Clinical Research Directory

Pain During Heat Treatment for Lower Extremity Varicose Veins: Radiofrequency vs. Microwave

This study compares two common heat-based procedures for treating varicose veins in the legs: radiofrequency ablation (RFA) and microwave ablation (MWA). Both treatments use heat to close off diseased veins, but they work differently-RFA heats through direct contact, while MWA uses microwave energy that spreads heat more widely. The main question is: Which procedure causes less pain during the surgery? Participants will be randomly assigned to receive either RFA or MWA. Since the surgery is done under local anesthesia (not general anesthesia), patients remain awake throughout. We will measure their pain at four key moments: When the needle is first inserted Right after injecting the numbing fluid (tumescent anesthesia) During the heat treatment itself At the end of the entire procedure We will also track how much numbing fluid is used, how long the procedure takes, and any side effects. Patients will be followed for 30 days after surgery to monitor recovery and satisfaction. The goal is to find out whether one method is more comfortable for patients, and to identify which factors (such as age, vein size, or anxiety level) affect pain during each procedure. This will help doctors choose the best approach for each patient and improve the overall treatment experience.

Effect of Oral Antiplatelet or Anticoagulant Drugs on Postoperative Bleeding Risk and Venous Closure Rate in Patients With Lower Extremity Varicose Veins After Radiofrequency Ablation

This observational study aims to assess the effect of oral antiplatelet or anticoagulant drugs on key postoperative outcomes in patients with lower extremity varicose veins who have undergone radiofrequency ablation. Its main objectives are to determine the impact of these medications on postoperative 30-day bleeding risk and postoperative 3-month venous closure rate in this patient population. Researchers will compare three groups-patients receiving oral antiplatelet drugs, those receiving oral anticoagulant drugs, and those not receiving either type of drug-to identify differences in the two key outcomes. Participants will complete baseline data collection (including medical history, medication use, and lower extremity venous assessment) before or shortly after radiofrequency ablation, undergo 30-day postoperative follow-up to evaluate bleeding events (such as minor bleeding or major bleeding requiring medical intervention), receive venous ultrasound at 3 months postoperatively to measure venous closure rate, and report any medication changes or adverse events during the follow-up period.