Clinical Research Directory

Safety and Analgesic Efficacy of the Biased μ-Opioid Receptor Agonist Tegileridine for Post-Operative Analgesia in Patients Undergoing Bariatric Surgery

This single-center, stratified randomized double-blind trial tests tegileridine, a new pain drug, for pain relief after weight-loss surgery. Researchers will compare tegileridine with standard opioid pain medicine. Eligible patients having bariatric surgery will be randomly assigned to one of the two treatment groups. Patients and study teams will not know which treatment each participant receives. Participants will be grouped based on whether they have obstructive sleep apnea (OSA). The primary measurement is postoperative recovery quality in the first 24 hours after surgery using the QoR-15 survey. The study will also track pain scores, rescue pain medication use, and drug side effects for 7 days after surgery. There is no guaranteed benefit for participants. Study pain medicines may cause side effects. Doctors will provide rescue treatment for uncontrolled pain.

Virtual Reality-Assisted Nursing Intervention During Intrauterine Device Insertion

This randomized controlled trial evaluated the effects of a virtual reality-supported nursing intervention based on Kolcaba's Comfort Theory on women's comfort, emotional state, pain and physiological parameters during intrauterine device insertion. Seventy women attending a family planning clinic were individually randomized by lottery to a virtual reality group, who received the intervention in addition to routine care, or to a control group, who received routine care only.

Accelerated Dual-Protocol rTMS for Refractory Trigeminal Neuralgia

Brief Summary The goal of this clinical trial is to learn if an accelerated, dual-protocol high-frequency repetitive transcranial magnetic stimulation (rTMS) intervention can treat and achieve long-term pain relief (analgesia) in patients with pharmacologically refractory primary Trigeminal Neuralgia (TN). The main questions it aims to answer are: * Can a combined 10 Hz and 20 Hz rTMS protocol significantly reduce average facial pain intensity (measured via the Visual Analog Scale) at 1 month post-treatment? * Will the induced analgesic effect maintain clinical durability at the 3-month long-term longitudinal checkpoint? * Can this non-invasive treatment significantly down-regulate secondary emotional distress (anxiety and depression) and improve the overall quality of life for chronic pain patients? Participants will: * Undergo a rigorous pre-screening process, including an outpatient clinical examination by an independent neurologist to confirm refractory TN, and a digital EEG to rule out epilepsy or other neurological counter-indications. * Complete an initial baseline assessment using five standardized clinical tests (VAS, BPI, HADS, QoLp, and PGIC) to document pain intensity, symptom distribution, anxiety, depression, and baseline quality of life. * Sign a formal Informed Consent form prior to starting any medical procedures. * Receive non-invasive brain stimulation using the Neurosoft Neuro-MS/D magnetic stimulator, targeted at the primary motor cortex (M1) contralateral (opposite) to the painful facial side. * Complete a 5-day compressed treatment course consisting of 10 total sessions delivered twice daily (a 28-minute 10 Hz protocol followed immediately by a 9-minute 20 Hz protocol per session) with a strict 45-50 minute rest interval between the two daily sessions, totaling 9,000 stimuli per day. * Attend follow-up appointments exactly 1 month and 3 months after completing the treatment course to repeat the same clinical survey battery under identical conditions to track the durability of the therapeutic effect.

Dexmedetomidine in Sonographic Guided Erector Spinae Plane Block

to investigate the postoperative analgesic effect of dexmedetomidine addition with different doses as an adjuvant to bupivacaine to Erector spinae plane block after renal surgeries.

Influence of Superficial Parasternal Intercostal Plane Block on Internal Thoracic Artery Caliber to Facilitate Surgical Harvesting in CABG

Influence of Superficial Parasternal Intercostal Plane Block (SPIPB) on Internal Thoracic Artery (ITA) Caliber and Surgical Harvesting Efficiency in Coronary Artery Bypass Grafting (CABG)

The Effect of Breast Milk, 10% and 20% Dextrose on Pain and Physiological Variables During Heel Puncture in Infants

Pain, defined by the International Association for the Study of Pain as a subjective, sensory, and emotional experience, differs from nociception, which is merely a neural activity. Premature newborns, whose inhibitory fibers are not yet mature due to anatomical and physiological development and who have insufficient endogenous opioid release, experience painful stimuli much more intensely. The inability of this age group to verbally express pain makes the diagnosis, assessment, and management of pain entirely dependent on healthcare professionals. Pain that is not effectively managed leads to stress and loss of comfort in the short term, while in the long term it can cause permanent neurodevelopmental problems and alter the individual's pain threshold later in life. Premature infants, especially those in Neonatal Intensive Care Units (NICUs), are exposed to invasive procedures that cause moderate to severe pain, such as heel prick tests, much more frequently than healthy term infants. In this context, pain management is a fundamental and essential nursing responsibility for the infant's neuroprotective developmental care. The literature shows that various non-pharmacological methods, such as oral sucrose, non-nutritive sucking (NNS), facilitated flexion, and wrapping, are used to alleviate pain during interventional procedures. Although more readily available in NICUs, studies on the effectiveness of oral glucose solutions are more limited compared to sucrose. This research, designed to address this gap in the existing literature, aims to investigate the effect of "oral breast milk, 20%, and 10% dextrose solution administered with supportive positioning methods" on pain reduction during heel prick blood sampling in premature newborns. The results of this research are expected to contribute to the development of a new, easily applicable, effective, and evidence-based nursing intervention strategy for NICUs.

Psilocybin in Cancer Pain Study

The overall objective of this study is to assess the feasibility, safety and preliminary efficacy of psilocybin-assisted therapy to alleviate opioid-refractory pain in patients with advanced-cancer. The name of the study intervention used in this research study is: Psilocybin (a tryptamine derivative)

Testing the Timing and Application of Virtual Reality Distraction During Knee Injections in a VA Pain Clinic

The goal of this clinical trial is to learn whether virtual reality (VR) can be added to routine knee injection appointments at a VA outpatient pain clinic without slowing down or disrupting clinic operations. The study will enroll 45 adult veterans who are scheduled for a knee injection at the Atlanta VA Arcadia pain clinic. The main questions it aims to answer are * Can a VR headset be set up and used during a knee injection with minimal time disruptions? * How many patients agree to take part, how many need to stop using the headset early, and how satisfied are patients and clinicians with the experience? Researchers will compare patients who wear a VR headset during their injection to patients who receive the usual injection without VR. This will show whether VR may change anxiety, time spent thinking about pain, satisfaction, and memory of the procedure. Participants will: * Be assigned by chance to one of two groups. Two out of every three participants will use VR, and one out of every three will receive usual care only. * If in the VR group, wear a headset showing a virtual environment with little motion. A research team member will place the headset before the needle goes in and remove it after the injection is finished. * Receive their scheduled knee injection as usual from their clinician. * Complete a short survey right after the procedure. Taking part happens during one clinic visit and takes about 30 minutes. The knee injection itself is standard care and is not changed by the study.

PEACE: Comparing Chronic Pain Treatment Options

The purpose of this study is to compare two types of acupuncture with usual care on treating chronic pain. This study has three groups. Two groups will received acupuncture. One group will receive usual standard of care for 12 weeks and then will receive acupuncture. Acupuncture is an ancient Chinese technique of using very thin needles inserted in the skin to treat different symptoms and illness, and to promote healing. Each group will undergo a different method of needle administration.

Comparative Study of Regional Nerve Blocks in Primary Cleft Palate Repair

This study will evaluate whether adding a suprazygomatic maxillary nerve block to the standard palatal nerve block improves pain control after cleft palate repair surgery in children. Participants will be randomly assigned to receive either the standard palatal block alone or the standard palatal block combined with a suprazygomatic maxillary nerve block. Both techniques use medications commonly used for pain management during surgery. The purpose of this study is to determine whether the addition of the suprazygomatic maxillary nerve block reduces postoperative pain, decreases the need for opioid medications, and improves recovery after cleft palate repair. Researchers will compare pain scores, medication use, recovery outcomes, and any treatment-related complications between the two groups. Information collected from this study may help identify the most effective regional anesthesia approach for children undergoing cleft palate repair and may improve postoperative pain management and patient recovery.

Dexmedetomidine for Refractory Pain in Palliative Cancer Patients

The goal of this study is to find out whether the medication dexmedetomidine can be a safe and effective additional treatment for cancer patients whose pain is not well controlled by standard pain medicines (such as opioids). The study includes 30 palliative care patients who still have significant pain despite standard pain treatment. All participants will receive dexmedetomidine, and outcomes related to efficacy and safety will be systematically observed.

Analgesic Efficacy and Safety of Topical VMD-3866 Gel in Management of Pain Induced by Chemotherapy (CIPN)

Peripheral neuropathy is a disorder caused by damage to the peripheral nerves. Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of certain chemotherapy drugs, such as platinum-based compounds, taxanes, and vinca alkaloids, which can damage nerve fibres by disrupting their structure and function. At present, relief of neuropathic pain in CIPN is limited, and existing therapies providing only modest and variable efficacy across patients. This is a study of VMD-3866 gel (the study medicine which is non-opioid, non-NSAID), an experimental new topical medicine for treating pain caused by CIPN. The goal of this study is to assess if the study medicine improves pain symptoms in patients with CIPN, and to find out the side effects of the study medicine if any. The study medicine will work by selectively blocking a specific sub-type of proteins (called T-type calcium channels) in the nerves under the skin which will lower the activity of the nerves and therefore reduce pain. It is a topical gel, meaning that it is applied to the skin, and its novel gel formulation limits that only little amount of study medicine may enter the blood and none enters the brain. This means it's unlikely to be addictive and it's unlikely to have any impact on participant current medications. Researchers will compare study medicine to a matching placebo (a look-alike gel that contains no drug) to see if VMD-3866 gel works to management of pain caused by CIPN.

Effects of Adding Motor Imagery Training to Exercise on Pain, Fibromyalgia Impact, and Kinesiophobia in Women With Fibromyalgia: a Randomized Controlled Trial

Aim: To evaluate the effects of adding motor imagery training to exercise on pain, fibromyalgia impact, and kinesiophobia in women with fibromyalgia, and compare imagery ability and kinesiophobia with healthy volunteers. Methods: In this randomized controlled study, 100 women with fibromyalgia were allocated to exercise alone (n=50) or exercise plus motor imagery training (n=50) for one month. Forty-five healthy volunteers provided baseline comparisons. Outcomes included Visual Analog Scale (VAS) pain and global assessment, Revised Fibromyalgia Impact Questionnaire (FIQR), and Tampa Scale of Kinesiophobia (TSK). Baseline imagery ability was assessed using the Kinesthetic and Visual Imagery Questionnaire-20.

Comparison of Two Postoperative Care Strategies After Breast Surgery

The goal of this clinical trial is to compare two postoperative analgesia strategies in adult women undergoing breast surgery and to evaluate their effects on postoperative pain and quality of recovery after hospital discharge. The main questions it aims to answer are: * Does a patient education-based analgesia strategy improve postoperative pain control compared with standard analgesic management? * Does the patient education-based strategy improve quality of recovery after hospital discharge? Researchers will compare the patient education group with the standard care group to assess differences in postoperative pain intensity and quality of recovery. Participants will: * Receive either a patient education-based postoperative analgesia strategy or standard postoperative analgesic management. * Complete questionnaires assessing pain, quality of recovery, and other aspects of health at specified time points. * Be followed for 90 days after surgery.

Comparison of a Comfort Scale and a Numerical Pain Scale on Opioid Consumption After Surgery

The objective is to show that the use of therapeutic communication tools, in this case a comfort scale, a low cost and simple to implement method, can reduce pain and therefore the consumption of opioids in the postoperative care unit. Our hypothesis is that the use of a comfort scale will lead to significant postoperative opioid sparing, and consequently to a decrease in the opioid-related side effects The aim of this study is to compare postoperative opioid consumption between patients whose pain is assessed by a numerical verbal scale and those assessed with a comfort scale.

Neuroma-Associated Pain Management After Combat-Related Trauma in Ukraine

This multicenter interventional study in Ukraine is designed to compare the effectiveness of cryoablation and radiofrequency ablation in managing neuroma-associated pain following combat-related trauma. Adult patients with clinically significant neuropathic pain caused by neuromas will be randomly assigned to receive either image-guided cryoablation or radiofrequency ablation of the affected nerve. Cryoablation uses controlled cold temperatures to temporarily disrupt nerve conduction, while radiofrequency ablation uses thermal energy to modulate nerve function. Both interventions are minimally invasive and performed under image guidance. The study will evaluate changes in pain intensity, opioid consumption, functional outcomes, and patient-reported measures at predefined time points following the procedure. This research aims to provide evidence on which intervention is more effective in reducing pain, improving function, and minimizing the need for opioid medications in patients with combat-related neuroma pain.

Does Injection Target Matter in Sacroiliac Joint Dysfunction?

This retrospective comparative cohort study aims to compare the short-term clinical outcomes of ultrasound-guided sacroiliac joint (SIJ) injection, combined SIJ and multifidus injection, and multifidus injection alone in patients with sacroiliac joint dysfunction. Medical records of patients who underwent ultrasound-guided injection procedures were retrospectively reviewed and classified into three groups according to the documented injection target: SIJ injection alone, combined SIJ and multifidus injection, and multifidus injection alone. The primary outcome is the change in pain intensity during movement, assessed using the Visual Analog Scale (VAS) from baseline to 30 minutes after injection. Pain outcomes at one week and changes in functional measures, including the Roland-Morris Disability Questionnaire and Oswestry Disability Index, are evaluated as secondary outcomes. The study aims to determine whether short-term pain and functional outcomes differ according to the injection target.

Anterior Iliopsoas Space Block Versus PENG Block on Ease of Positioning for Spinal Anathesia in Patients Undergoing Hip Surgeries

Total hip arthroplasty (THA) has been one of the most significant advancements in orthopedic surgery over the past century. hip fractures are typically associated with severe pain, effective analgesia is crucial both before and after surgery.Spinal anesthesia (SA) is the most commonly employed method of anesthesia for repairing these fractures.The anterior iliopsoas space block is a considered as a novel technique that targets the lumbosacral trunk as it passes beneath the psoas major muscle, offering potential advantages over the traditional sacral plexus block, which is performed in the supine position.

Online Pain Management Programmes During the Covid-19 Pandemic

A focus groups study facilitating an open discussion regarding the experience of being assessed for an online Pain Management Programme (OPMP) during the Covid-19 Pandemic. The aim is to gain an understanding of patient decision making processes in relation to whether to attend an OPMP. and determining patient experiences of attending a OPMP during this time period.

Percutaneous Tenotomy Versus Radiofrequency Ablation for Rotator Cuff Tear - Related Pain.

Rotator cuff tears are among the most common direct and indirect causes of chronic shoulder pain. Patients with irreparable rotator cuff tears face a choice of pain management options. The principal treatments available for chronic shoulder pain associated with irreparable rotator cuff tears include arthroscopic tenotomy of the long head of the biceps tendon, shoulder arthroplasty, pharmacological treatment, and radiofrequency ablation of the suprascapular nerve. Arthroscopic tenotomy of the long head of the biceps tendon is an established treatment for pain associated with massive irreparable rotator cuff tears, as supported by the available literature. Radiofrequency ablation of the suprascapular nerve provides temporary pain control by destroying the sensory nerve fibres supplying the shoulder joint. Tenotomy of the long head of the biceps tendon can be performed safely using a minimally invasive, ultrasound-guided outpatient procedure under local anaesthesia, without the general anaesthesia required for arthroscopy. The aim of the study is to compare the reduction in pain intensity and the duration of analgesia following percutaneous tenotomy of the long head of the biceps tendon versus continuous radiofrequency ablation of the suprascapular nerve. Changes in shoulder mobility limitations following the two procedures will also be compared using the Constant-Murley score, which assesses shoulder function.

Hypnosis Antalgia Emergency Stitching

Pain is one of the most common reasons patients seek care in emergency departments. Managing pain effectively is an important part of emergency care because it can improve patients' comfort and overall experience. Wounds that require stitches are also a common reason for visiting the emergency department. Stitching a wound can be painful, both because of the original injury and because of the procedure itself, even when local anesthetic is used. Hypnosis is a state of focused attention in which people may become more responsive to suggestions. It is increasingly used as a non-drug approach to managing pain and anxiety, including during medical and surgical procedures. However, hypnosis is still not widely used in emergency departments, mainly because it usually requires trained staff and additional time. One possible solution is to use a pre-recorded hypnosis audio. Instead of a healthcare professional performing hypnosis directly, the patient could listen to a guided recording during the procedure. Previous research suggests that this approach may provide pain relief similar to that achieved with live hypnosis. HYPNAUS is a study comparing the use of local anesthesia via subcutaneous lidocaine injection with hypnotic guidance via headphones combined with local anesthesia via subcutaneous lidocaine injection alone. We hypothesize that patients receiving hypnotic guidance combined with local anesthesia via subcutaneous lidocaine injection will experience less pain during the stitching procedure.

BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI)

The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and sham BreEStim and Transcutaneous Electrical Nerve Stimulation (TENS) in management of neuropathic pain in patients after spinal cord injury (SCI).

Suzetrigine in TKA

Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery. Despite widespread use of multimodal regimens, many patients still rely on opioids, which can cause sedation, nausea, constipation, and long-term dependency. Evaluating suzetrigine in this high-need population may improve recovery trajectories, reduce opioid consumption, and support enhanced recovery protocols. Given the growing surgical volume and the emphasis on opioid-sparing strategies, rigorous investigation of suzetrigine's efficacy in total knee replacement is of high clinical value. In this confirmatory (phase III) trial, patients undergoing primary total knee replacement will be randomized to receive either suzetrigine or placebo for 2 weeks (14 days), with the loading dose administered prior to surgery. The primary outcome is cumulative 48-hour opioid consumption in oral morphine equivalents starting from entry into the post-anesthesia care unit (PACU).

Analgesic Efficacy of Ultrasound-Guided Deep Iliacus Plane Block in Patients Undergoing Hip Fracture Surgery

Hip fracture surgery is commonly associated with moderate to severe postoperative pain, which may delay mobilization and increase the need for opioid analgesics. The deep iliacus plane block is a recently described ultrasound-guided regional anesthesia technique designed to provide analgesia by allowing local anesthetic spread toward the femoral nerve, lateral femoral cutaneous nerve, and articular branches supplying the hip. This prospective, randomized, double-blind, sham-controlled clinical trial will evaluate the analgesic efficacy of the deep iliacus plane block in adult patients undergoing hip fracture surgery under spinal anesthesia. After surgery, participants will be randomly assigned to receive either an ultrasound-guided deep iliacus plane block with local anesthetic or a sham block with normal saline. All participants will receive standardized multimodal postoperative analgesia, including patient-controlled analgesia. The primary objective is to determine whether the deep iliacus plane block reduces postoperative opioid consumption during the first 24 hours after surgery. Postoperative pain scores, rescue analgesic requirements, sensory distribution, motor block, nausea and vomiting, quality of recovery, patient satisfaction, and block-related complications will also be evaluated.