. The population of the study consists of third-grade students attending Atatürk Elementary School in the central district of Kütahya province. The sample size was calculated using the G\*Power 3.1 program based on a 95% confidence level (α = .05), 80% test power (1-β = .80), and a medium effect size (Cohen's d = 0.5). According to these parameters, at least 57 participants are required for each group. In this regard, taking into account participant loss, 5% of participants will be added to each group, and 60 participants will be included in each group to increase the reliability of the analyses. The Introductory Information Form, Primary School Environmental Attitude Scale, and Primary School Environmental Awareness Scale developed by the researchers will be used as data collection tools. Data will be collected in the form of pre-tests, post-tests, and one- and three-month follow-up measurements. Descriptive statistical methods such as percentage, mean, mode, median, etc. will be used in statistical analyses. Depending on whether the study data are normally distributed, the Shapiro-Wilk or Kolmogorov-Smirnov test will be used to examine the sample size. If the study data show a normal distribution, t-tests (between two groups) or one-way ANOVA (for more than one group) will be used for group comparisons. If the data do not show a normal distribution, the Mann-Whitney U test or Kruskal-Wallis test will be used. Pearson or Spearman correlation analysis will be performed to determine the relationship between demographic factors and environmental attitudes. When it is necessary to examine the relationships between environmental attitudes and demographic and other independent variables, analyses will be performed using multiple regression analysis. Within the scope of the research, a 6-week "I Protect My Environment" education program will be implemented for the experimental group, while no intervention will be made for the control group throughout the study. It is planned to implement the education program for the students in the control group after the completion of the study.

African Americans (AA) Communities Speak

African Americans are less likely to receive quality end-of-life (EoL) care. Addressing disparities in EoL care will need efforts to support a better understanding of African American patients' EoL cultural values and preferences for EoL communication and the impact of historical and ongoing care delivery inequities in healthcare settings. Our proposed "Caring for Older African Americans" training program is designed to empower clinicians to improve goal-concordant EoL care delivery by using community-developed storytelling videos to create empathy with experiences of racism in EoL care, guidelines for culturally concordant EoL care delivery, and an implicit bias recognition and management training to mitigate bias in goals of care communication.

Health Literacy and Obesogenic Behaviors

The prevalence of adolescent behaviors that can lead to obesity are alarming, and reduced life expectancy is the future of America's youth if behavioral changes are not implemented to improve health and reduce the obesity burden. Researchers have argued that health literacy is a precursor to health knowledge and is necessary for translating knowledge about healthy choices into behavior, with low health literacy being associated with reduced preventive health behaviors in adults. Given the lack of health literacy-specific interventions addressing adolescents' obesogenic behaviors, the purpose of this study is to examine the preliminary effectiveness of adding a health literacy module to an obesity prevention intervention that addresses adolescents' obesogenic behaviors.